Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis

Mirsadraee, Raheleh; Khajedaluee, Mohammad; Vakili, Rahim; Hasanabade, Azam; Saeedrezaee, Zahra

doi:10.17795/jpr-7462

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The majority of participants have poor knowledge about the DKA risk factors and only a few had good knowledge, which is in line with a study by Mirsadraee in Iran. [ 9 ] We recommend the health department authorities to emphasize the main risk factors that have a direct relation with DKA.…”

Section: Discussionmentioning

confidence: 99%

Level of awareness of diabetic ketoacidosis among diabetes mellitus patients in Riyadh

Farran¹,

Elaiwah²,

Aldarsouny³

et al. 2020

J Family Med Prim Care

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Background: Diabetic ketoacidosis (DKA) is considered to be a serious acute life-menacing complication of diabetes type (1) and type (2). The study aims to assess the level of awareness regarding DKA among diabetic patients in the Riyadh population. Methodology: The study is an institution-based cross-sectional study with a sample size of 150 participants. The participants are chosen through systemic random sampling, who have type (1) or type (2) diabetes mellitus patients and are 18–35 years of age. The medical personnel were excluded from the study. A self-administered, precoded, and pretested questionnaire was developed especially for this study after consulting literature and epidemiologists containing data about the risk factor, management, and complication. Data were analyzed using (SPSS). A P value of less than 0.05 was considered significant. Results: 38.67% (58) participants have poor awareness regarding complications, 67.34% (101) have poor knowledge regarding management, and 6% (9) participants have a good knowledge, 38% (57) participants have poor knowledge regarding risk factors and 30% (45) of the participants have good awareness. The relation between having a first degree relative with diabetes and awareness regarding management is significant with a P value of 0.022; 73% (110) of the participants had no relatives with diabetes mellitus and 71% (79) had a poor level of awareness regarding the management of DKA. However, 55% (22) of respondents who had relatives with diabetes mellitus also had a poor level of awareness regarding treatment. Conclusion: The majority of the participants had a poor level of awareness. There is a relationship between having a first-degree relative with diabetic mellitus and the level of awareness regarding DKA.

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Section: Discussionmentioning

confidence: 99%

Level of awareness of diabetic ketoacidosis among diabetes mellitus patients in Riyadh

Farran¹,

Elaiwah²,

Aldarsouny³

et al. 2020

J Family Med Prim Care

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“…In the current study all the patients were 199, among them there was 54 new patients, 190 patients (95.47%) participated in this study, and the incidence rate (12.11/100,000) was higher as compared to another study in Basrah city, Southern Iraq, (7.4 per 100,000 (95% CI, 7.1-8.1). 5 Japan (2.2/100,000), Iran (3.7/100,000), and lower compared to, United Kingdom (26/100,000) 2 Saudi Arabia (33.5/100,000). 7 While prevalence (44.65/100,000) was higher compared to study in South-Eastern Nigerian school children aged 5-17 years.…”

Section: Incidence and Prevalencementioning

confidence: 96%

“…The first presentation of 10-70% of newly diagnosed children with DM1 is Diabetic Ketoacidosis (DKA). 1,2 The incidence rates differ in different populations, the lowest is observed in Venezuela and China while the highest in Sardinia and Finland. Regarding T1D incidence among Arab countries, several studies reported low incidence in Oman (2.54/100,000) and high incidence in Saudi Arabia (29/100,000).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological profile and diabetes control of Type 1 Diabetes Mellitus patients in Karbala Governorate, Iraq

