Factors associated with physical activity in patients with osteoarthritis of the hip or knee: a systematic review

Veenhof, Cindy; Huisman, P.A.; Barten, Di-Janne; Takken, Tim; Pisters, Martijn F.

doi:10.1016/j.joca.2011.10.006

Cited by 93 publications

(96 citation statements)

References 35 publications

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“…2) and is often influenced by psychosocial conditions. Factors underlying OA such as psychosocial factors, mood and coping can influence pain severity, and should be considered in the light of age, gender, anatomical site, body mass index (BMI), comorbidities, educational level, and other psychological factors (75,76).…”

Section: N Constitutional and Bio-psychosocial Factors Of Osteoarthrimentioning

confidence: 99%

The sources of pain in osteoarthritis: a pathophysiological review

2014

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summaryThe pain of osteoarthritis (OA) has multifaceted etiologies within and outside the joint. It is believed to be driven by both nociceptive and neuropathic mechanisms, as well as abnormal excitability in the pain pathways of the peripheral and central nervous system. Inflammation in the joint triggers a cascade of events that leads to peripheral sensitization, increased sensitivity of nociceptive primary afferent neurons, and hyperexcitability of the nociceptive neurons in the central nervous system. Pain receptors have been found in the synovium, ligaments, capsule, subchondral bone and surrounding tissues, with the exception of articular cartilage. The bone-related causes of pain in OA include subchondral microfractures, bone stretching with elevation of the periosteum due to osteophyte growth, bone remodeling and repair, bone marrow lesions, and bone angina caused by decreased blood flow and increased intra-osseous pressure. Central factors alter pain processing by setting the gain in such a way that, when a peripheral input is present, it is processed against a background of central factors that can enhance or diminish the experience of pain. As a complex phenomenon with a strong subjective component, pain can also be influenced by the nature of the underlying disease, personal predisposition (biological and psychological), and environmental and psychosocial factors. This review examines the current literature regarding the sources and mechanisms of pain in OA.

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Section: N Constitutional and Bio-psychosocial Factors Of Osteoarthrimentioning

confidence: 99%

The sources of pain in osteoarthritis: a pathophysiological review

2014

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“…A high BMI is associated with limited physical performance and functional mobility in elderly persons or patients with OA (8)(9)(10)(11), and a high preoperative BMI is associated with post-TKR physical disability in obese patients with OA (12). However, the relationship between obesity and post-TKR outcome has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index and Functional Mobility Outcome Following Early Rehabilitation After a Total Knee Replacement: A Retrospective Study in Taiwan

Liao

Huang

et al. 2015

Arthritis Care & Research

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ObjectiveObesity is associated with an increased risk of osteoarthritis, and the incidence of obese patients requiring a total knee replacement (TKR) has increased in recent years. A high body mass index (BMI) may influence post‐TKR rehabilitation outcomes. We investigated the effects of obesity on functional mobility outcomes following post‐TKR rehabilitation in Asian patients whose BMIs were not as high as those reported in similar studies performed in non‐Asian countries.MethodsA total of 113 patients were categorized as normal weight (n = 23), overweight (n = 32), class I obese (n = 31), or class II/III obese (n = 27). Patients were retrospectively followed up for 6 months after undergoing TKR followed by 2 months of active rehabilitation. Outcome measures were recorded at baseline and at the 2‐month and 6‐month followup assessments and included the Western Ontario and McMaster Universities Osteoarthritis Index and the following tests: functional reach, single‐leg stance, ten‐meter walk, timed up and go, chair rise, and stair climbing.ResultsA 4 × 3 (group × time) repeated‐measures analysis of variance showed significant improvement in all of the outcome measures for all of the BMI groups at the 2‐month and 6‐month followup assessments (P < 0.05 for all). No significant intergroup differences at the 2‐month and 6‐month followup assessments were observed for any of the mobility measures except the functional reach and single‐leg stance (P < 0.05).ConclusionPatients with class II/III obesity benefit from early post‐TKR outpatient rehabilitation and respond as well as patients with lower BMIs.

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“…Older age, female sex, lower education level, higher body mass index (BMI), comorbidity, pain, depressed mood, and low vitality have been associated with avoidance of activities or physical inactivity in persons with knee OA (5,17). However, the evidence for these associations is conflicting due to differences in methodologic design (17). Furthermore, most studies on this relationship addressed persons with established OA.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, most studies on this relationship addressed persons with established OA. Longitudinal studies on predictors of avoidance of activities are lacking (17).…”

Section: Introductionmentioning

confidence: 99%

Predictors and Outcome of Pain‐Related Avoidance of Activities in Persons With Early Symptomatic Knee Osteoarthritis: A Five‐Year Followup Study

Holla

Leeden

Knol

et al. 2014

Arthritis Care & Research

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Objective. It has been hypothesized that pain and low vitality lead to an increase in avoidance of activities in persons with early symptomatic knee osteoarthritis (OA), and that avoidance of activities leads to an increase in activity limitations. The present study aimed to evaluate these hypotheses. Methods. Baseline, 2-year, and 5-year followup data of 828 participants from the Cohort Hip and Cohort Knee Study with early symptomatic knee OA were used. Autoregressive generalized estimating equations and linear regression models were used to analyze the longitudinal and cross-sectional associations between self-reported knee pain, vitality, painrelated avoidance of activities, and activity limitations. The models were adjusted for the covariates age, sex, education level, body mass index, comorbidity, radiographic severity, and hip pain. Results. In longitudinal analyses, knee pain and vitality predicted a subsequent increase in avoidance of activities. Pain-related avoidance of activities predicted a subsequent increase in activity limitations; however, this relationship lost statistical significance (P ‫؍‬ 0.089) after adjustment for covariates. Cross-sectional analyses showed strong relationships between knee pain, low vitality, pain-related avoidance of activities, and activity limitations at all time points. Conclusions. In persons with early symptomatic knee OA, knee pain and low vitality lead to a subsequent increase in avoidance of activities. Pain-related avoidance of activities is related to activity limitations at inception of symptoms, but also years later. Therefore, it can be recommended to monitor and target avoidance of activities at various stages of the disease.

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Factors associated with physical activity in patients with osteoarthritis of the hip or knee: a systematic review

Cited by 93 publications

References 35 publications

The sources of pain in osteoarthritis: a pathophysiological review

The sources of pain in osteoarthritis: a pathophysiological review

Body Mass Index and Functional Mobility Outcome Following Early Rehabilitation After a Total Knee Replacement: A Retrospective Study in Taiwan

Predictors and Outcome of Pain‐Related Avoidance of Activities in Persons With Early Symptomatic Knee Osteoarthritis: A Five‐Year Followup Study

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