Factors associated with osteoporosis among a sample of Jordanian women referred for investigation for osteoporosis

El-Heis, Mwaffaq; Al-Kamil, Eman; Kheirallah, Khalid A.; Al-Shatnawi, T N; Gharaibia, M.; Al-Mnayyis, Asma’a

doi:10.26719/2013.19.5.459

Cited by 22 publications

(22 citation statements)

References 30 publications

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“…The cumulative exposure to estrogens throughout life has a protective effect 82 Rodica Török-Oance, Melania Bala against osteoporosis [8]. Menarche occurring after the age of 14 is associated with an increased incidence of osteoporosis [9]. The age at menopause onset is a risk factor for long-term morbidity and mortality, late menopause being a risk factor for endometrial and breast cancer, and early menopause being a risk factor for osteoporosis and cardiovascular diseases; a risk that occurs because of estrogen deficiency [10].…”

Section: Resultsmentioning

confidence: 99%

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Török-Oance

Bala

2015

Asian Biomedicine

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Background: Osteoporosis is a metabolic bone disease with a risk factor of being female, particularly after the onset of menopause. Objectives: To evaluate the influence of age, anthropometric, and reproductive variables on spinal bone mineral density (BMD) in women with postmenopausal vertebral osteoporosis. Methods: The study was retrospective and included data from 171 patients with postmenopausal vertebral osteoporosis. We performed both simple and multiple regressions considering BMD in spine as the dependent variable. Coefficients of correlation (r), coefficients of determination (r

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Section: Resultsmentioning

confidence: 99%

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Török-Oance

Bala

2015

Asian Biomedicine

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“…This disease also increases the risk of fragility fractures (Chen et al, 2005;Stolk et al, 2007;El-Heis et al, 2013). Hip and vertebral fractures are also associated with high mortality in the 2 years after the event (Hiligsmann et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Osteoporotic fractures are associated with substantial morbidity and mortality and are therefore a major health care problem in post-menopausal women (Gennari et al, 2005;Stolk et al, 2007;ElHeis et al, 2013). There are several sites of potential occurrence for osteoporotic fracture including the spine, hip, distal forearm, and proximal humerus (El-Heis et al, 2013). The major determinant of bone strength and osteoporotic fracture risk is BMD (Gennari et al, 2005); BMD decrease can be accelerated by factors such as menopause and insufficient dietary calcium (Yilmaz et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…In 2010 alone, 74,000 Brazilians suffered from femur fracture (Rosa, 2015). The risk factors associated with osteoporosis include age, gender, and estrogen deficiency following menopause, and oophorectomy is correlated with a rapid reduction in bone mineral density (BMD) (El-Heis et al, 2013). Osteoporosis is a skeletal disorder characterized by a combination of low BMD and deteriorated microarchitecture, leading to an increase in bone brittleness and fracture susceptibility (Gennari et al, 2005;Stolk et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density

Gonçalves¹,

Almeida²,

Camargo-Kosugi³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In this study, we evaluated genetic factors related to the mineral density during post-menopause. We evaluated 110 women in the first 5 years post-menopause, without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 1 (ESR1) (rs9322331) were examined for the presence of polymorphisms. Clinical data were collected by anamnesis; all patients had the osseous densitometry examined using a lunar instrument to determine mineral osseous densitometry in the lumbar column (L2-L4). CYP17, COMT, and ESR1 genotyping was carried out by polymerase chain reaction with DNA collected from buccal swabs. The average age was 51.96 years. The average weights of the patients in control and osteopenia groups were 70.25 ± 12.00 and 62.45 ± 11.64, respectively (P = 0.001) and body mass index (P = 0.006; control: 29.43 ± 5.25; osteopenia: 26.72 ± 4.57). Related to CYP17 polymorphisms, 28.18% of women were TT (wild-type homozygous), 60% 15802-15810 (2015) were TC (heterozygous), and 11.82% were CC (mutated homozygous). Related to COMT polymorphisms, 53.64% of women were GG (wild-type homozygous), 37.27% were GA (heterozygous), and 9.09% were AA (mutated homozygous). Related to ESR1, 53.64% of women were CC (wildtype homozygous), 40.91% were CT (heterozygous), and 5.45% were TT (mutated homozygous). The ESR1 variant allele was significantly higher in the osteopenia group when compared with women in the normal group (P = 0.02). ESR1 may be associated with low mineral osseous densitometry, while CYP17 and COMT gene polymorphisms were not associated with mineral osseous densitometry.

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“…The prevalence of OP was notably diverse in various age groups among Iranian population [13,15], although, no patient less than 40 years had OP [15]. The prevalence of OP in Jordanian women >60 years was significantly higher compared to those <50 years (25.5% vs. 7.4%, respectively) [49]. Advanced age was also a significant predictor of OP in Moroccan postmenopausal women [32,49].…”

Section: Non-modifiable Risk Factors Modifiable Risk Factorsmentioning

confidence: 99%

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

Hammam¹

2018

Int. J. Clin. Rheumatol

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Background: Osteoporosis (OP) is defined by low bone mass and microstructural deterioration. It is an escalating public health problem due to increase life expectancy and the resulting bone fractures represent a significant burden for both the individual and the society in terms of morbidity, mortality and cost. Osteoporosis, a multifactorial disease, results from the interaction between genetic and environmental risk factors. Currently, the data available regarding OP epidemiology and predisposing risk factors differ greatly between regions and within population ethnicities. Proper estimation of the epidemiology of OP and its health related outcomes can help identity those at risk and permit prophylactic treatment before its occurrence. The main barrier towards disease prevention strategies is the impaired awareness of the disease and its risk. Enhanced understanding of the OP disease may influence personal behaviors and reduce its prevalence.Objectives: This review was undertaken to wrap-up and throw-light on the published literatures related to the epidemiology of osteoporosis in the Middle East and North Africa (MENA) region, and expose the extent of awareness in the corresponding populations. Describing and discussing key points on the current state of knowledge on these hot issues are well thought-out.Conclusion: Osteoporosis prevalence is variable among MENA populations. Limited reports regarding the established prevalence of osteoporotic fractures among those populations and therefore, lack of guidelines for prevention and management were noticed. In order to improve bone health, preventive measures against OP should be considered. Increase OP awareness and preventive practices in the societies as part of the prophylactic strategy need to be initiated.

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Factors associated with osteoporosis among a sample of Jordanian women referred for investigation for osteoporosis

Cited by 22 publications

References 30 publications

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

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