Factors associated with mortality among patients with active pulmonary tuberculosis requiring intensive care

Loh, Wann Jia; Yu, Yue; Loo, Chian Min; Low, Su Ying

doi:10.11622/smedj.2016160

Cited by 16 publications

(31 citation statements)

References 29 publications

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“…com). 1,5,6,18,21,[23][24][25]27,28,31,40,41,43,44 The common indications for the use of glucocorticoids were miliary tuberculosis, respiratory failure, ARDS, and shock. Eight studies compared mortality in subjects with and without glucocorticoids (Supplemental Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies compared mortality in subjects with and without glucocorticoids (Supplemental Table 2). 1,5,24,27,28,40,43,44 Only one study provided the details of dose and duration of glucocorticoids (methylprednisolone, 80 mg/d for 5 d) used. 5…”

Section: Resultsmentioning

confidence: 99%

“…1 at http://www.rcjournal.com). 5,6,16,18,24,25,32,40 The pooled proportion of all subjects with tuberculosis as an indication for ICU admission was 2.3% (95% CI 1.1-4, I 2 ϭ 95.5%, P Ͻ .001). 7,17,19,22,28,35…”

Section: Pooled Proportion Of Subjects With Tuberculosis Who Were Crimentioning

confidence: 98%

“…The mortality of subjects with tuberculosis who are critically ill varied from 17 to 67%. [1][2][3][5][6][7] The pooled ICU (26 studies [n ϭ 1,282]) 2,3,[5][6][7]18,19,[23][24][25][26]38,[40][41][42]44 and hospital mortality (23 studies [n ϭ 1,283]) 1,3,16,17,[20][21][22][23][24][25][26]28,31,33,[36][37][38][39][40][42][43][44] was 48% (95% CI 41-55%, I 2 ϭ 86.11%, P Ͻ .001) and 54% (95% CI 46 -62%, I 2 ϭ 92.58%, P Ͻ .001), respectively (Fig. 2).…”

Section: Pooled Effectmentioning

confidence: 99%

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Outcome of Critically Ill Subjects With Tuberculosis: Systematic Review and Meta-Analysis

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Pooled Proportion Of Subjects With Tuberculosis Who Were Crimentioning

confidence: 98%

Section: Pooled Effectmentioning

confidence: 99%

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Outcome of Critically Ill Subjects With Tuberculosis: Systematic Review and Meta-Analysis

et al. 2018

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“…An increasing proportion (3-16%) of patients diagnosed with active tuberculosis (TB) require intensive care [1][2][3]. In countries with high TB and human immunodeficiency virus (HIV) burden [i.e.…”

Section: Introductionmentioning

confidence: 99%

The role of mini-bronchoalveolar lavage fluid in the diagnosis of pulmonary tuberculosis in critically ill patients

et al. 2020

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Background: The detection of Mycobacterium tuberculosis (MTB) in the intensive care unit (ICU) presents several challenges, mainly associated to the clinical state of the patient. The presence of HIV infection further aggravates this scenario, requiring a reliable collection method, with better performance in the microbiological/molecular techniques to be used. We evaluated the performance of two methods for sample collection, mini bronchoalveolar lavage (Mini-BAL) and endotracheal aspirate (ETA), for diagnosis of pulmonary tuberculosis (PTB) in critically ill patients.Methods: This prospective study involved 26 HIV positive ICU internalized patients, with presumptive PTB who required mechanical ventilation. Two samples were obtained prospectively from 26 HIV ICU patients with presumptive PTB by Mini-BAL and ETA. The samples were processed for smear microscopy, Löwenstein-Jensen medium and the BACTEC Mycobacteria Growth Indicator Tube 960 system®. We define as confirmed PTB patients with positive MTB culture. Furthermore, all samples obtained through the Mini-BAL were analyzed by Xpert® MTB/RIF. Results: Our results demonstrated that the respiratory samples obtained by Mini-BAL were able to increase MTB detection in critically ill patients with presumptive PTB. The Mini-BAL allowed 30% increased recovery and guaranteed enough sample volume for processing in all methods. In addition, the larger volume of the samples obtained with this technique enabled the Xpert® MTB/RIF molecular test for diagnosis of TB. Conclusions:The Mini-BAL showed be an acceptable alternative to ETA in this population, since these critically ill and often-immunocompromised patients are more likely to develop complications related to invasive procedures.

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Clinical presentation and outcome of patients diagnosed with active tuberculosis in a critical care unit

Ramos

Arana

2021

Acta Colombiana de Cuidado Intensivo

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Factors associated with mortality among patients with active pulmonary tuberculosis requiring intensive care

Cited by 16 publications

References 29 publications

Outcome of Critically Ill Subjects With Tuberculosis: Systematic Review and Meta-Analysis

Outcome of Critically Ill Subjects With Tuberculosis: Systematic Review and Meta-Analysis

The role of mini-bronchoalveolar lavage fluid in the diagnosis of pulmonary tuberculosis in critically ill patients

Clinical presentation and outcome of patients diagnosed with active tuberculosis in a critical care unit

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