Factors associated with Mediterranean diet adherence in Huntington's disease

Rivadeneyra, J; Cubo, Esther; Gil, Cecilia; Calvo, Sara; Mariscal, Natividad; Martínez, Asunción

doi:10.1016/j.clnesp.2016.01.001

Cited by 20 publications

(16 citation statements)

References 20 publications

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“…Some studies investigated the nutritional status of people with HD to determine whether micronutrient and macronutrient intake helped in improving disease symptoms or delaying disease progression [ 18 , 30 , 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

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Dietary Intake, Mediterranean Diet Adherence and Caloric Intake in Huntington’s Disease: A Review

2020

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Decades of research and experimental studies have investigated Huntington’s disease (HD), a rare neurodegenerative disease. Similarly, several studies have investigated whether high/moderate adherence to the Mediterranean Diet and specific macro and micronutrients can decrease cognitive loss and provide a neuroprotective function to neurons. This review systematically identifies and examines studies that have investigated Mediterranean Diet adherence, micro- and macronutrients, supplementation and caloric intake in people with HD, in order to identify if dietary exposures resulted in improvement of disease symptoms, a delay in age of onset or if they contributed to an earlier age of onset in people with HD. A systematic search of PubMed, Directory of open access journal and HubMed was performed independently by two reviewers using specific search terms criteria for studies. The identified abstracts were screened and the studies were included in the review if they satisfied predetermined inclusion criteria. Reference screening of included studies was also performed. A total of 18 studies were included in the review. A few studies found that patients who had high/moderate adherence to Mediterranean Diet showed a slight improvement in their Unified Huntington’s Disease Rating Scale and Total Functional Capacity. In addition, people with HD who had high Mediterranean Diet adherence showed an improvement in both cognitive and motor scores and had a better quality of life compared to patients who had low Mediterranean Diet adherence. Furthermore, a few studies showed that supplementation with specific nutrients, such as triheaptanoin, L-acetyl-carnitine and creatine, had no beneficial effect on the patients’ Unified Huntington’s Disease Rating Scale score. A few studies suggest that the Mediterranean Diet may confer a motor and cognitive benefit to people with HD. Unfortunately, there was little consistency among study findings. It is important for more research to be conducted to have a better understanding of which dietary exposures are beneficial and may result delaying age of onset or disease progression in people with HD.

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Section: Resultsmentioning

confidence: 99%

“…Similar studies in HD mouse models were excluded. Furthermore, the studies, that investigated and assessed MD adherence such as Rivadeneyra et al, 2016 and Marder et al, 2013, used the Trichopoulou score with a range of 0–9 to assess MD adherence [ 16 , 18 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Dietary Intake, Mediterranean Diet Adherence and Caloric Intake in Huntington’s Disease: A Review

2020

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“…An observational multicenter Spanish dietary intake study reported that in advanced HD patients, an adequate dietary intake protected against UWL, although this intake was not associated with better neurofunctional state . However, in HD‐moderate patients, who self‐reported dietary intake using a 3‐day dietary record, an association was found between Mediterranean diet adherence, and quality of life, lower comorbidity, and motor impairment compared to those participants with low adherence …”

Section: Resultsmentioning

confidence: 99%

“…[16] However, in HD-moderate patients, who self-reported dietary intake using a 3-day dietary record, an association was found between Mediterranean diet adherence, and quality of life, lower comorbidity, and motor impairment compared to those participants with low adherence. [34] In our study, body composition was measured in nine of 11 participants, all of whom showed an increase in fat mass. Four had a mass increase of between 0.1 and 0.9 kg, and in the other five between 1.3 and 9.1 kg.…”

Section: Body Weight and Compositionmentioning

confidence: 94%

Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease

Aganzo

Montojo

Hazas

et al. 2018

Molecular Nutrition Food Res

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Scope Huntington's disease (HD) is a rare progressive neurodegenerative disorder of genetic origin, with no definitive treatment. Unintentional weight loss (UWL) is a clinical feature of symptomatic HD subjects. To prevent UWL, a customized HD diet is designed and its impact on plasma miRNA HD footprint and neurological parameters is examined. Methods and results Eleven participants are included, BMI ≤ 18 kg m–2 or UWL of 5% in 6 months or 10% in a year. Diet design is based on nutritional surveys and interviews of participants and caregivers and on published literature review. Twelve‐month dietary intervention, with follow‐up every 3 months, induces high diet adherence, which manages to curb UWL in all participants (73% gained weight). Noticeable increases in fat mass and leptin levels are obtained. The results also show significant decrease in the expression of 19 miRNAs, which are previously reported to be upregulated in HD‐patients versus healthy controls: revealing hsa‐miR‐338‐3p, hsa‐miR‐128‐3p, hsa‐miR‐23a‐3p, and hsa‐miR‐24‐3p as potential HD‐biomarkers. The diminished expression of hsa‐miR‐100‐5p reflects the general maintenance of the functional status. Cognitive status is improved in six of 11 participants, while only three present better motor‐score values. Conclusion A customized HD‐diet prevents UWL and modified miRNAs HD‐footprint. The normalization of miRNA values suggests its potentially use as HD‐biomarkers.

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“…A diet with high glycemic index or high glycemic load should not be advised because it increases OS (Abou‐Seif & Youssef, ; De Carvalho Vidigal, Guedes Cocate, Goncalves Pereira, & Gonçalves Alfenas, ). Instead, the Mediterranean diet should be recommended as it decreases OS (Dai et al, ; Mitjavila et al, ), and adherence confers significant benefits for HD patients (Rivadeneyra et al, ). Coffee consumption should not be recommended especially for people with HD genetic predisposition because evidence suggests that habitual caffeine intake is associated with earlier age at onset in HD (Olcina et al, ; Simonin et al, ).…”

Section: Conclusion and Clinical Recommendationsmentioning

confidence: 99%

Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington's disease

Tobore

2019

J of Neuroscience Research

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Huntington's disease (HD) is a rare autosomal dominant disorder affecting the corticostriatal area of the brain. HD is driven by elongated cytosine-adenine-guanine (CAG) repeat (36 repeats or more) on the short arm of chromosome 4p16.3 in the Huntingtin gene (HTTg) which encode the huntingtin protein (HTT). Although the polyglutamine expansion within HTT is the causative factor in the pathogenesis of HD, the underlying mechanisms that provoke this expansion and the resulting neurodegeneration and clinical symptoms are not fully understood. In this paper, the critical role played by mitochondria dysfunction and oxidative stress in HTT expansion, HD progression, and clinical symptoms are elucidated. Their interactions with the key factors in the disease, as well as treatment strategies, are discussed.

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Factors associated with Mediterranean diet adherence in Huntington's disease

Cited by 20 publications

References 20 publications

Dietary Intake, Mediterranean Diet Adherence and Caloric Intake in Huntington’s Disease: A Review

Dietary Intake, Mediterranean Diet Adherence and Caloric Intake in Huntington’s Disease: A Review

Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease

Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington's disease

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