Factors associated with health-related quality of life in chronic leg ulceration

Importance Bites from the brown recluse spider (BRS) can cause extreme pain. We propose cytokine release as a cause of the discomfort and a central mechanism through glial cell upregulation to explain measured pain levels and time course. Observations Twenty-three BRS bites were scored at a probable or documented level clinically, and an enzyme-linked immunosorbent assay was used to confirm the presence of BRS venom. The mean (SD) pain level in these cases 24 hours after the spider bite was severe: 6.74 (2.75) on a scale of 0 to 10. Narcotics may be needed to provide relief in some cases. The difference in pain level by anatomic region was not significant. Escalation observed in 22 of 23 cases, increasing from low/none to extreme within 24 hours, is consistent with a cytokine pain pattern, in which pain increases concomitantly with a temporal increase of inflammatory cytokines. Conclusions and Relevance These findings in BRS bites support the hypothesis of cytokine release in inflammatory pain. A larger series is needed to confirm the findings reported here. The extreme pain from many BRS bites motivates us to find better prevention and treatment techniques.

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“…Anecdotal evidence suggests that discomfort levels with time approach those in chronic leg ulcers: 2.9 of 10. 15 …”

Section: Discussionmentioning

confidence: 99%

Extreme Pain From Brown Recluse Spider Bites

et al. 2014

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“…, Hopman et al . ). The majority of individuals with this condition are treated by nurses in the community care setting (Harrison et al .…”

Section: Introductionmentioning

confidence: 97%

Health‐related quality of life at healing in individuals with chronic venous or mixed‐venous leg ulceration: a longitudinal assessment

Hopman

VanDenKerkhof

Carley

et al. 2016

Journal of Advanced Nursing

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“…The costs of chronic wounds in Australia are considerable, equivalent to more than AUD $3.5 billion, approximately 2% of national health care expenditure . Chronic wounds can also have a major negative impact on the health‐related quality of life (HRQoL) of affected individuals …”

Section: Introductionmentioning

confidence: 99%

Chronic wounds in Australia: A systematic review of key epidemiological and clinical parameters

McCosker

Tulleners

Cheng

et al. 2018

International Wound Journal

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Chronic wounds are a significant problem in Australia. The health care‐related costs of chronic wounds in Australia are considerable, equivalent to more than AUD $3.5 billion, approximately 2% of national health care expenditure. Chronic wounds can also have a significant negative impact on the health‐related quality of life of affected individuals. Studies have demonstrated that evidence‐based care for chronic wounds improves clinical outcomes. Decision analytical modelling is important in confirming and applying these findings in the Australian context. Epidemiological and clinical data on chronic wounds are required to populate decision analytical models. Although epidemiological and clinical data on chronic wounds in Australia are available, these data have yet to be systematically summarised. To address these omissions and clarify the state of existing evidence, we conducted a systematic review of the literature on key epidemiological and clinical parameters of chronic wounds in Australia. A total of 90 studies were selected for inclusion. This paper presents a synthesis of the evidence on the prevalence and incidence of chronic wounds in Australia, as well as rates of infection, hospitalisation, amputation, healing, and recurrence.

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Factors associated with health-related quality of life in chronic leg ulceration

Cited by 42 publications

References 21 publications

Extreme Pain From Brown Recluse Spider Bites

Extreme Pain From Brown Recluse Spider Bites

Health‐related quality of life at healing in individuals with chronic venous or mixed‐venous leg ulceration: a longitudinal assessment

Chronic wounds in Australia: A systematic review of key epidemiological and clinical parameters

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