Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules

Wu, Weida; Peng, Jianyang; Gao, Hongbin; Lin, Yongwen; Lin, Qunying; Zhicheng, Weng

doi:10.1177/15330338221094429

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…[ 6 ] Thus, early detection, diagnosis , and treatment of GGN are associated with good prognosis and patient outcomes. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

A metabolomics study on carcinogenesis of ground-glass nodules

Zhang,

Tong,

Chen

et al. 2024

Cytojournal

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Objective: This study aimed to identify differential metabolites and key metabolic pathways between lung adenocarcinoma (LUAD) tissues and normal lung (NL) tissues using metabolomics techniques, to discover potential biomarkers for the early diagnosis of lung cancer. Material and Methods: Forty-five patients with primary ground-glass nodules (GGN) identified on computed tomography imaging and who were willing to undergo surgery at Shanghai General Hospital from December 2021 to December 2022 were recruited to the study. All participants underwent video thoracoscopy surgery with segmental or wedge resection of the lung. Tissue samples for pathological examination were collected from the site of ground-glass nodules (GGN) lesion and 3 cm away from the lesion (NL). The pathology results were 35 lung adenocarcinoma (LUAD) cases (13 invasive adenocarcinoma, 14 minimally invasive adenocarcinoma, and eight adenocarcinoma in situ), 10 benign samples, and 45 NL tissues. For the untargeted metabolomics technique, 25 LUAD samples were assigned as the case group and 30 NL tissues as the control group. For the targeted metabolomics technique, ten LUAD samples were assigned as the case group and 15 NL tissues as the control group. Samples were analyzed by untargeted and targeted metabolomics, with liquid chromatography-tandem mass spectrometry detection used as part of the experimental procedure. Results: Untargeted metabolomics revealed 164 differential metabolites between the case and control groups, comprising 110 up regulations and 54 down regulations. The main metabolic differences found by the untargeted method were organic acids and their derivatives. Targeted metabolomics revealed 77 differential metabolites between the case and control groups, comprising 69 up regulations and eight down regulations. The main metabolic changes found by the targeted method were fatty acids, amino acids, and organic acids. The levels of organic acids such as lactic acid, fumaric acid, and malic acid were significantly increased in LUAD tissue compared to NL. Specifically, an increased level of L-lactic acid was found by both untargeted (variable importance in projection [VIP] = 1.332, fold-change [FC] = 1.678, q = 0.000) and targeted metabolomics (VIP = 1.240, FC = 1.451, q = 0.043). Targeted metabolomics also revealed increased levels of fumaric acid (VIP = 1.481, FC = 1.764, q = 0.106) and L-malic acid (VIP = 1.376, FC = 1.562, q = 0.012). Most of the 20 differential fatty acids identified were downregulated, including dodecanoic acid (VIP = 1.416, FC = 0.378, q = 0.043) and tridecane acid (VIP = 0.880, FC = 0.780, q = 0.106). Furthermore, increased levels of differential amino acids were found in LUAD samples. Conclusion: Lung cancer is a complex and heterogeneous disease with diverse genetic alterations. The study of metabolic profiles is a promising research field in this cancer type. Targeted and untargeted metabolomics revealed significant differences in metabolites between LUAD and NL tissues, including elevated levels of organic acids, decreased levels of fatty acids, and increased levels of amino acids. These metabolic features provide valuable insights into LUAD pathogenesis and can potentially serve as biomarkers for prognosis and therapy response.

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“…[ 6 ] Thus, early detection, diagnosis , and treatment of GGN are associated with good prognosis and patient outcomes. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

A metabolomics study on carcinogenesis of ground-glass nodules

Zhang,

Tong,

Chen

et al. 2024

Cytojournal

View full text Add to dashboard Cite

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Stereotactic body radiation therapy and thermal ablation for treatment of NSCLC: A systematic literature review and meta-analysis

Laeseke

Ferko

et al. 2023

Lung Cancer

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Thermal ablation for local control of lung metastases and its effect on pulmonary function

Kim,

LeMaster,

Suh

2024

AJIR

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Image-guided thermal ablation in the lung has consistently demonstrated preservation of lung function without permanent decline following treatment compared to other local treatment options, specifically surgical intervention or stereotactic radiation therapy. Here, we report a case of a 68-year-old female with mesonephric adenocarcinoma of the uterus metastatic to the lung, treated with primarily thermal ablation to manage her lung tumor burden. The patient underwent a hysterectomy and wedge resection of the left lower lobe in addition to first-line chemotherapy. To reduce the total lung tumor burden, in the absence of other more effective therapies and to strategically eradicate ultra-central lung tumors, the patient underwent multiple ablative therapies. In total, she underwent 45 ablation sessions, of which 42 were cryoablation with the rest conducted with microwave ablation, two stereotactic body radiation therapies, and one brachytherapy for 75 lung metastases. Pulmonary function tests were conducted before the start of serial ablation treatments and measured again after 32 ablation sessions which revealed minimal change in pulmonary function parameters while maintaining adequate functional status. We highlight the potential benefit of ablative therapies regarding pulmonary function compared to other local treatment options for metastatic lung cancer.

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Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules

Cited by 4 publications

References 19 publications

A metabolomics study on carcinogenesis of ground-glass nodules

A metabolomics study on carcinogenesis of ground-glass nodules

Stereotactic body radiation therapy and thermal ablation for treatment of NSCLC: A systematic literature review and meta-analysis

Thermal ablation for local control of lung metastases and its effect on pulmonary function

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