Factors associated with multiple contact allergies in Thai dermatitis patients: A 10‐year retrospective study

Winayanuwattikun, Waranaree; Boonchai, Waranya

doi:10.1111/cod.13189

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…These restrictions are expected to positively impact contact allergy rates soon, as evidenced by the declining MI rates in our study and Europe 29 . Regarding multiple contact allergies, both males and females displayed equal outcomes (16%), aligning with our previous study, which concluded that gender was not a risk factor for multiple contact allergies 31 …”

Section: Discussionsupporting

confidence: 89%

“…29 Regarding multiple contact allergies, both males and females displayed equal outcomes (16%), aligning with our previous study, which concluded that gender was not a risk factor for multiple contact allergies. 31 We emphasised the importance of patients bringing their PCPs for patch testing, which resulted in a PCP-positive rate of 13% in our study. Regarding patients' PCPs, females tended to use more products, which increased the chances of allergen exposure and the development of contact allergy.…”

Section: Discussionmentioning

confidence: 96%

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Gender differences in allergic contact dermatitis to common allergens

Boonchai,

Likittanasombat,

Viriyaskultorn

et al. 2023

Contact Dermatitis

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BackgroundGender‐based differences in skin structure, physiology, and allergen exposure can influence contact dermatitis development.ObjectiveThis study investigated the differences and trends in contact sensitizers, focusing on the top 10 allergens and personal care product (PCP) contact allergies from a gender perspective.MethodsWe conducted a retrospective chart review of 5998 patients undergoing patch testing at an occupational and contact dermatitis clinic in a Thai, university‐based, tertiary referral hospital from January 2001 to December 2021. Patients' characteristics and patch test results were collected.ResultsFemales had a higher positive patch test rate than males (71.8% vs. 65%, p < 0.001). However, males showed a greater prevalence of occupationally related allergic contact dermatitis (15.9%). Multivariate analysis revealed associations between being female and allergies to colophonium (aOR 1.46, 95% CI 1.07–1.99, p = 0.019), formaldehyde (aOR 1.97, 95% CI 1.17–13.31, p = 0.010), fragrance mix I (aOR 1.66, 95% CI 1.34–2.07, p < 0.001), MCI/MI (aOR 2.55, 95% CI 1.90–3.44, p < 0.001), neomycin (aOR 4.15, 95% CI 2.54–6.80, p < 0.001), and nickel (aOR 2.62, 95% CI 2.17–3.15, p < 0.001). Conversely, being male correlated with allergies to carba mix (aOR 0.51, 95% CI 0.41–0.64, p < 0.001), epoxy resin (aOR 0.26, 95% CI 0.14–0.47, p < 0.001), n‐isopropyl‐n‐phenyl‐4‐phenylenediamine (aOR 0.41, 95% CI 0.20–0.83, p = 0.014), paraben mix (aOR 0.42, 95% CI 0.32–0.56, p < 0.001), and potassium dichromate (aOR 0.70, 95% CI 0.58–0.84, p < 0.001). Positive reactions to PCPs stood at 13% overall (males 17.1%, females 12.2%, p < 0.001).ConclusionsGender plays a pivotal role in contact dermatitis. This work emphasises the importance of considering gender‐specific factors when diagnosing and managing contact allergies.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Gender differences in allergic contact dermatitis to common allergens

Boonchai,

Likittanasombat,

Viriyaskultorn

et al. 2023

Contact Dermatitis

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“…Concomitant positive reactions and polysensitization to the fragrance allergens were also frequently found 21,22 . As illustrated in Figure 1, most patients reacted to only one allergen; however, many of the tested patients had positive reactions to more than one allergen.…”

Section: Discussionmentioning

confidence: 87%

Prevalence, concomitant reactions, and factors associated with fragrance allergy in Thailand

et al. 2020

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Background Fragrances are the most common cause of cosmetic contact allergy. Up‐to‐date information on contact allergy frequencies and relevance aids primary and secondary preventive measures. Objectives To determine the prevalence, associated factors, and concomitant reactions in fragrance allergy among Thais. Methods This retrospective study collected data from 2012 to 2019. The patient characteristics of fragrance and nonfragrance allergy groups were compared. Concurrent positive reactions to fragrance allergens (fragrance mix [FM] I, FM II, Myroxylon pereirae resin and hydroxyisohexyl 3‐cyclohexene carboxaldehyde) and other baseline‐series allergens were analysed. Results Of 1032 patients, 175 (17.0%) had fragrance allergy, with 57.7% of clinical relevance. FM I showed the highest prevalence (9.4%). The associated factors were being elderly, lesions on the extremities, metal allergy history, and long dermatitis duration. Contact allergies to epoxy resin and Compositae plants were significantly associated with fragrance allergy with an odds ratio of 5.95 (95% confidence interval [CI]: 5.21‐6.80) and an odds ratio of 4.42 (95% CI: 1.58‐12.36), respectively. No significant associations between colophonium (previously proposed as a fragrance marker) and fragrance allergens were found. Conclusions The prevalence of fragrance contact allergy remains high and should be considered in old patients presenting with long‐standing eczema on the extremities. Unlike reports from other countries, varied, significant, concomitant reactions were observed.

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Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019–2022 prospective study with cluster and network analysis

Pesqué,

Borrego,

Zaragoza‐Ninet

et al. 2024

Acad Dermatol Venereol

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BackgroundThere is still limited clinical‐practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS).ObjectivesTo determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation.MethodsProspective multicentric study (January 2019–December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC). Clinical and patch test data of polysensitized and oligosensitized patients were compared, and risk factors of PS were investigated with logistic multivariate regression. Unsupervised hierarchical clustering and network analysis were used to study allergen aggregation in PS.ResultsA total of 10,176 patients were analysed. PS was found in 844 (8.3%). Current relevance was significantly higher in polysensitized patients (p < 0.01). Risk factors for PS were atopic dermatitis (OR: 1.58, 95% CI: 1.24–2.02), age (≥60 years vs. ≤24 years, OR: 1.75, 95% CI: 1.25–2.44) and some special locations (legs vs. face OR: 1.54, 95% CI: 1.05–2.25, hands vs. face OR: 1.46, 95% CI:1.15–1.85, arms vs. face OR: 1.49, 95% CI:1.01–2.20, trunk vs. face OR: 1.40, 95% CI:1.06–1.85). Cluster and network analyses revealed specific‐allergen clusters and significant associations, including allergens belonging to metals group, fragrances and botanicals group, topical drugs group, rubber allergens and biocides.ConclusionsThis study confirms that PS is structured by discernible patterns of specific‐allergen clusters and reinforces significant allergen associations in PS. Cross‐reactivity and/or concomitant sensitization could explain the formation of allergen clusters in PS.

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Factors associated with multiple contact allergies in Thai dermatitis patients: A 10‐year retrospective study

Cited by 3 publications

References 22 publications

Gender differences in allergic contact dermatitis to common allergens

Gender differences in allergic contact dermatitis to common allergens

Prevalence, concomitant reactions, and factors associated with fragrance allergy in Thailand

Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019–2022 prospective study with cluster and network analysis

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