Factors associated with diabetic polyneuropathy‐related sensory symptoms and signs in patients with polyneuropathy: A cross‐sectional Japanese study (JDDM 52) using a non‐linear model

Abstract

Aims/Introduction To assess the prevalence of diabetic polyneuropathy (DPN)‐related sensory symptoms/signs and associated factors in patients with polyneuropathy, considering non‐linear effects for numerical variables. Materials and Methods A cross‐sectional survey of patients with type 2 diabetes mellitus from 17 primary care clinics across Japan was carried out. DPN and DPN‐related sensory symptoms/signs were diagnosed according to the Diabetic Neuropathy Study Group in Japan criteria. Results Of the 9,914 patients with type 2 diabetes mellitus in this study, 2,745 had DPN and 1,689 had DPN‐related sensory symptoms/signs (61.5% of patients with DPN). There were significant correlations between DPN‐related sensory symptoms/signs and smoking status (odds ratio 2.04 for current and 1.64 for former; P < 0.001 and P = 0.002, respectively), sex (odds ratio 0.56 for male/female; P < 0.001) and alcohol consumption (odds ratio 2.02 for former/never; P = 0.004). Based on the non‐linear logistic regression model, significant correlations were observed between the presence of DPN‐related sensory symptoms/signs and higher systolic blood pressure (SBP), longer diabetes duration, and decreasing age. The logarithm of odds for SBP increased until reaching approximately 130 mmHg, then it plateaued. Conclusions Some modifiable factors assessed in the large survey database might be associated with DPN‐related sensory symptoms/signs, namely smoking, alcohol consumption and SBP. Maintaining SBP <130 mmHg was associated with lower odds of DPN‐related sensory symptoms/signs in patients with DPN.

Prevalence and Risk Factors of Sensory Symptoms in Diabetes Patients in Taiwan

“…It is not known whether the higher prevalence of SS in women than in men was due to sex difference in the thresholds of sensory perception. A female preponderance of pDPN was also observed in the Korean study (7) and the Japanese study (10). Animal in vitro and in vivo studies suggested that estradiol may upregulate the nocisensor transient receptor potential (TRP) vanilloid 1 receptor in sensory neurons, resulting in lowered thresholds of sensation (28).…”

“…In a cross-sectional study that aimed at investigating the prevalence of diabetic retinopathy in 1,008 diabetes patients enrolled from a hospital in Shijiazhuang, Hebei, China, the investigators reported a prevalence of 11% for DPN among the patients and found a close association between DPN and diabetic retinopathy ( 9 ). Another recently published cross-sectional study that enrolled patients from 17 primary care clinics across Japan showed a prevalence of 27.7% for DPN among 9,914 patients surveyed ( 10 ). Among the patients with DPN, 61.5% had DPN-related sensory symptoms/signs, which were significantly associated with female sex, smoking, and alcohol drinking ( 10 ).…”

“…Another recently published cross-sectional study that enrolled patients from 17 primary care clinics across Japan showed a prevalence of 27.7% for DPN among 9,914 patients surveyed ( 10 ). Among the patients with DPN, 61.5% had DPN-related sensory symptoms/signs, which were significantly associated with female sex, smoking, and alcohol drinking ( 10 ).…”

A Cross-sectional Survey of Patients with Suspected Diabetic Peripheral Neuropathic Pain in Japan

“…Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus ( 1 ), with an estimated prevalence in patients with diabetes mellitus of 28% in the US ( 2 , 3 ), between 6% and 34% in Europe ( 4 ), and between 28% and 37% in Japan ( 5 - 7 ). Diabetic peripheral neuropathic pain (DPNP), one of the symptoms of DPN, is associated with numbness, pain, and abnormal sensation often occurring below the knees of both legs ( 8 ).…”

Risk factors associated with Loss of Protective Sensitivity in Diabetes patients in the Multidisciplinary Unit of Diabetic Foot

“…La polineuropatía diabética es una de las complicaciones más comunes de la DM y su prevalencia es de aproximadamente 37 a 45% en personas con DM tipo 2 y 54 a 59% en personas con DM tipo 1 (9). En Francia, se describe que el 87% de los pacientes ingresados por pie diabético sufren de neuropatía y aún en centros especializados llegan a una tasa de amputación del 48% (10).…”