Factors associated with odour identification in older Indonesian and white Australian adults

Turana, Yuda; Lipnicki, Darren M.; Handajani, Yvonne Suzy; Sani, Tara Puspitarini; Widayanti, Josephine Retno; Suswanti, Ika; Kochan, Nicole A.; Brodaty, Henry; Sachdev, Perminder S.

doi:10.1007/s40520-019-01419-9

Cited by 4 publications

(7 citation statements)

References 57 publications

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“…Significant positive associations between measures of olfaction and performance on category and letter fluency tests have generally been found in healthy study populations (Larsson et al, 2004 ; Hedner et al, 2010 ; Goette et al, 2017 ; Choi et al, 2018 ; Yahiaoui-Doktor et al, 2019 ), in mixed clinical and control samples (Parrao et al, 2012 ; Vyhnalek et al, 2015 ; Carotenuto et al, 2019 ), in clinical populations with TBI (Sigurdardottir et al, 2010 , 2016 ; De Guise et al, 2015 ; Bakker et al, 2017 ), in older individuals or those with cognitive impairment or AD (Westervelt et al, 2005 ; Devanand et al, 2010 ; Tkalčić et al, 2011 ; Choi et al, 2018 ; Park et al, 2018 ; Churnin et al, 2019 ; Turana et al, 2020 ), old veterans (Freimer et al, 2019 ) and early psychosis (Corcoran et al, 2005 ). However, verbal fluency was not significantly associated with olfactory measures in patients with PD with or without controls (Parrao et al, 2012 ; Hanoglu et al, 2014 ) or in a sample of amyotrophic lateral sclerosis (ALS) patients and healthy participants (Parrao et al, 2012 ), in early frontal AD pathology (Lehrner et al, 2009 ) or TBI participants (Callahan and Hinkebein, 1999 ) or individuals at risk for psychosis and patients with schizophrenia (Takahashi et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding blinding of outcome assessors, only four studies described that the assessors or participants were blinded (Seidman et al, 1997 ; Purdon, 1998 ; Killgore et al, 2010 ; Park et al, 2018 ). Moreover, few of the studies did not report how many participants were excluded during the study (except Seidman et al, 1997 ; Purdon, 1998 ; Larsson et al, 2004 ; Westervelt et al, 2005 ; Rupp et al, 2006 ; Bahar-Fuchs et al, 2010 ; Hedner et al, 2010 ; Sigurdardottir et al, 2010 ; Morley et al, 2011 ; Hardy et al, 2012 ; Bettison et al, 2013 ; Devanand et al, 2015 ; Pilotto et al, 2016 ; Ward et al, 2016 ; Alosco et al, 2017 ; Bakker et al, 2017 ; Takahashi et al, 2018 ; Yahiaoui-Doktor et al, 2019 ; Turana et al, 2020 ; Cha et al, 2021 ; Gellrich et al, 2021 ) or reported an exclusion rate higher than 20% (Devanand et al, 2010 ; Churnin et al, 2019 ). More than half of the studies controlled for potential confounding variables (e.g., age, gender, education, and smoking) and performed statistical analysis within each study group (e.g., patients and control group).…”

Section: Resultsmentioning

confidence: 99%

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Olfaction and Executive Cognitive Performance: A Systematic Review

Ramaswamy

Schofield

2022

Front. Psychol.

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Objective tests of olfaction are widely available to aid in the assessment of olfaction. Their clearest role is in the characterization of olfactory changes, either reported by or suspected in a patient. There is a rapidly growing literature concerned with the association of olfactory changes with certain neuropsychiatric conditions and the use of olfactory testing to supplement conventional assessments in clinical and research practice is evolving. Neural pathways important for olfactory processing overlap extensively with pathways important for cognitive functioning, and especially those important for executive functioning, many of which are concentrated in the frontal lobes. Previous work has identified associations between performance on certain olfactory tests (most frequently olfactory identification) and executive functioning and behavioral measures (e.g. of impulsivity). More recently, similar associations have also been identified in non-clinical samples, raising new questions as to the utility of olfactory test scores as proxy measures for non-olfactory phenomena. In this systemic review, we sought to identify studies, both clinical and non-clinical, that investigated the associations of olfaction with performance on tasks sensitive to frontal lobe functioning. Our search criteria led to the identification of 70 studies published in English. We examined in detail and tabulated the data from these studies, highlighted each study's key findings, and critically evaluated these studies. We use the results of this review to reflect on some of the current and future challenges concerning the use of olfactory testing in clinical neuropsychiatric practice and research and speculate on the potential benefits of administering phonemic fluency in combination with olfactory testing to enhance its predictive value.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Olfaction and Executive Cognitive Performance: A Systematic Review

Ramaswamy

Schofield

2022

Front. Psychol.

