Factors Associated with Non-Adherence to Antiretroviral Therapy among HIV-Infected Adolescents at Pediatric Department of Yopougon University Hospital, C&amp;#244;te d’Ivoire

Eboua, Tanoh Kassi François; Nouaman, Marcellin; Aké-Assi, M.H.; Bleu, Yvette; Kouadio, B.; Niamien, E.; Adonis-Koffy, L.

doi:10.4236/ojped.2018.83025

Cited by 3 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Makadzange et al, in Zimbabwe in 2012 in a study involving 418 adolescents reported a 33% rate of virologic failure among ALHIV on ART [ 14 ]. Similarly, alarming rates of VF have been reported among ALHIV, ranging from 34.2% (n = 92/270) in Cameroon in 2019, 41.8% (n = 69/165) in Côte d’Ivoire in 2017 to 51.6% (n = 86/167) in Togo in 2014 [ 15 , 21 , 22 ]. However, the distribution of VF was very heterogeneous, and varied from one health facility to another.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rate of virological failure and HIV-1 drug resistance among HIV-infected adolescents in routine follow-up on health facilities in Cameroon

Penda

Mbonjo²,

Fokam³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

The objective of this study was to determine the rates of virological failure (VF) and HIV drug resistance (HIVDR) amongst adolescents on antiretroviral Therapy (ART). A retrospectively designed study was conducted in 10 healthcare centers for adolescents living with HIV (ALHIV) in the two main cities of Cameroon (Yaoundé and Douala), from November 2018 to May 2019. Sociodemographic, clinical, therapeutic and laboratory parameters were collected from medical records. All enrolled ALHIV had viral load (VL) measurements following the national guidelines. All patients with a VL ≥ 1000 copies/ml were called to perform genotyping tests. The chi-square test was used to determine the factors associated with VF. Out of the 1316 medical records of ALHIV, we included 1083 ALHIV having a VL result. Among them, 276 (25.5%) were experiencing VF, and VF was significantly higher in ALHIV with suboptimal adherence (p<0.001), older adolescents (p<0.05), those who lived outside the city where they were receiving ART (p<0.006), severely immunocompromised (p<0.01) and started ART at infancy (p<0.02). Among the 45/276 (16.3%) participants with an available genotyping resistance testing (GRT) result, the overall rate of HIVDR was 93.3% (42/45). The most common mutations were K103N (n = 21/42, 52.3%) resulting in high-level resistance to Efavirenz and Nevirapine, followed by M184V (n = 20/42, 47.6%) and thymidine analog mutations (n = 15/42, 35.7%) associated with high-level resistance to Lamivudine and Zidovudine respectively. The high rate of VF and HIVDR among ALHIV regularly followed in health facilities in Cameroon highlights the need to develop interventions adapted to an adolescent-centered approach to preserve future ART options.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The median age of ART duration in our study was 7 years, suggesting significant exposure to first-line regimens based on reverse transcriptase inhibitor with a low genetic barrier. Sub-optimal adherence to ART is often associated with VF in children and adolescents on ART [ 22 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Rate of virological failure and HIV-1 drug resistance among HIV-infected adolescents in routine follow-up on health facilities in Cameroon

Penda

Mbonjo²,

Fokam³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…However, the task requires careful assessment of the status of adherence and age specific factors. 21 Studies on adherence to ART and associated factors among children below 15 years of age are limited in Ethiopia, in general and in the study area. Additionally, adherence is not static and can vary with time on treatment, making assessing adherence status crucial.…”

Section: Introductionmentioning

confidence: 99%

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

Gemechu,

Hebo,

Kura

2023

HIV

View full text Add to dashboard Cite

Background Poor adherence to antiretroviral therapy (ART) causes drug resistance, treatment failure and death. Studies conducted among children below 15 years were limited in Ethiopia in general and in the study area. Therefore, this study aimed to assess the status of children’s adherence to ART and associated factors in the study area. Methods We conducted a facility-based cross-sectional study from April 1 to May 10, 2020 by including 282 children <15 years. All children who received ART for at least one month and attend ART clinic during data collection period were consecutively recruited. Face-to-face interview was conducted using a standardized questionnaire. Both bivariate and multivariate logistic regression were performed. Adherence and exposure variables (i.e., sociodemographic and reason for missing) were measured by the caregivers/children’s report of a one-month recall of missed doses. Results Among 282 caregivers included with their children, 226 (80.2%) were females (mean age = 38.6 and SD = 12.35) and half (50%) of children were females. Two hundred forty six (87.2%) children were aged between 5–14 years (mean age = 8.5 and SD = 2.64), and 87.2% were adhered (≥95%) to ART in the month prior to the interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than their counterparties. Children whose caregivers were biological parents were 2.37 (95% CI: 1.59, 3.3) times more adherent than children with non-biological parents. Children with knowledgeable caregivers about ART were 4.5 (95% CI: 1.79, 9.8) times more adherent to ART. Conclusion and Recommendation Children’s adherence to ART in our study area was sub optimal. Biological caregivers, residing in urban and being knowledgeable about ART facilitate adherence to ART. Adherence counseling targeting non-biological parents and for those who come from rural areas were recommended.

