Factors Associated with Early Severe Intraventricular Haemorrhage in Very Low Birth Weight Infants

Vela-Huerta, Ma Martha; Amador-Licona, Norma; Medina-Ovando, N.; Aldana-Valenzuela, Carlos

doi:10.1055/s-0030-1248249

Cited by 27 publications

(20 citation statements)

References 22 publications

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“…Regardless of IUGR, lower GA was an important predictor of NBAs, which was in line with the results of previous studies [13,21]. Considering that some neonates may not have IVH during the first days after birth, but after admission to the neonatal intensive care unit following postbirth events, such as respiratory problems and respiratory distress syndrome in particular, have been recognized as important risk factors in the development of germinal matrix hemorrhage-IVH [22,23], we wanted to examine the course of IVH in these infants over time, similar to Cruz-Martinez et al [13].…”

Section: Discussionsupporting

confidence: 89%

Predictors of Cranial Ultrasound Abnormalities in Intrauterine Growth-Restricted Fetuses Born between 28 and 34 Weeks of Gestation: A Prospective Cohort Study

et al. 2018

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Background: Doppler parameters have been commonly used for the prediction of neonatal outcomes. However, controversies exist with regard to the value of Doppler parameters in predicting the risk of neurological outcomes among neonates. Objective: This prospective cohort study attempted to assess the value of Doppler parameters in predict ing cranial ultrasound abnormalities (CUAs) in intrauterine growth restriction (IUGR) among fetuses at 28–34 weeks of gestation. Methods: This was a prospective cohort study of 83 delivered IUGR fetuses and 75 control fetuses matched for gestational age (GA). The value of mentioned Doppler parameters and GA in predicting the risk of CUAs, including periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH), and basal ganglia lesions (BGLs), was analyzed. Results: The incidence of CUAs among IUGR fetuses (66.3%) was significantly higher (p < 0.001) than in the control group (40%). The incidence of neonatal mortality among IUGR fetuses was significantly higher (p < 0.001) than in the control group. Absent or reversed end-diastolic velocity (AREDV) in the umbilical artery (UA) and the ductus venosus (DV) after adjustment for GA was associated with increased odds of IVH, PVL, BGLs, and any CUA. Conclusions: GA at birth and AREDV in the UA and the DV within 1 week before childbirth were reliable predictors of CUAs during the neonatal period.

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Section: Discussionsupporting

confidence: 89%

Predictors of Cranial Ultrasound Abnormalities in Intrauterine Growth-Restricted Fetuses Born between 28 and 34 Weeks of Gestation: A Prospective Cohort Study

et al. 2018

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“…Despite the increasing survival rate of premature infants during recent decades, IVH is still one of the major causes of neurologic developmental problems (24)(25)(26). Inadequate functioning of autoregulation of cerebral blood flow has been considered as pathogenic factor in IVH (8).…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume as a Marker of Intraventricular Hemorrhage in Very Premature Infants

et al. 2017

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Background: Since the intraventricular hemorrhage (IVH) is still a serious problem in premature infants associated with poor neurodevelopmental outcomes, there is a need for an accessible tool in order to identify these at high risk neonates. Objectives: To determine if high mean platelet volume (MPV) within 24 hours of birth can identify preterm infants prone to IVH as a simple accessible test. Methods: One hundred premature infants with gestational age (GA) of < 34 weeks with respiratory distress syndrome (RDS) were eligible in this study and were divided into two groups based on the diagnosis of IVH. Measurements of MPV and platelet counts

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“…In almost 90% cases, IVH occurs in the first 4 d of life (1). Several studies found an association between cardiovascular instability immediately after birth and IVH in VLBW infants (2)(3)(4)(5)(6).…”

mentioning

confidence: 99%

“…Circulatory management in the neonatal intensive care unit (NICU) mainly focuses on elevation of blood pressure (6,7). Several studies have identified an association between hypotension and poor neurodevelopmental outcomes (1,3).…”

mentioning

confidence: 99%

Skin blood flow as a predictor of intraventricular hemorrhage in very-low-birth-weight infants

et al. 2013

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Background: Cardiovascular instability immediately after birth is associated with intraventricular hemorrhage (IVH) in very-low-birth-weight (VLBW) infants. For circulatory management, evaluation of organ blood flow is important. In this study, the relationship between peripheral perfusion within 48 h after birth and IVH was evaluated in VLBW infants. Methods: In this prospective observational study involving 83 VLBW infants, forehead blood flow (FBF) and lower-limb blood flow (LBF) were measured for 48 h after birth using a laser Doppler flowmeter. Blood flow was compared between infants with and without IVH. Multivariate logistic regression analysis was performed to identify the risk factors for IVH. results: IVH developed in nine infants. In eight of these patients, IVH occurred after 24 h. LBF was lower in infants with IVH at 18 and 24 h and increased to the same level as that of infants without IVH at 48 h. Multivariate logistic regression analysis identified a correlation only between LBF and IVH at 18 h. conclusion: These findings were consistent with the hypoperfusion-reperfusion theory, which states that IVH develops after reperfusion subsequent to hypoperfusion. We speculate that measurement of skin blood flow in addition to systemic and cerebral circulation may be helpful in predicting IVH.

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Factors Associated with Early Severe Intraventricular Haemorrhage in Very Low Birth Weight Infants

Abstract: Birth weight and arterial hypotension were factors related to early IVH grade III, whereas hypercapnia and large BE were factors related to IVH grade IV in VLBW infants.

Cited by 27 publications

References 22 publications

Predictors of Cranial Ultrasound Abnormalities in Intrauterine Growth-Restricted Fetuses Born between 28 and 34 Weeks of Gestation: A Prospective Cohort Study

Predictors of Cranial Ultrasound Abnormalities in Intrauterine Growth-Restricted Fetuses Born between 28 and 34 Weeks of Gestation: A Prospective Cohort Study

Mean Platelet Volume as a Marker of Intraventricular Hemorrhage in Very Premature Infants

Skin blood flow as a predictor of intraventricular hemorrhage in very-low-birth-weight infants

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