et al. 2023

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Background: Type1 Diabetes Mellitus is a common chronic diseases among children, and associated with morbidity, mortality, and enormous healthcare expenditures. Objectives; to estimate the prevalence, incidence, and describe the epidemiological characteristics of Type 1 Diabetes Mellitus among children in Karbala governorate, Methods: A cross-sectional study was conducted among all children who attended the main DM center in Karbala Teaching Hospital for Children, Public Clinics, and Primary Health Care centers. Data was collected by structured questionnaire and biochemical and anthropometric measurements. The statistical analysis data entry was conducted using Statistical Package for Social Sciences. Results: Total number of Type 1 Diabetes Mellitus patients aged 0-15 years in Karbala in 2015 was 199; making 44.66/1005. Fifty-four patients were newly diagnosed patients making an incidence of 12.11/1005. There was nearly equal distribution among both sexes. Most of the cases were from urban areas and most of the patients had a Family history of Type 2 Diabetes Mellitus. Diabetic ketoacidosis was reported in 16.8% of the patients. Only 31.6% of patients had HbA1c < 7%. Half of the patients had a history of admission to the hospital for diabetes. Logistic regression analysis revealed that the only independent variables significantly correlated with poor glycemic control were lack of Self-Monitoring Blood Glucose, irregular visits to the Diabetic Center, and positive family history of diabetes. Conclusion: Only one-third of T1DM children in Karbala city had controlled blood sugar. Lack of regular blood glucose monitoring and irregular contact with health care providers were the main determinants of uncontrolled blood sugar.

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Factors Associated With Diabetic Ketoacidosis at Onset of Type 1 Diabetes Among Pediatric Patients

et al. 2022

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ImportancePresenting with diabetic ketoacidosis (DKA) at onset of type 1 diabetes (T1D) remains a risk. Following a 2011 systematic review, considerable additional articles have been published, and the review required updating.ObjectiveTo evaluate factors associated with DKA at the onset of T1D among pediatric patients.Evidence ReviewIn this systematic review, PubMed, Embase, Scopus, CINAHL, Web of Science, and article reference lists were searched using the population, intervention, comparison, outcome search strategy for primary research studies on DKA and T1D onset among individuals younger than 18 years that were published from January 2011 to November 2021. These studies were combined with a 2011 systematic review on the same topic. Data were pooled using a random-effects model.FindingsA total of 2565 articles were identified; 149 were included, along with 46 from the previous review (total 195 articles). Thirty-eight factors were identified and examined for their association with DKA at T1D onset. Factors associated with increased risk of DKA were younger age at T1D onset (&lt;2 years vs ≥2 years; odds ratio [OR], 3.51; 95% CI, 2.85-4.32; P &lt; .001), belonging to an ethnic minority population (OR, 0.40; 95% CI, 0.21-0.74; P = .004), and family history of T1D (OR, 0.46; 95% CI, 0.37-0.57; P &lt; .001), consistent with the 2011 systematic review. Some factors that were not associated with DKA in the 2011 systematic review were associated with DKA in the present review (eg, delayed diagnosis: OR, 2.27; 95% CI, 1.72-3.01; P &lt; .001). Additional factors associated with risk of DKA among patients with new-onset T1D included participation in screening programs (OR, 0.35; 95% CI, 0.21-0.59; P &lt; .001) and presentation during the COVID-19 pandemic (OR, 2.32; 95% CI, 1.76-3.06; P &lt; .001).Conclusions and RelevanceIn this study, age younger than 2 years at T1D onset, belonging to an ethnic minority population, delayed diagnosis or misdiagnosis, and presenting during the COVID-19 pandemic were associated with increased risk of DKA. Factors associated with decreased risk of DKA included greater knowledge of key signs or symptoms of DKA, such as a family history of T1D or participation in screening programs. Future work should focus on identifying and implementing strategies related to these factors to reduce risk of DKA among new patients with T1D.

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Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis

Cited by 5 publications

References 26 publications

Level of awareness of diabetic ketoacidosis among diabetes mellitus patients in Riyadh

Level of awareness of diabetic ketoacidosis among diabetes mellitus patients in Riyadh

Epidemiological profile and diabetes control of Type 1 Diabetes Mellitus patients in Karbala Governorate, Iraq

Factors Associated With Diabetic Ketoacidosis at Onset of Type 1 Diabetes Among Pediatric Patients

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