show abstract

“…In general, the authors are interested in the factors explaining the variations in prevalence from one region to another in Côte d'Ivoire (Essis et al, 2022) or the factors linked to the transmission of HIV between the infected mother and the new born (N'guessan et al, 2017). Other work focuses on the low adherence of adolescents to Anti-Retroviral (ARV) treatments among young people (Eboua et al, 2018). In the professional environment, the work deals with the mixed contribution of companies to the fight against the pandemic (Bekelynck, 2014) which could be explained by the constraints suffered by them due to deaths and also the lack of care appropriate for Workers Living with HIV (PLHIV) (Aventin, 1998).…”

Section: Introductionmentioning

confidence: 99%

HIV/AIDS and Discrimination in Access to and Maintenance of Employment: The Case of PLHIV<sup>1</sup> in the Localities of Abidjan and Bouaké, Ivory Coast

Appiah¹

2022

JSS

View full text Add to dashboard Cite

Faced with the difficulties of access to employment and the discrimination suffered by Person Living with HIV (PLHIV) in the world of work, the Ivorian legislator took measures in the mid-2010s to protect them. And yet, these practices persist. Based on a case study of two localities (Abidjan and Bouaké), the article attempts to uncover these discriminations and at the same time grasp the root causes of these practices. The aim is to establish a relationship between the discrimination experienced by PLHIV in the world of work and that in society. The text is based on a literature review and a qualitative survey carried out with 41 key informants through 4 focus groups and 9 individual interviews with PLHIV workers (focus groups), Non-Governmental Organizations (NGOs), workers' organizations (unions) and employers (OE) and heads of Government Services (SG). The article concludes that discrimination in access to and maintenance of employment against People Living with HIV (PLHIV) in the world of work is the extension of current practices in society. They are accentuated when it comes to specific vulnerable groups. Key populations, in particular LGBT face double discrimination: one related to their sexual orientation and another to their HIV status.

show abstract

Factors Associated with Non-Adherence to Antiretroviral Therapy among HIV-Infected Adolescents at Pediatric Department of Yopougon University Hospital, Côte d’Ivoire

Abstract: Context: The consequences of non-adherence to antiretroviral therapy (ART) are harmful in terms of morbidity and mortality among HIV-infected adolescents. There is a little data in this population in West Africa, about

Cited by 3 publications

References 23 publications

Rate of virological failure and HIV-1 drug resistance among HIV-infected adolescents in routine follow-up on health facilities in Cameroon

Rate of virological failure and HIV-1 drug resistance among HIV-infected adolescents in routine follow-up on health facilities in Cameroon

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

HIV/AIDS and Discrimination in Access to and Maintenance of Employment: The Case of PLHIV<sup>1</sup> in the Localities of Abidjan and Bouaké, Ivory Coast

Contact Info

Product

Resources

About

Factors Associated with Non-Adherence to Antiretroviral Therapy among HIV-Infected Adolescents at Pediatric Department of Yopougon University Hospital, C&#244;te d’Ivoire

Abstract: Context: The consequences of non-adherence to antiretroviral therapy (ART) are harmful in terms of morbidity and mortality among HIV-infected adolescents. There is a little data in this population in West Africa, about

Cited by 3 publications

References 23 publications

Rate of virological failure and HIV-1 drug resistance among HIV-infected adolescents in routine follow-up on health facilities in Cameroon

Rate of virological failure and HIV-1 drug resistance among HIV-infected adolescents in routine follow-up on health facilities in Cameroon

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

HIV/AIDS and Discrimination in Access to and Maintenance of Employment: The Case of PLHIV&lt;sup&gt;1&lt;/sup&gt; in the Localities of Abidjan and Bouak&#233;, Ivory Coast

Contact Info

Product

Resources

About

Factors Associated with Non-Adherence to Antiretroviral Therapy among HIV-Infected Adolescents at Pediatric Department of Yopougon University Hospital, Côte d’Ivoire

HIV/AIDS and Discrimination in Access to and Maintenance of Employment: The Case of PLHIV<sup>1</sup> in the Localities of Abidjan and Bouaké, Ivory Coast