Factors associated with professional support access among a prospective cohort of methamphetamine users

Quinn, Brendan; Stoové, Mark; Dietze, Paul

doi:10.1016/j.jsat.2013.02.003

Cited by 21 publications

(18 citation statements)

References 43 publications

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“…STI and HIV prevention initiatives targeting heterosexual people who use methamphetamine are currently less well developed than those targeting MSM, and are likely to be challenged by lack of methamphetamine‐specific treatment options and the relatively low levels of contact that people who use methamphetamine have with health services . Sexual health messages could be delivered to people who inject methamphetamine in tandem with blood‐borne virus prevention efforts (e.g.…”

Section: Discussionmentioning

confidence: 99%

The relationship between methamphetamine use and heterosexual behaviour: evidence from a prospective longitudinal study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

The relationship between methamphetamine use and heterosexual behaviour: evidence from a prospective longitudinal study

et al. 2018

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“…Our estimate of a minimal clinically meaningful reduction in use is based on outcomes for outpatient counselling derived from MATES: 11.2 (8.8) days per month to 3.5 (6.9) days per month at 12 weeks. Our estimate of 20% attrition is based on our previous research [42, 50, 51]. No interim analyses are planned.…”

Section: Methodsmentioning

confidence: 99%

A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine (“ice”) dependence

McKetin

Dean

Turner

et al. 2019

Trials

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Background There are currently no approved pharmacotherapies for managing methamphetamine dependence. N -acetylcysteine (NAC) has been found to reduce the craving for methamphetamine and other drugs, but its effect on methamphetamine use and other clinically related endpoints are uncertain. The N-ICE trial is evaluating the safety and efficacy of NAC as a take-home pharmacotherapy for methamphetamine dependence. Methods/design This is a two-arm parallel double-blind placebo-controlled three-site randomised trial (ratio 1:1) using permuted block randomisation, with variable block sizes. It is stratified by site, sex and whether the methamphetamine is injected or not. Participants ( N = 180; 60 per site) need to be dependent on methamphetamine, interested in reducing their methamphetamine use and not currently receiving treatment for substance use disorders. The trial is being conducted in outpatient settings in Melbourne, Geelong and Wollongong, Australia. Participants will receive either 2400 mg oral NAC or a matched placebo, delivered as a take-home medication for 12 weeks. Two 600 mg capsules are self-administered in the morning and two more in the evening. Adherence is being monitored using eCAP™ medication bottle lids, which record the date and time of each occasion the bottle is opened. The primary outcome is methamphetamine use during the 12-week trial medication period, measured as (a) days of use, assessed using the timeline followback, and (b) methamphetamine-positive saliva tests, taken weekly. Secondary measures include weekly assessment of methamphetamine craving, severity of methamphetamine dependence, methamphetamine withdrawal symptoms and psychiatric symptoms (depression, suicidality, psychotic symptoms and hostility). Adverse events are monitored at each weekly assessment. Tolerability is assessed using the Treatment Satisfaction Questionnaire for Medication. Discussion The N-ICE trial is the first clinical trial to assess whether NAC can reduce methamphetamine use. This trial will improve our understanding of the potential utility of NAC in managing methamphetamine dependence and clinically related outcomes. If found to be effective, take-home NAC could be a potentially scalable and affordable pharmacotherapy option for treating methamphetamine dependence. Trial registration Australian and New Zealand Clinical Trials Registry, ACTRN12618000366257 . Registered on 29 May 2018. Electronic supplementary material The online version of this article (10.1186/s13063-019-3450-0) contains supplementary material, which is available to authorized users.

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“…Participants were asked whether they had sought help from family and/or friends to reduce/cease methamphetamine use in the past 30 days. A second measure asked about help from family and/or friends in the past 12 months [77].

Perceived need defined as an individual’s judgments about whether they require substance use services.

…”

Section: Resultsmentioning

confidence: 99%

The role of consumer perspectives in estimating population need for substance use services: a scoping review

Hyshka

Karekezi

Tan

et al. 2017

BMC Health Serv Res

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BackgroundA growing body of research assesses population need for substance use services. However, the extent to which survey research incorporates expert versus consumer perspectives on service need is unknown. We conducted a large, international review to (1) describe extant research on population need for substance use services, and the extent to which it incorporates expert and consumer perspectives on service need, (2) critically assess methodological and measurement approaches used to study consumer-defined need, and (3) examine the potential for existing research that prioritizes consumer perspectives to inform substance use service system planning.MethodsSystematic searches of seven databases identified 1930 peer-reviewed articles addressing population need for substance use services between January 1980 and May 2015. Empirical studies (n = 1887) were categorized according to source(s) of data used to derive population estimates of service need (administrative records, biological samples, qualitative data, and/or quantitative surveys). Quantitative survey studies (n = 1594) were categorized as to whether service need was assessed from an expert and/or consumer perspective; studies employing consumer-defined need measures (n = 217) received further in-depth quantitative coding to describe study designs and measurement strategies.ResultsAlmost all survey studies (96%; n = 1534) used diagnostically-oriented measures derived from an expert perspective to assess service need. Of the small number (14%, n = 217) of survey studies that assessed consumer’s perspectives, most (77%) measured perceived need for generic services (i.e. ‘treatment’), with fewer (42%) examining self-assessed barriers to service use, or informal help-seeking from family and friends (10%). Unstandardized measures were commonly used, and very little research was longitudinal or tested hypotheses. Only one study used a consumer-defined need measure to estimate required service system capacity.ConclusionsRhetorical calls for including consumer perspectives in substance use service system planning are belied by the empirical literature, which is dominated by expert-driven approaches to measuring population need. Studies addressing consumer-defined need for substance use services are conceptually underdeveloped, and exhibit methodological and measurement weaknesses. Further scholarship is needed to integrate multidisciplinary perspectives in this literature, and fully realize the promise of incorporating consumer perspectives into substance use service system planning.Electronic supplementary materialThe online version of this article (doi:10.1186/s12913-017-2153-z) contains supplementary material, which is available to authorized users.

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Factors associated with professional support access among a prospective cohort of methamphetamine users

Cited by 21 publications

References 43 publications

The relationship between methamphetamine use and heterosexual behaviour: evidence from a prospective longitudinal study

The relationship between methamphetamine use and heterosexual behaviour: evidence from a prospective longitudinal study

A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine (“ice”) dependence

The role of consumer perspectives in estimating population need for substance use services: a scoping review

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