Factors associated with health‐related quality of life in pediatric cancer survivors

Meeske, Kathleen; Patel, Sunita K.; Palmer, S; Nelson, Mary Baron; Parow, Aimee

doi:10.1002/pbc.20923

Cited by 178 publications

(192 citation statements)

References 36 publications

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“…Eiser et al (30) reported unfavorable quality of life scores in adolescent CNS cancer patients whose treatment was completed when compared with ALL patients, most prominently observed in the physical and psychosocial subscale scores. In this study, lower quality of life scores in patients with CNS were detected, comparable to the study outcomes reported by Meeske et al (31) and Chou et al (32). This result is associated with the location of the tumor and neurocognitive changes caused by surgery and radiotherapy.…”

Section: Discussionsupporting

confidence: 91%

A prospective follow-up of quality of life, depression, andanxiety in children with lymphoma and solid tumors

Yildirim¹,

Demirkaya²,

Sevinir³

et al. 2017

Turk J Med Sci

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The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors.Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used.Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and in the group of patients whose diagnosis was delayed for more than 3 months. Total quality of life scores for children and their parents were 82.

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Section: Discussionsupporting

confidence: 91%

A prospective follow-up of quality of life, depression, andanxiety in children with lymphoma and solid tumors

Yildirim¹,

Demirkaya²,

Sevinir³

et al. 2017

Turk J Med Sci

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“…Mixed race/ethnicity was associated with lower Psychosocial Health Summary scores, although the basis for this association is unclear. Previous studies have reported a decreased HRQOL in children of ethnic minorities with chronic illnesses, specifically in the psychosocial realm (37)(38).…”

Section: Comparison Of Family Impact Module Results With Scores Repormentioning

confidence: 86%

Health‐Related Quality of Life in Children With Intestinal Failure

Sanchez¹,

McAteer²,

Goldin³

et al. 2013

J. pediatr. gastroenterol. nutr.

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“…However, other studies have found that brain tumors and treatments (like cranial radiation), which have an impact on cognitive function, were associated with long term emotional distress for survivors (26)(27)(28)(29)(30). It may be that intensity of treatment in general, and cranial radiation in very young children in particular, is related to late effects which impair function and cause emotional distress.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Stuber

Meeske

Zebrack

et al. 2009

JCO

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Objective-Recent studies have found that a subset of young adult survivors of childhood cancer report posttraumatic stress symptoms in response to their diagnosis and treatment. However, it is unclear if these symptoms are associated with impairment in daily functions and/or significant distress, thereby resulting in a clinical disorder. Furthermore, it is unknown whether this disorder continues into very long-term survivorship, including the 3 rd and 4 th decades of life. This study hypothesized that very long-term survivors of childhood cancer would be more likely to report symptoms of posttraumatic stress disorder, with functional impairment and/or clinical distress, compared to a group of healthy siblings.Patients and Methods-6,542 childhood cancer survivors over the age of 18 who were diagnosed between 1970 and 1986 and 368 siblings of cancer survivors completed a comprehensive demographic and health survey.Results-589 survivors (9%) and 8 siblings (2%) reported functional impairment and/or clinical distress in addition to the set of symptoms consistent with a full diagnosis of Posttraumatic Stress Disorder (PTSD). Survivors had more than a four-fold risk of PTSD compared to siblings (OR=4.14, 95%CI: 2.08-8.25). Controlling for demographic and treatment variables, increased risk of PTSD was associated with educational level of high school or less (OR=1.51, 95% CI=1.16-1.98), being unmarried (OR=1.99, 95% CI=1.58-2.50), annual income less than $20,000Address correspondence to Margaret L. Stuber at UCLA Semel Institute, 760 Westwood Plaza, Los Angeles, CA 90024-1759. Telephone: 310 825-5213, Fax: 310 206-4446, mstuber@mednet.ucla (4), one symptom of re-experiencing, three avoidance symptoms, and two symptoms of increased arousal must be present. In addition, symptoms must be severe enough to cause clinical distress or functional impairment. Symptoms must also be in response to an event that ended at least one month prior to assessment, was perceived as a threat to life or body integrity of self or a loved one, and elicited feelings of horror, intense fear or helplessness.Previous studies of PTSD in childhood cancer survivors have found a minority of survivors reporting significant symptoms, with as few as 3% of survivors 8 to 20 years old (1) to 20% in young adult survivors (2). Compared to a rate of 8.6% in a recent study of 965 adults attending a primary care clinic (5), young adult survivors, but not younger survivors, appeared to have a significantly increased prevalence of PTSD symptoms. Although no formal assessment of clinical distress or functional impairment was done as a part of the diagnosis, the young adult survivors who reported symptoms of PTSD were less likely to be married, and reported more psychological distress and poorer quality of life across all domains (6). Similar impairments in function have also been described in people with PTSD within the general population (5, 7).Subsequent studies of PTSD in adult survivors of childhood cancer with sample sizes ranging from 45 to 368 ha...

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Factors associated with health‐related quality of life in pediatric cancer survivors

Cited by 178 publications

References 36 publications

A prospective follow-up of quality of life, depression, andanxiety in children with lymphoma and solid tumors

A prospective follow-up of quality of life, depression, andanxiety in children with lymphoma and solid tumors

Health‐Related Quality of Life in Children With Intestinal Failure

Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

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