Factors associated with hospital mortality in renal transplant patients admitted to
            the intensive care unit with acute respiratory failure

Silva, Rafael Mendes da; Freitas, Flávio Geraldo Rezende; Bafi, Antônio Tonete; Silva, Hélio Tedesco; Roza, Bartira de Aguiar

doi:10.5935/0101-2800.20170076

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…The present study showed that the chance of an individual with heart failure dying or going to the ICU is 18.3 times greater than that of an individual without heart failure (Table 4). Although, several studies have compared the clinical outcomes of patients who underwent kidney transplantation [9][10][11][12][13]. No evidence addresses the impact of heart failure on the death and ICU stay in pulmonary infection post-transplant.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Mortality and Admission in Intensive Care for Kidney and Kidney-Pancreas Transplant Recipients with Respiratory Infection

de Faria,

Nobre

2023

J Pulmonol Res Rep

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Background and Objective: Kidney transplantation is a therapy of choice for chronic kidney disease at an advanced stage, however, such intervention has postoperative complications and adverse effects related to immunosuppressive therapy, namely infectious conditions. This study aims to investigate risk factors for mortality and admission to intensive care in kidney transplant recipients with respiratory tract infections.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Mortality and Admission in Intensive Care for Kidney and Kidney-Pancreas Transplant Recipients with Respiratory Infection

de Faria,

Nobre

2023

J Pulmonol Res Rep

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“…As per our study, various studies have shown that advanced graft dysfunction is significantly associated with mortality in RTR. [ 27 28 ]…”

Section: Discussionmentioning

confidence: 99%

Aetiology, management, and outcome of lower respiratory tract infection in renal allograft recipients – A report from a tropical country

Bhadauria¹,

Jain²,

Prasad³

et al. 2022

Lung India

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Introduction: Lower respiratory tract infections (LRTIs) among renal transplant recipients (RTRs) are a significant cause of morbidity and mortality. This study aimed to analyse the aetiology, outcome, and risk factors associated with mortality. Methods: We analysed baseline transplant characteristics, symptoms, hospital course, laboratory, serological and microbial results, and their association with the outcome of all RTRs between January 2011 and December 2019. Results: A total of 206 LRTI patients out of 1051 RTRs were analysed. The incidence proportion was nearly 22 episodes per 1000 patients per year. The mean age was 39.3 years, with male predominance. Bacterial was the most common aetiology (53%), and staphylococcus was the most common species. Among the fungal causes (14%), 68% had aspergillus infection. More than one-third RTRs died during the hospital course mainly because of bacterial causes (42.6%). The aspergillus infection was the most common fungus associated with 50% mortality. On multi-variate analysis, sepsis, septic shock, and the need for mechanical ventilation independently predicted mortality. Conclusion: Bacterial aetiology was the most common cause; though the fungal aetiology was seen less, it was associated with higher mortality. Mortality in RTR with LRTI was associated with sepsis, septic shock, and the need for mechanical ventilation.

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“…Both in-hospital and 90-day mortality rates were 22.5% [23]. A more recent retrospective study of 183 KTRs admitted to the ICU for acute respiratory failure found the need for vasopressor drugs [odds ratio (OR) 8.13, P < 0.001], mechanical ventilation (OR 3.87, P ¼ 0.016) and a Simplified Acute Physiology Score (SAPS) 3 (OR 1.04, P ¼ 0.045) were associated with mortality in the multivariate analysis [24].…”

Section: Pneumoniasmentioning

confidence: 99%

Management of the kidney transplant recipient in the intensive care unit

Voora,

Shah,

Nadim

2023

Current Opinion in Critical Care

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Purpose of review Kidney transplantation is the ideal treatment for patients with chronic kidney disease and end stage renal disease. While centers are performing more transplants every year, the need for organ transplantation outpaces the supply of organ donors Due to a growing population of patients with advanced kidney disease and a scarcity of kidneys from deceased donors, patients face extended wait times. By the time patients approach transplantation they have multiple comorbidities, in particular cardiovascular complications. Their risk of complications is further compounded by exposure to immunosuppression post kidney transplantation. Kidney transplant recipients (KTRs) are medically complex and may require acute management in the intensive care unit (ICU), as a result of cardiovascular complications, infections, and/or respiratory compromise from lung infections and/or acute pulmonary edema. Acute complication of immunosuppression, such as thrombotic microangiopathy and posterior reversible encephalopathy syndrome may also warrant ICU admission. This review will cover assessment of high-risk complications and management strategies following kidney transplantation. Recent findings For intensivists caring for KTRs, it is imperative to understand anatomical considerations of the transplanted kidney, unique infectious risks faced by this population, and appropriate modulation of immunosuppression. Summary Recognizing potential complications and implementing appropriate management strategies for KTRs admitted to the ICU will improve kidney allograft and patient survival outcomes.

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Factors associated with hospital mortality in renal transplant patients admitted to the intensive care unit with acute respiratory failure

Abstract: Keywords: intensive care units; kidney transplantation; respiratory insufficiency.

Cited by 3 publications

References 27 publications

Factors Associated with Mortality and Admission in Intensive Care for Kidney and Kidney-Pancreas Transplant Recipients with Respiratory Infection

Factors Associated with Mortality and Admission in Intensive Care for Kidney and Kidney-Pancreas Transplant Recipients with Respiratory Infection

Aetiology, management, and outcome of lower respiratory tract infection in renal allograft recipients – A report from a tropical country

Management of the kidney transplant recipient in the intensive care unit

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