Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study

Lee, Dominic T.S.; Wing, Yun Kwok; Leung, Hoi Yan; Sung, Joseph J.Y.; Ng, Yuen Keng; Yiu, G.-C.; Chen, Ronald Y. L.; Chiu, Helen F. K.

doi:10.1086/424016

Cited by 122 publications

(122 citation statements)

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“…The results are not surprising as, in addition to the physical impairment, the long period of isolation and extreme uncertainty during the SARS illness had created enormous psychological stress [150] and mood disturbances [151]. Furthermore, steroid toxicity, personal vulnerability and psychosocial stressors might have contributed to the development of psychosis in some patients [152]. Longer term follow-up is needed to assess if these deficits are persistent.…”

Section: Long-term Outcomementioning

confidence: 99%

SARS: clinical presentation, transmission, pathogenesis and treatment options

2006

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SARS (severe acute respiratory syndrome) appeared as the first emerging infectious disease of this century. It is fortunate that the culprit virus can be grown without much difficulty from a commonly used cell line, allowing an unlimited supply of isolates for further molecular studies and leading to the development of sensitive diagnostic assays. How the virus has successfully jumped the species barrier is still a mystery. The superspreading events that occurred within hospital, hotel and high-density housing estate opens a new chapter in the mechanisms and routes of virus transmission. The old practice of quarantine proved to be still useful in controlling the global outbreak. Despite all the available sophisticated tests, alertness with early recognition by healthcare workers and prompt isolation of suspected cases is still the most important step for containing the spread of the infection. Although the rapidly evolving outbreak did not allow the conducting of systematic clinical trails to evaluate treatment options, the accumulated experience on managing SARS patients will improve the clinical outcome should SARS return. Although SARS led to more than 700 deaths worldwide, the lessons learnt have prepared healthcare systems worldwide to face future emerging and re-emerging infections.

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Section: Long-term Outcomementioning

confidence: 99%

SARS: clinical presentation, transmission, pathogenesis and treatment options

2006

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“…Brown and associates [2] and Lee and associates [17] report higher rates of psychiatric episodes where there is family history of psychiatric illness. Chau and Mok [3] describe a history of anxiety disorders as a predictive factor for corticosteroid psychosis and Brown and associates [2] describe posttraumatic stress disorder as increasing the likelihood of mood disturbance during corticosteroid treatment.…”

Section: Introductionmentioning

confidence: 99%

“I was never like that”: Australian findings on the psychological and psychiatric sequelae of corticosteroids in haematology treatments

McGrath

Patton

James

2008

Support Care Cancer

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The findings provide evidence that emotional disturbances associated with corticosteroid use in haematology are a direct result of the drugs used and not a symptom of the individual's prior emotional health. Recommendations are given which have important implications for the management, support and education of patients and their families in relation to the potential emotional side effects from steroid administration and withdrawal.

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“…1 The first was a case-control study of SARS patients with (n=15) and without (n=30) SARS-related psychosis; all were given corticosteroid treatment, but those who developed psychosis were given a higher cumulative dose than those who did not (10 975 mg hydrocortisone equivalent vs 6780 mg; p=0·017). 6 The second was a randomised controlled trial of 16 patients with SARS who were not critically ill; the nine patients who were given hydrocortisone (mean 4·8 days [95% CI 4·1-5·5] since fever onset) had greater viraemia in the second and third weeks after infection than those who were given 0·9% saline control. 5 The remaining two studies reported diabetes and avascular necrosis as complications associated with corticosteroid treatment.…”

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confidence: 99%