Factors Associated With Depression in Patients With Tinnitus and Hyperacusis

Aazh, Hashir; Moore, Brian C. J.

doi:10.1044/2017_aja-17-0008

Cited by 43 publications

(39 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mechanisms underlying hyperacusis following mTBI are unknown, although proposed theories suggest a tonotopic reorganization and hyperexcitability of the auditory cortex involving a malfunction of 5-HT (61), a release of endogenous opioid peptides (62), and a decreased GABA A -mediated inhibition in the inferior colliculus (63). Many studies have shown that the sleep disturbance generated by hyperacusis is mediated by psychological factors (58,64,65). Anxiety and hyperresponsiveness to every sound while one is trying to sleep could result in insomnia.…”

Section: Discussionmentioning

confidence: 99%

Clinical Correlates of Insomnia in Patients with Persistent Post-Traumatic Headache Compared with Migraine

Kim

Chong

Dumkrieger

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients with persistent post-traumatic headache (PPTH). The study objective was to contrast the severity of insomnia symptoms in PPTH, migraine, and healthy controls, and to identify factors associated with insomnia in patients with PPTH vs. migraine. Methods In this cross-sectional cohort study, 57 individuals with PPTH attributed to mild traumatic brain injury, 39 with migraine, and 39 healthy controls were included. Participants completed a detailed headache characteristics questionnaire, the Migraine Disability Assessment Scale (MIDAS), Insomnia Severity Index (ISI), Hyperacusis Questionnaire (HQ), Allodynia Symptom Checklist, Photosensitivity Assessment Questionnaire, Beck Depression Inventory (BDI), State-Trait Anxiety Inventory, Post-Traumatic Stress Disorder (PTSD) checklist, Ray Auditory Verbal Learning Test, and the Trail Making Test A and B to assess headache characteristics, disability, insomnia symptoms, sensory hypersensitivities, and neuropsychological factors. Fisher’s test and one-way ANOVA or Tukey’s Honest Significant Difference were used to assess group differences of categorical and continuous data. Stepwise linear regression analyses were conducted to identify clinical variables associated with insomnia symptoms. Results Those with PPTH had significantly higher ISI scores (16.7 ± 6.6) compared to migraine patients (11.3 ± 6.4) and healthy controls (4.1 ± 4.8) ( p < 0.001). For those with PPTH, insomnia severity was most strongly correlated with the BDI (Spearman's rho ( Common.EditSubmissionSteps.Transform.EquationText ) = 0.634, p < 0.01), followed by Trait Anxiety ( Common.EditSubmissionSteps.Transform.EquationText = 0.522, p < 0.01), PTSD ( Common.EditSubmissionSteps.Transform.EquationText = 0.505, p < 0.01), HQ ( Common.EditSubmissionSteps.Transform.EquationText = 0.469, p < 0.01), State Anxiety ( Common.EditSubmissionSteps.Transform.EquationText = 0.437, p < 0.01), and MIDAS scores ( Common.EditSubmissionSteps.Transform.EquationText = 0.364, p < 0.01). According to linear regression models, BDI, headache intensity, and hyperacusis scores were significantly positively associated with insomnia severity in those with PPTH, while only delayed memory recall was negatively associated with insomnia severity in those with migraine. Conclusions Insomnia symptoms were more severe in those with PPTH compared to migraine and healthy control cohorts. Depression, headache intensity, and hyperacusis were associated with insomnia in individuals with PPTH. Future studies should determine the bidirectional impact of treating insomnia and its associated symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Correlates of Insomnia in Patients with Persistent Post-Traumatic Headache Compared with Migraine

Kim

Chong

Dumkrieger

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Mechanisms underlying hyperacusis following mTBI are unknown, although proposed theories suggest a tonotopic reorganization and hyperexcitability of the auditory cortex involving a malfunction of 5-HT [61], a release of endogenous opioid peptides [62], and a decreased GABA Amediated inhibition in the inferior colliculus [63]. Many studies have shown that the sleep disturbance generated by hyperacusis is mediated by psychological factors [58,64,65]. Anxiety and hyperresponsiveness to every sound while one is trying to sleep could result in insomnia.…”

