Factors Associated with Foot Lesions in Diabetic Patients at Saint-Louis Hospital (Senegal): A Case-Control Study Protocol

Abstract

Introduction: Diabetes prevalence has increased over the past years. In Senegal, this prevalence is 4% in the general population. However, the region of Saint-Louis (in the north of the country) has the highest rate with 10.4%. The main prognosis problem is the occurrence foot lesions that can lead to lower-limbs amputation. Diabetic foot is a real public health issue, due to its economic burden and its serious repercussions on patients, leading to poor quality of life. The objective of this case-control study is to identify factors associated with foot lesions in diabetic patients. Methods and analysis:It will be a case-control study from January to December 2021. The patients will be recruited from the departments of general surgery, internal medicine, and emergency. An univariate then multivariate analysis (logistic regression) will allow us to select the variables associated with foot lesions in our study population. The parameters included in the logistic regression will be those with a p < 0.20 in the univariate analysis. Finally, a binary logistic regression analysis (with the calculation of Odds Ratios (OR) with confidence intervals (CI)) according to the backward stepwise method will identify the factors independently associated to foot lesions in diabetic patients. Ethics and dissemination:This research protocol will be submitted to the Ethics Committee of our institution for approval. The knowledge of factors causing diabetic foot will help to communicate with policymakers to raise the awareness in our community. Finally, it will help to prevent lower limb amputations. Highlights• Diabetes is the leading cause of non-traumatic lower-limb amputation in the world.• The region of Saint-Louis (Senegal) has the highest prevalence of diabetes.• Controlling factors associated with foot lesions in diabetic patients can prevent from amputation.

Efficacy of Sitagliptin and Recombinant Bovine Basic Fibroblast Growth Factor Gel in the Treatment of Chronic Diabetic Foot Ulcers

“…Poor blood glucose control in diabetics can lead to many complications in the long run. Diabetic foot lesions are a common condition associated with diabetes, manifested as stenosis or even complete occlusion of the distal vascular space of the affected limb due to poor blood circulation below the ankle joint and peripheral neuropathy [17] . When secondary infection of the foot and ischemic ulcers are developed, then the disease progresses to DFUs.…”