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“…The analysis of the five domains of cognitive function showed that only the language domain was a factor influencing the olfactory function of elderly people with dementia. Several studies have reported that language ability was associated with olfactory dysfunction ( Larsson et al, 2005 ; Tonacci and Billeci, 2018 ; Turana et al, 2020 ). On the other hand, a cross-sectional study has shown that verbal intellectual abilities like analogies and synonyms was unrelated to olfactory function ( Larsson et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, although olfactory function is known to be related to the executive and memory domains of cognitive function ( Hedner et al, 2010 ). Lower language ability was reported to be associated with lower olfactory function ( Larsson et al, 2005 ; Turana et al, 2020 ), and it was found that impaired olfactory function often accompanied language impairment ( Tonacci and Billeci, 2018 ). However, there is a paucity of research on the relationship between olfactory function and the specific cognitive domains in dementia patients with cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Cognitive Function, Depression, and Olfactory Function in Elderly People With Dementia in Korea

Cha

Kim

Son

2022

Front. Aging Neurosci.

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Early detection is important for delaying or preventing cognitive impairment. Since olfactory dysfunction and depression are common symptoms of cognitive dysfunction, they may serve as measurable risk indicators. This study was designed to identify the relationship between olfaction, depression, and each domain of cognitive function in elderly dementia patients in South Korea. Study participants were 108 patients who visited the outpatient clinic between March and September 2019. More significant impairment of olfactory function was found in those with mild (7.48 ± 1.28) or moderate (7.37 ± 2.22) test scores of the Expanded Clinical Dementia Rating (CDR) scale than in those with questionable scores (20.58 ± 6.18). The language domain of cognitive function, age, and education level showed 39.2% explanatory power for olfactory function (F = 5.591, p < 0.001). It is expected that assessment of olfactory function in elderly people can lead to the early detection, diagnosis, and treatment of dementia. Furthermore, it is important for future studies to confirm the relationship between each domain of cognitive function and olfactory function according to the type of dementia and to establish criteria for screening dementia in order to utilize olfactory function as a clinical marker.

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“…There was a significant olfactory impairment among subjects with diabetes as compared with controls, but no significant association was observed between olfactory dysfunction and microvascular diabetic complications [ 17 ]. Moreover, in a population of white Australians, diabetes mellitus was among other factors (age, being male, smoking, and depression) associated with lower odour identification scores [ 18 ].…”

Section: Olfactory Dysfunction and Diabetes Mellitusmentioning

confidence: 99%

Olfactory Dysfunction: A Complication of Diabetes or a Factor That Complicates Glucose Metabolism? A Narrative Review

Gouveri¹,

Παπάνας

2021

JCM

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The present narrative review presents emerging data regarding the association between diabetes mellitus and olfactory dysfunction and discusses the role of olfactory dysfunction in glucose metabolism. We searched relevant published articles in PubMed and Google Scholar until October 2021. Main key words included “olfactory dysfunction”, “diabetes mellitus”, and “glucose metabolism”. Olfactory dysfunction has been associated with diabetes mellitus. Furthermore, it has been proposed to be a diabetic complication, given that it has been linked with microvascular complications, such as diabetic peripheral neuropathy. Interestingly, it has been suggested that olfactory dysfunction is a manifestation of central neuropathy in diabetes, a hypothesis based on the observation that diabetes, olfactory dysfunction, and cognitive decline often coexist. However, evidence is limited and inconsistent. More importantly, olfactory and endocrine systems are closely linked, and olfactory dysfunction plays a significant role in glucose metabolism and obesity. Indeed, food behaviour and energy balance are influenced by olfaction status.

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Factors associated with odour identification in older Indonesian and white Australian adults

Cited by 4 publications

References 57 publications

Olfaction and Executive Cognitive Performance: A Systematic Review

Olfaction and Executive Cognitive Performance: A Systematic Review

Associations Between Cognitive Function, Depression, and Olfactory Function in Elderly People With Dementia in Korea

Olfactory Dysfunction: A Complication of Diabetes or a Factor That Complicates Glucose Metabolism? A Narrative Review

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