Section: Discussionmentioning

confidence: 99%

Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine

et al. 2020

View full text Add to dashboard Cite

Background: Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients with persistent post-traumatic headache (PPTH). The study objective was to contrast the severity of insomnia symptoms in PPTH, migraine, and healthy controls, and to identify factors associated with insomnia in patients with PPTH vs. migraine. Methods: In this cross-sectional cohort study, 57 individuals with PPTH attributed to mild traumatic brain injury, 39 with migraine, and 39 healthy controls were included. Participants completed a detailed headache characteristics questionnaire, the Migraine Disability Assessment Scale (MIDAS), Insomnia Severity Index (ISI), Hyperacusis Questionnaire (HQ), Allodynia Symptom Checklist, Photosensitivity Assessment Questionnaire, Beck Depression Inventory (BDI), State-Trait Anxiety Inventory, Post-Traumatic Stress Disorder (PTSD) checklist, Ray Auditory Verbal Learning Test, and the Trail Making Test A and B to assess headache characteristics, disability, insomnia symptoms, sensory hypersensitivities, and neuropsychological factors. Fisher's test and one-way ANOVA or Tukey's Honest Significant Difference were used to assess group differences of categorical and continuous data. Stepwise linear regression analyses were conducted to identify clinical variables associated with insomnia symptoms. Results: Those with PPTH had significantly higher ISI scores (16.7 ± 6.6) compared to migraine patients (11.3 ± 6.4) and healthy controls (4.1 ± 4.8) (p < 0.001). For those with PPTH, insomnia severity was most strongly correlated with the BDI (Spearman's rho (ρ) = 0.634, p < 0.01), followed by Trait Anxiety (ρ = 0.522, p < 0.01), PTSD (ρ = 0.505, p < 0.01), HQ (ρ = 0.469, p < 0.01), State Anxiety (ρ = 0.437, p < 0.01), and MIDAS scores (ρ = 0.364, p < 0.01). According to linear regression models, BDI, headache intensity, and hyperacusis scores were significantly positively associated with insomnia severity in those with PPTH, while only delayed memory recall was negatively associated with insomnia severity in those with migraine.

show abstract

“…The relationship between the severity of tinnitus and sleep disturbances has been highlighted by several authors (Tyler and Baker, 1983;Meikle et al, 1984;Folmer and Griest, 2000;Schecklmann et al, 2015;Cronlein et al, 2016). Recent studies suggest that more than 70% of patients seeking help for tinnitus from a specialized audiology clinic within the UK National Health Service (NHS) also had insomnia (Aazh et al, 2016;Aazh and Moore, 2017a;Aazh et al, 2017;. It has been reported that the emotional and cognitive distress caused by tinnitus has a significant relationship with the severity of sleep disturbances (Cronlein et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Parental Separation and Parental Mental Health in Childhood and Risk of Insomnia in Adulthood among Patients with Tinnitus

2020

Self Cite

View full text Add to dashboard Cite

Many patients seeking help for tinnitus also suffer from insomnia. Adverse childhood experiences may affect the likelihood of insomnia in later life for such patients.To explore whether parental separation and parental mental health during childhood are related to the severity of insomnia among patients with tinnitus and/or hyperacusis seen in an Audiology clinic.This was a retrospective cross-sectional study.One hundred seventy-four consecutive patients who attended a tinnitus/hyperacusis clinic in the United Kingdom were included.Data were based on responses to questionnaires for people seeking help for tinnitus.Sixteen percent of patients (27/174) reported that during the first 18 years of life, their parents were separated or divorced and 41% (72/174) reported that their parent(s) suffered from a mental illness. The mean score for the insomnia severity index (ISI) was not significantly affected by parental separation or divorce. However, the mean ISI score was significantly worse for patients whose parents had a mental illness. A multinomial logistic regression model, adjusted for the presence of hyperacusis, hearing loss, age, and gender, indicated that for individuals experiencing tinnitus, a history of parental mental illness during their childhood increased the chance of severe insomnia by a factor of 3.4 (95% confidence interval: 1.1 to 10.8, p = 0.04). The risk of having severe insomnia was 3.8 times greater for patients with hyperacusis than for those without.Among patients seeking help for tinnitus/hyperacusis, poor parental mental health was associated with severe insomnia.

show abstract

Factors Associated With Depression in Patients With Tinnitus and Hyperacusis

Cited by 43 publications

References 44 publications

Clinical Correlates of Insomnia in Patients with Persistent Post-Traumatic Headache Compared with Migraine

Clinical Correlates of Insomnia in Patients with Persistent Post-Traumatic Headache Compared with Migraine

Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine

Parental Separation and Parental Mental Health in Childhood and Risk of Insomnia in Adulthood among Patients with Tinnitus

Contact Info

Product

Resources

About