Factors associated with mortality outcomes in neonatal septicemia in Srinagarind hospital, Thailand

Tareen, Zarghoon

doi:10.18535/jmscr/v5i8.114

JMSCR

2017

DOI: 10.18535/jmscr/v5i8.114

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Factors associated with mortality outcomes in neonatal septicemia in Srinagarind hospital, Thailand

Zarghoon Tareen¹

Abstract: ABSTRUCT (OR 12.237, P<0.001) and 5 min (OR 13.143, P <0.001), VLBW (OR 5.312, P 0.001) , EOS (3.749, P 0.001), prematurity (2.723, P 0.01), and out born delivery (6.253, P<0.001), were all significantly associated with fatality. Laboratory results showed that hyperglycemia (OR 6.213, P 0.001) and thrombocytopenia (3.853, P 0.002)

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2024

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Risk factors for mortality due to neonatal sepsis: a systematic review and meta-analysis

Miranda,

Harahap,

Husada

et al. 2024

F1000Res

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Background Certain risk factors have been shown to increase the mortality of patients with neonatal sepsis. This study aimed to determine the risk factors for neonatal sepsis-related mortality. Methods Google Scholar, MEDLINE, ProQuest, ScienceDirect, and Scopus databases were searched to identify relevant literature from 2014 to 2023. Observational analytical studies in English that reported the risk factors for neonatal sepsis mortality were chosen. We assessed the risk of bias by using the checklists of the Joanna Briggs Institute. Fixed-effect models were used when the number of included studies was <5; otherwise, random-effects models were employed. Heterogeneity was evaluated using the I2 statistic. Publication bias was assessed using a funnel plot, and a sensitivity analysis was performed. Statistical significance was set at P <0.05. Analyses were conducted using the RevMan 5.4.1. Results Twelve out of 40,587 articles included a total of 2232 patients. The majority of patients were male (50.4%–70%). The I2 statistics showed no heterogeneity across studies for sex, gestational age, birth weight, or requirement for inotropic support. History of invasive ventilation (OR = 35.06 [16.84–72.99]), requirement for inotropic support (OR = 18.04 [8.38–38.81]), low 1st minute Apgar score (OR = 4.93 [2.1–11.58]), convulsive (OR = 4.69 [2.03–10.82]), poor feeding (OR = 3.95 [2.12–7.33]) episodes, preterm birth (OR = 3.63 [2.78–4.74]), low birth weight (OR = 3.02 [1.58–5.75]), early onset sepsis (OR = 2.52 [1.74–3.64]), and lethargy (OR = 2.14 [1.5–3.04]) were associated with neonatal sepsis mortality. Conclusions A history of invasive ventilation use, requirement for inotropic support, low 1st minute Apgar score, convulsions, poor feeding episodes, preterm birth, low birth weight, early onset sepsis, and lethargy were identified as significant risk factors for neonatal sepsis mortality. Clinicians must be vigilant to improve outcomes and prevent death.

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Risk factors for mortality due to neonatal sepsis: a systematic review and meta-analysis

Miranda,

Harahap,

Husada

et al. 2024

F1000Res

View full text Add to dashboard Cite

show abstract

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Factors associated with mortality outcomes in neonatal septicemia in Srinagarind hospital, Thailand

Cited by 1 publication

References 10 publications

Risk factors for mortality due to neonatal sepsis: a systematic review and meta-analysis

Risk factors for mortality due to neonatal sepsis: a systematic review and meta-analysis

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