2022
DOI: 10.1016/s2665-9913(22)00065-0
|View full text |Cite
|
Sign up to set email alerts
|

Factors associated with poor antibody response to third-dose SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
12
1
5

Year Published

2022
2022
2023
2023

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 9 publications
(18 citation statements)
references
References 10 publications
0
12
1
5
Order By: Relevance
“…Of note, the percentage of non-responders or suboptimal-responders ASD patients who experienced an increase of serum NAb titers after the booster dose is extremely variable in the previous reports (from 16.3% to 92%) [ [20] , [21] , [22] , [23] , [24] , [25] , [26] ]. Thus, it is possible to hypothesize that the reported discrepancies in the improvement of booster-related immunogenicity may reflect a variable contribution of several factors; in particular, the differences among various patients’ series investigated in ASD subtype composition and/or in the treatments employed in the peri-vaccination period.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Of note, the percentage of non-responders or suboptimal-responders ASD patients who experienced an increase of serum NAb titers after the booster dose is extremely variable in the previous reports (from 16.3% to 92%) [ [20] , [21] , [22] , [23] , [24] , [25] , [26] ]. Thus, it is possible to hypothesize that the reported discrepancies in the improvement of booster-related immunogenicity may reflect a variable contribution of several factors; in particular, the differences among various patients’ series investigated in ASD subtype composition and/or in the treatments employed in the peri-vaccination period.…”
Section: Discussionmentioning
confidence: 99%
“…A number of reports, generally on small patients series, often focusing on single autoimmune disorders, underlined effective seroconversion produced by the booster dose of vaccine [ 20 , 21 , [24] , [25] , [26] ], as well as the weak response to the booster vaccine in ASD patients previously treated with RTX or MMF [ 21 , 22 , [24] , [25] , [26] ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…While we observed significantly diminished antibody titers in BS patients, especially in those treated with anti-TNF agents compared to healthy individuals among Cor-onaVac recipients, no such difference was detected in the BioNTech group. We and others have previously shown that immunocompromised patients often fail to show an adequate response to SARS-CoV-2 vaccines, as indicated by lower protective immune response rates compared with healthy individuals [5][6][7][8][24][25][26][27][28][29][30][31][32][33][34][35][36]. Almost all DMARDs including mycophenolate mofetil, methotrexate, rituximab, abatacept and glucocorticoids have been shown to blunt humoral responses [7,[24][25][26][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…With regard to anti-SARS-CoV-2 vaccination, prime immunization may be especially impaired by age ≥60 years, prednisone, and some specific immunosuppressive and biological drugs [ 1 , 7 , 8 ], reinforcing the need for additional doses. Both homologous and heterologous third dose of anti-SARS-CoV-2 vaccination have been associated with robust humoral response in this population [ 9 , 10 ]. Furthermore, a recent small sized study of a fourth anti-SARS-CoV-2 dose demonstrated enhanced immunogenicity in ARD patients, although still impaired by MMF [ 4 ].…”
Section: Introductionmentioning
confidence: 99%