Factors associated with degraded trabecular bone score in heart transplant recipients

Rakuša, Matej; Poglajen, Gregor; Vrtovec, Bojan; Goričar, Katja; Jensterle, Mojca

doi:10.1111/ctr.14274

Cited by 2 publications

(3 citation statements)

References 45 publications

(67 reference statements)

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“…Our prevalence of clinical VFs in HFrEF was close to that Lyons et al found in HF in Canada [17], with most of the VFs happening in osteoporotic patients although Rakusa and coworkers observed it in patients with osteopenia with impaired TBS [19]. However, neither of these studies associated TBS and BMD with fractures, maybe because of the lack of sample power or because the baseline TBS values were already low.…”

Section: Plos Onesupporting

confidence: 78%

“…In HF with reduced ejection fraction (HFrEF), 55% of heart transplant patients had impaired or partially impaired TBS, with reduction over time after transplantation. Low TBS was also associated with age, higher body mass index (BMI), and low BMD, and although most fractures in these patients occurred with osteopenia, no association between degraded TBS and the presence of vertebral fractures (VFs) has been described [19].…”

Section: Introductionmentioning

confidence: 97%

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Bone quality, mineral density, and fractures in heart failure

Canteri,

Gusmon,

Boguszewski

et al. 2023

PLoS ONE

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Background The trabecular bone score (TBS) indirectly estimates bone quality and predicts low-impact fractures independently of bone mineral density (BMD). However, there is still a paucity of data linking bone and heart diseases, mainly with gaps in the TBS analysis. Methods In this cross-sectional study, we evaluated TBS, BMD, and fractures in patients with heart failure with reduced ejection fraction (HFrEF) and in sex-, BMI- and age-matched controls, and we assessed the fracture probability using the FRAX tool, considering active search for fractures by vertebral fracture assessment (VFA) and the adjustment for the TBS. Results TBS values were 1.296 ± 0.14 in 85 patients (43.5% women; age 65 ± 13 years) and 1.320 ± 0.11 in 142 controls (P = 0.07), being reduced (< 1.31) in 51.8% and 46.1% of them, respectively (P = 0.12). TBS was lower in patients than in the controls when BMD was normal (P = 0.04) and when the BMI was 15–37 kg/m2 (P = 0.03). Age (odds ratio [OR] 1.05; P = 0.026), albumin (OR 0.12; P = 0.046), statin use (OR 0.27; P = 0.03), and energy intake (OR 1.03; P = 0.014) were associated with reduced TBS. Fractures on VFA occurred in 42.4% of the patients, and VFA and TBS adjustment increased the fracture risk by 16%-23%. Conclusion Patients with HFrEF had poor bone quality, with a better discriminating impact of the TBS assessment when BMD was normal, and BMI was suitable for densitometric analysis. Variables related to the prognosis, severity, and treatment of HFrEF were associated with reduced TBS. VFA and TBS adjustment increased fracture risk.

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Section: Plos Onesupporting

confidence: 78%

Section: Introductionmentioning

confidence: 97%

Bone quality, mineral density, and fractures in heart failure

Canteri,

Gusmon,

Boguszewski

et al. 2023

PLoS ONE

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“…2,3 Osteoporosis is one of the important causes of morbidity after lung transplantation, and fractures resulting from it can significantly affect the life expectancy of patients. Numerous studies have documented the degree of bone mass loss that occurs after kidney [4][5][6] , heart 7,8 , and liver [9][10][11] transplantation. Lung transplantation has been associated with a decrease in bone mass index, but there are few studies on this topic.…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density in Lung Transplant Recipients: Experience of A Referral Lung Transplantation Center

Güney

Irmak

Halis

et al. 2023

Turkish Journal of Internal Medicine

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Background Osteoporosis is a well-recognized and curable complication of lung transplantation. This study aimed to determine the degree of bone mineral density before transplantation and to evaluate the risk factors associated with osteoporosis in lung transplant patients. Material and Methods The bone mineral density of 72 patients who underwent lung transplantation with the diagnosis of end-stage lung diseases between December 2016 and April 2021 was evaluated in the pre-transplant period. Results 58 of 72 patients who underwent lung transplantation were included in the study. The age range of the cases was 14-64 (mean 48) years, and 14 (23.7%) were female. The presence of osteoporosis in the study population was 49.2% (n: 29), and osteopenia was 40.7% (n: 24). Osteoporosis was significantly more common in patients with younger age and lower body mass index (p = 0.024 and p = 0.009, respectively). And most down forced expiratory volüme 1 values were in patients with osteoporosis (p < 0.001 and p = 0.008, respectively). Steroid usage (OR: 0.06, 95% CI: 0.01-0.36, p = 0.002) in T score (femur neck) and 1.25 dihydroxy vitamin D (OR: 1.15, 95% CI: 1.03-1.28, p = 0.012) in T score (lumbal spine) were found to be independent predictors of osteoporosis according to multivariate analyzes. Conclusions A significant proportion of patients with end-stage lung disease undergoing lung transplantation have osteoporosis and osteopenia. Interestingly, the candidates were similarly affected despite the variety of underlying conditions. Since osteoporosis is treatable, strict follow-up and treatment management are recommended before referral for transplant candidates.

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Factors associated with degraded trabecular bone score in heart transplant recipients

Cited by 2 publications

References 45 publications

Bone quality, mineral density, and fractures in heart failure

Bone quality, mineral density, and fractures in heart failure

Bone Mineral Density in Lung Transplant Recipients: Experience of A Referral Lung Transplantation Center

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