Factors Associated with Depressive Symptoms Among Rural Residents from Remote Areas

Conti, Catarine Lima; Borçoi, Aline Ribeiro; Almança, Carlos Cesar Jorden; Barbosa, Wagner Miranda; Archanjo, Anderson Barros; Pinheiro, Júlia de Assis; Freitas, Flávia Vitorino; Oliveira, Daniela Rodrigues de; Cardoso, Luciane Daniele; Paula, Heberth de; Silva, Adriana Madeira Álvares da

doi:10.1007/s10597-020-00637-0

Cited by 12 publications

(6 citation statements)

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“…Every symptom are rated on a 4-point scale ranging from 0 to 3, with higher scores indicating more severe symptoms of depression 48 . The values obtained were adequate to the total scores categorized according to the following regrouping used for primary care use population and non-clinical populations: minimal depression (BDI-II <10), mild depression (BDI-II 10-17) and depression (BDI-II ≥ 18) 3,49,50 .…”

Section: What Did the Researchers Do And Find?mentioning

confidence: 90%

“…According to the World Health Organization (WHO), in its action plan on mental health 2013-2020, one in ten people suffer from some mental health disorder in the world 1 , which main diseases are depression, bipolar affective disorder and schizophrenia 2 . Depression is a global public health concern, as 17% of the world's general population exhibits comorbidities 3,4 . In Brazil, this major depressive disorder has a prevalence of approximately 20% in São Paulo and 17% in Rio de Janeiro 5 .…”

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confidence: 99%

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Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Pinheiro

Borçoi

Freitas

et al. 2023

jhgd

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Introduction: Psychiatric disorders have become a global problem that leads millions of people to use psychotropic medications, especially benzodiazepines. The effects of these substances are widely known regarding tolerance and chemical dependence, however, from epigenetics perspective, there are still little known. Objective: To evaluate the association between psychotropic drug use, NR3C1 gene methylation and its relation with symptoms suggestive of depression in adult individuals assisted in the public health system. Methods: 385 adult volunteers (20-59 years) users of the Brazilian Unified Health System were recruited to evaluate socioeconomic, health, lifestyle conditions in a cross sectional study. BDI-II evaluated symptoms suggestive of depression and pyrosequencing evaluated NR3C1 DNA methylation. Bivariate and multivariate Poisson regression model with robust variance (p < 0.05) evaluated the association between psychotropic drug use and NR3C1 gene methylation. Results: Specific depressive symptoms such as irritability, insomnia and fatigability were associated with psychotropic drug use. Symptoms of past failure, indecision and loss of appetite were associated with hypermethylation patterns in CpGs 40 to 47 of NR3C1 gene. Moreover, psychotropic drug use is associated with 50% reduction in NR3C1 gene methylation, through model adjusted with socioeconomic, health and lifestyle confounding variables. Conclusions: Psychotropic drug use and depressive symptoms was associated with changes in NR3C1 DNA methylation. In this context, epigenetic modification resulting from psychotropic drug use and depressive symptoms could be considered, mainly in population studies with epigenetic evaluation, where these factors may be influencing the findings of future studies.

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Section: What Did the Researchers Do And Find?mentioning

confidence: 90%

mentioning

confidence: 99%

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Pinheiro

Borçoi

Freitas

et al. 2023

jhgd

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“…Notably, the effects of the sociodemographic variables observed in the study align with previous results. Speci cally, as identi ed in previous studies, female [43], rural [44], less educated [45], and unmarried [46] older adults are at increased risk for depressive symptoms and suicide [47].…”

Section: From Previous Researchmentioning

confidence: 96%

The Positive Effect of Retirement Pensions on Mental Health in Older Adults A nationally representative cross-sectional survey

