Factors associated with febrile seizures among children

Tarhani, Fariba; Nezami, Alireza; Heidari, Ghobad; Dalvand, Niloufar

doi:10.1016/j.amsu.2022.103360

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Выделяют два сезонных пика заболеваемости ФС: ноябрь-январь, соответствующий подъёму заболеваемости вирусных инфекций верхних дыхательных путей, и июнь-август, когда возникают распространённые вирусные желудочно-кишечные инфекции [10,11]. Некоторые исследования выявили более высокую частоту ФС у мальчиков, хотя другие авторы не обнаружили существенных различий при этой патологии в зависимости от пола [12,13].…”

Section: For Citationunclassified

“…ФС представляют собой неврологическое нарушение, возникающее в результате инфекционного процесса, которое порождает воспалительную реакцию и лихорадку [2,3,19,20]. Повышение температуры вызывает повышение возбудимости нейронов, нарушение нейротрансмиссии, что приводит к судорогам [3,13,21]. Отмечено что ФС возникают преимущественно у детей в возрасте до 3-х лет, которые имеют низкий судорожный порог [21].…”

Section: результаты и обсуждение факторы риска (этиология)unclassified

“…Вирусы, чаще всего вызывающие ФС, включают: вирус герпеса человека 6 типа (детская розеола), гриппа, аденовирус и вирус парагриппа [18,30]. Некоторые клинические исследования показали, что инфекция верхних дыхательных путей была определена как самый распространенный триггер (81,6 %) при ФС, за которым следовали острый гастроэнтерит (15,4 %) и инфекция мочевыводящих путей (3 %) [13,22]. Среди 108 детей, с вирусным гастроэнтеритом и судорогами, у 49 (45,4 %) был диагностирован ФС, тогда как у 59 (54,6 %) наблюдались афебрильные судороги [31].…”

Section: результаты и обсуждение факторы риска (этиология)unclassified

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Febrile seizures in pediatric practice: Risk factors, clinical manifestations, and intensive therapy

Bykov,

Obedin,

Fischer

et al. 2023

Урал. мед. журнал

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Introduction. Febrile seizures (FS) is the most common type of epileptic seizure experienced by young children. Study of methods of intensive treatment (IT) of FS represents a vital area of research in today’s pediatric science. The aim of this work: to assess the current approaches to risk factors, clinical manifestations and emergency care for patients with FS in pediatric practice. Materials and methods. The authors performed an analysis of publications that were found in the Cochrane Library, PubMed, eLibrary.ru, and Medscape databases using the following search terms: febrile seizures, children and adolescents, intensive treatment, anticonvulsants. A total of 64 published sources were chosen for review. Results and Discussion. The risk factors for FS may be numerous, with the main etiological causes in children being genetic susceptibility, viral infections and vaccination. The clinical presentation of FS is characterized by the development of a generalized tonic-clonic seizure in the setting of a high body temperature (≥39°C). FS are subdivided into three main clinical types: simple, complex and febrile status epilepticus (FSE). History taking and physical examination represent the main diagnostic means for determining the type of FS and discovering the cause of infection. Laboratory tests, electroencephalography, neuroimaging studies and lumbar puncture are used on a limited basis, mainly in children with complicated FS accompanied by a brain infection. Hospitalization for IT is necessary if the child has prolonged febrile seizures or FSE. The drugs of choice for relieving FS are benzodiazepines. Barbituric acid derivatives and valproic acid also possess therapeutic efficacy against FS. Antipyretic agents are effective only in relieving the toxic syndrome, but have no effect on the severity of FS and do not prevent relapses. The main antipyretic medications used for treatment of FS in pediatric practice are paracetamol, ibuprofen and nimesulide. Besides benzodiazepines, IT of FSE involves the use of intravenous fosphenytoin, phenobarbital or levetiracetam. Conclusion. Improvement of the quality of IT in pediatric practice may improve the therapeutic prognosis in patients with FS and bring down complication and mortality rates.

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Section: For Citationunclassified

Section: результаты и обсуждение факторы риска (этиология)unclassified

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Febrile seizures in pediatric practice: Risk factors, clinical manifestations, and intensive therapy

Bykov,

Obedin,

Fischer

et al. 2023

Урал. мед. журнал

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“…Viral infections involving the ear, nose, throat, and upper respiratory tract are the most frequent causative events of fever-associated seizures. In a retrospective study, Tarhani et al ( 18 ) have reported on 77 children affected by FS that in these children the mean duration of seizures was 5.09 +/– 3.78 minutes and the mean temperature during seizures was 38.41 +/– 0.83 °C. In 44 (57.14%) children no cause of the fever was documented.…”

Section: Fever-associated Seizures or Epilepsy (Fase)mentioning

confidence: 99%

Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions

et al. 2022

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In addition to central nervous system infections, seizures and fever may occur together in several neurological disorders. Formerly, based on the clinical features and prognostic evolution, the co-association of seizure and fever included classical febrile seizures (FS) divided into simple, complex, and prolonged FS (also called febrile status epilepticus). Later, this group of disorders has been progressively indicated, with a more inclusive term, as “fever-associated seizures or epilepsy” (FASE) that encompasses: (a) FS divided into simple, complex, and prolonged FS; (b) FS plus; (c) severe myoclonic epilepsy in infancy (Dravet syndrome); (d) genetic epilepsy with FS plus; and (e) febrile infection-related epilepsy syndrome (FIRES). Among the FASE disorders, simple FS, the most common and benign condition, is rarely associated with subsequent epileptic seizures. The correlation of FS with epilepsy and other neurological disorders is highly variable. The pathogenesis of FASE is unclear but immunological and genetic factors play a relevant role and the disorders belonging to the FASE group show to have an underlying common clinical, immunological, and genetic pathway. In this study, we have reviewed and analyzed the clinical data of each of the heterogeneous group of disorders belonging to FASE.

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“…Studies have shown that recurrent FS may increase the risk of temporal lobe epilepsy, psychiatric disease, and even death [ 4 , 5 ]. The occurrence of FS has been linked to inflammation, familial history, and deficiencies of certain elements (iron, selenium, and zinc) [ [6] , [7] , [8] , [9] ]. In clinical practice, anticonvulsant drugs, such as phenobarbital, diazepam, and valproic acid, have been used to treat FS [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

An integrated strategy of UPLC-Q-TOF-MS analysis, network pharmacology, and molecular docking to explore the chemical constituents and mechanism of Zixue Powder against febrile seizures

Song,

Xu,

Shi

et al. 2024

Heliyon

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Factors associated with febrile seizures among children

Cited by 7 publications

References 21 publications

Febrile seizures in pediatric practice: Risk factors, clinical manifestations, and intensive therapy

Febrile seizures in pediatric practice: Risk factors, clinical manifestations, and intensive therapy

Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions

An integrated strategy of UPLC-Q-TOF-MS analysis, network pharmacology, and molecular docking to explore the chemical constituents and mechanism of Zixue Powder against febrile seizures

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