Factors associated with potentially harmful drug–drug interactions in older Korean people: A population‐based study

Yoon, Seok Jun; Kim, Jong Sung; Jung, Jin‐Gyu; Ahn, Soon-Ki; Song, Young-Su; Bae, Nam-Kyou

doi:10.1111/ggi.13640

Geriatrics Gerontology Int

2019

DOI: 10.1111/ggi.13640

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Factors associated with potentially harmful drug–drug interactions in older Korean people: A population‐based study

Seok Jun Yoon

Jong Sung Kim

Jin‐Gyu Jung

et al.

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Cited by 3 publications

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“…A study by Yoon et al investigated the actual occurrence frequency of the items listed as PHDI in the Beers criteria in the Asian population . In addition, the background factors that are likely to cause PHDI were assessed.…”

mentioning

confidence: 99%

Transdisciplinary approach for potentially harmful drug–drug interaction detection as a part of a comprehensive medication review and geriatric assessment

Tomita

Mizokami

Kisara

et al. 2019

Geriatrics Gerontology Int

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mentioning

confidence: 99%

Transdisciplinary approach for potentially harmful drug–drug interaction detection as a part of a comprehensive medication review and geriatric assessment

Tomita

Mizokami

Kisara

et al. 2019

Geriatrics Gerontology Int

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Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study

Başpınar

Basat

2020

Pak J Med Sci

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Objectives: To assess inappropriate analgesic use (IAU) by comparison of STOPP/START Version-2 and Beers 2019 criteria. Methods: This is a cross-sectional study of 331 elderly patients admitted to family medicine clinics at a tertiary hospital between February and July 2018. Data were collected from face-to-face surveys, including informed patient consent and electronic drug monitoring databases. Results: The presence of IAU by STOPP version2 was higher than the Beers criteria (19.6%, 14.5%, respectively; P<0.04; Z= –2.5) with a moderate agreement (Kappa= 0.458). The number of drugs and pain score were predictors of IAU. The most commonly caused IAU was diclofenac, although naproxen was the most used analgesic. Almost 39% of diclofenac use, 18.5% of naproxen use, and 33% of etodolac use were IAU. Most commonly, IAU reasons were; (i) NSAID use in hearth failure (Beers) (ii) NSAID use with an antiplatelet agent(s) without PPI (STOPP). Conclusions: The difference between criteria in terms of IAU was significant in favor of STOPP V2. doi: https://doi.org/10.12669/pjms.36.5.2331 How to cite this:Baspınar MM, Basat O. Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.2331 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

Zhao

Liu²,

Feng³

et al. 2022

Front. Pharmacol.

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Introduction: Polypharmacy are commonly observed among older adults with cardiovascular disease. However, multiple medications lead to increased risk of drug-drug interactions (DDIs). Therefore, identification and prevention actions related to harmful DDIs are expected in older adults. The study aimed to describe the prevalence of potential DDIs (pDDIs) in discharge prescriptions among older adults with chronic coronary syndrome (CCS).Methods: A single-center cross-sectional study was performed in a tertiary public hospital in Beijing, China. CCS patients aged 65 years and above who were admitted to cardiology wards over a 3-month period and alive at discharge were included. Electronic medical records and discharge prescriptions were reviewed. pDDIs were evaluated through the Lexi-Interact online.Results: pDDIs were identified in 72.9% of the 402 individuals (n = 293). A total of 864 pDDIs were obtained. 72.1% of patients were found with C DDIs (n = 290) and 20.3% were categorized in D and X DDIs (n = 82). The only X DDI was between cyclosporine and atorvastatin. Under category D, glycemia alterations within antidiabetics and increased chances of bleeding with antithrombotic were the most common. Concomitant use of clopidogrel and calcium channel blockers was a frequent situation within category C, followed by synergic blood pressure lowering agents and increased rosuvastatin concentration induced by clopidogrel.Conclusion: DDIs exposure was common in older CCS. DDIs screening tools should be introduced to alert potential adverse effects. Prescribers need to rigorously review or modulate therapies to prevent DDI-related adverse outcomes. Clinical pharmacists should be more involved in complex drug regimen management.

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Factors associated with potentially harmful drug–drug interactions in older Korean people: A population‐based study

Cited by 3 publications

References 8 publications

Transdisciplinary approach for potentially harmful drug–drug interaction detection as a part of a comprehensive medication review and geriatric assessment

Transdisciplinary approach for potentially harmful drug–drug interaction detection as a part of a comprehensive medication review and geriatric assessment

Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study

Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

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