zuo,

chen

2024

Preprint

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Background: Nowadays, there are 95 million people have symptoms of depression in China, and the rate of the old adults is 25.55%. Over the years, the Chinese government has introduced numerous social security programs including the social pension.Retirement pensions have been widely applied for older adults. To date, no evidence regarding the correlation between retirement pensions and depression in older adults in China has been published. Objective: This cross-sectional survey aimed to examine the relationship between retirement pensions and depression in older people. Methods: Province-level socioeconomic characteristics were merged with microdata for respondents over 60 years from the 2020 China Health and Retirement Longitudinal Study(CHARLS2020) Wave 5 (N = 8692). Respondents were asked if they were received retirement pension. Mental health was assessed using the 10-item Center for Epidemiological Studies Depression Scale. The chi-square test was used to explore whether retirement pensions were associated with mental health status. A binary logistic regression model was used to evaluate this association further after controlling for confounding factors. Results: Overall, 81% (7039/8692) of the participants over 60 years had retirement pensions. Regression analyses revealed that older adults with retirement pensions (OR = 0.677, 95% CI: 0.563–0.815, p < .001) had a lower risk of depression than did those without retirement pensions. In addition, older adults who were female, single, illiterate, and living in rural areas, had 2 chronic diseases and had very poor self-related health(SRH) had a greater risk of depression. For province-level characteristics, older adults living in provinces in the first quartile of the number of beds per 10,000 persons in medical institutions were more likely to experience depressive symptoms, while there was no significant effect(OR = 0.822, 95% CI: 0.664–1.018, p = .072) (OR = 0.752, 95% CI: 0.594–0.953, p = .018)(OR = 0.877, 95% CI: 0.703–1.093, p = .242) of GDP on depression. Conclusions: Retirement pensions had a positive effect on the mental health of older adults who participated in this study. Older adults with a retirement pension have a lower risk of depression than those without a retirement pension. However, the ownership rate of retirement pensions remains low among older Chinese people. Therefore, the retirement pension penetration rate should be a priority.

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“…However, epidemiological data are not available for all health issues. It has been documented that various chronic diseases and disorders occur after people have been exposed to pesticides [117][118][119], including cancers, adverse reproductive outcomes [120], male sterility [121], peripheral neuropathies [122], neurobehavioral disorders [123], impaired immune function (Nankongnab et al, 2020) [124], and allergic sensitization reactions, particularly of the skin [125][126][127]. Moreover, most of the pesticides examined affect male reproductive systems [124][125][126][127][128], causing sperm damage [118], DNA damage [129], and abnormal sperm morphology [13].…”

Section: Chronic Diseasementioning

confidence: 99%

Exposure Routes and Health Risks Associated with Pesticide Application

Tudi

et al. 2022

Toxics

136

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Pesticides play an important role in agricultural development. However, pesticide application can result in both acute and chronic human toxicities, and the adverse effects of pesticides on the environment and human health remain a serious problem. There is therefore a need to discuss the application methods for pesticides, the routes of pesticide exposure, and the health risks posed by pesticide application. The health problems related to pesticide application and exposure in developing countries are of particular concern. The purpose of this paper is to provide scientific information for policymakers in order to allow the development of proper pesticide application technics and methods to minimize pesticide exposure and the adverse health effects on both applicators and communities. Studies indicate that there are four main pesticide application methods, including hydraulic spraying, backpack spraying, basal trunk spraying, and aerial spraying. Pesticide application methods are mainly selected by considering the habits of target pests, the characteristics of target sites, and the properties of pesticides. Humans are directly exposed to pesticides in occupational, agricultural, and household activities and are indirectly exposed to pesticides via environmental media, including air, water, soil, and food. Human exposure to pesticides occurs mainly through dermal, oral, and respiratory routes. People who are directly and/or indirectly exposed to pesticides may contract acute toxicity effects and chronic diseases. Although no segment of the general population is completely protected against exposure to pesticides and their potentially serious health effects, a disproportionate burden is shouldered by people in developing countries. Both deterministic and probabilistic human health risk assessments have their advantages and disadvantages and both types of methods should be comprehensively implemented in research on exposure and human health risk assessment. Equipment for appropriate pesticide application is important for application efficiency to minimize the loss of spray solution as well as reduce pesticide residuals in the environment and adverse human health effects due to over-spraying and residues. Policymakers should implement various useful measures, such as integrated pest management (IPM) laws that prohibit the use of pesticides with high risks and the development of a national implementation plan (NIP) to reduce the adverse effects of pesticides on the environment and on human health.

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Factors Associated with Depressive Symptoms Among Rural Residents from Remote Areas

Cited by 12 publications

References 46 publications

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

The Positive Effect of Retirement Pensions on Mental Health in Older Adults A nationally representative cross-sectional survey

Exposure Routes and Health Risks Associated with Pesticide Application

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