Factors associated with fertility intention among women with systemic lupus erythematosus in China: A cross‐sectional study

Liang, Qian; Wang, Xingxin; He, Qian; Ni, Xiaowei; Zhao, Rui; Ji, Juan; Dong, Chen; Gu, Zhifeng

doi:10.1111/1756-185x.14927

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…The orbidity rate is higher in women, and men were more likely than women to experience end-organ damage and die. 2,3 Among all the influencing factors, the relationship between obesity and SLE has been widely studied, but it has not been fully clarified. A cross-sectional study showed that smoking is independently related to SLE, but body mass index (BMI) score is not related to SLE risk.…”

Section: Introductionmentioning

confidence: 99%

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The causal associations of inflammatory cytokines with obesity and systemic lupus erythematosus: A Mendelian randomization study

Huang,

Zhou,

2024

Int J of Rheum Dis

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ObjectivePrevious studies have partly discussed the roles of inflammatory cytokines in obesity and systemic lupus erythematosus (SLE), but the causal relationship among inflammatory cytokines, obesity, and SLE is unclear. It is challenging to comprehensively evaluate the causal relationship between these variables. This study aimed to investigate the role of cytokines as intermediates between obesity and SLE.MethodsThe inverse‐variance weighted method (IVW) of mendelian randomization (MR) is mainly used to explore the causal relationship between exposure and outcome by using the genetic variation of the open large genome‐wide association studies (GWAS), namely single‐nucleotide polymorphisms (SNPs) related to obesity (more than 600 000 participants), inflammatory cytokines (8293 healthy participants) and SLE (7219 cases). Methods such as weighted median, MR‐Egger are used to evaluate the reliability of causality. Reverse analysis is performed for each MR analysis to avoid reverse causality. Cochran's Q statistic and funnel chart are used to detect heterogeneity, MR‐Egger intercept test and leave‐one‐out sensitivity analyses evaluated pleiotropy.ResultsObesity was associated with 25 cytokines, and 3 cytokines were associated with SLE, including CTACK (OR = 1.19, 95% CI: 1.06, 1.33, p = .002), IL‐18 (OR = 1.13, 95% CI: 1.01, 1.26, p = .027), SCGFb (OR = 0.89, 95% CI: 0.79, 0.99, p = .044). In the opposite direction, SLE was associated with 18 cytokines, and 2 cytokines were associated with obesity, including IP‐10 (βIVW = −.03, 95% CI: −0.05, −0.01, p = .002), MIP‐1B (βIVW = −.03, 95% CI: −0.05, −0.01, p = .004).ConclusionOur MR study suggested that CTACK, IL‐18 and SCGFb may play an intermediary role in obesity to SLE, while IP‐10 and MIP‐1B may play an intermediary role in SLE to obesity.

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Section: Introductionmentioning

confidence: 99%

“…Gender was related to SLE risk as well. The orbidity rate is higher in women, and men were more likely than women to experience end‐organ damage and die 2,3 . Among all the influencing factors, the relationship between obesity and SLE has been widely studied, but it has not been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

The causal associations of inflammatory cytokines with obesity and systemic lupus erythematosus: A Mendelian randomization study

Huang,

Zhou,

2024

Int J of Rheum Dis

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Exploring the understanding and experience of women with rheumatic diseases regarding fertility intention- a qualitative content analysis

Manouchehri,

Larki,

Sahebari

2024

BMC Women's Health

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Background Patients with rheumatic diseases (RDs) have a lower desire to have children, fewer children, and a longer interval between their pregnancies, which can be due to the patient’s personal choice, the physician’s advice, changes in sexual activity, changes in fertility, and pregnancy failure. This study aimed to explore the understanding and experience of women with RDs regarding pregnancy intention. Method In Mashhad, Northeast Iran, between December 2022 and March 2023, this qualitative inquiry was carried out. Purposive sampling was used to select thirty women with RDs. Semi-structured interviews were used to collect the data. Graneheim and Lundman’s conventional content analysis method was used to analyze the data. The data organization was done using MAXQDA 12 software. Credibility, dependability, confirmability, and transferability have been considered as elements of trustworthiness. Results The participants’ data analysis revealed the following main theme: “duality of desire and fear in childbearing”. Five main categories were identified, including “Individual health concerns following pregnancy”, “motherhood and womanhood perceptions”, “concerns about child harm”, “contradictory beliefs and attitudes of significant family members and clinicians about pregnancy”, and “lack of social support for fertility”. Conclusion In order to improve the outcomes of pregnancy for women with RDs, the medical professionals who manage them must actively and frequently inquire about their intentions to childbearing and offer them individualized guidance on how to be in the best possible health at the time of conception. Rheumatologists, gynecologists, and reproductive health specialists can better address the sexual and reproductive health needs of this population by enhancing their collaboration in the care of women with RDs.

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Factors associated with fertility intention among women with systemic lupus erythematosus in China: A cross‐sectional study

Cited by 2 publications

References 49 publications

The causal associations of inflammatory cytokines with obesity and systemic lupus erythematosus: A Mendelian randomization study

The causal associations of inflammatory cytokines with obesity and systemic lupus erythematosus: A Mendelian randomization study

Exploring the understanding and experience of women with rheumatic diseases regarding fertility intention- a qualitative content analysis

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