Objective:
To evaluate the association between novel pre-and post-operative biomarker levels and 30-day unplanned readmission or mortality after pediatric congenital heart surgery.
Methods:
Children aged 18 years or younger undergoing congenital heart surgery (n=162) , at Johns Hopkins Hospital from 2010–2014 were enrolled in the prospective cohort. Collected novel pre-and postoperative biomarkers include: soluble suppression of tumorgenicity 2, Galectin-3, N-terminal prohormone of brain natriuretic peptide and glial fibrillary acidic protein. A model based on clinical variables from the Society of Thoracic Surgery database was developed and evaluated against two augmented models.
Results:
Unplanned readmission or mortality within 30-days of cardiac surgery occurred among 21 (13%) children. The clinical model augmented with pre-operative biomarkers demonstrated a statistically significant improvement over the clinical model alone with an receiver operating characteristics curve to 0.754 (95% CI:0.65 – 0.86) compared to 0.617 (95% CI: 0.47 – 0.76; p-value 0.012). The clinical model augmented with pre-and postoperative biomarkers demonstrated a significant improvement over the clinical model alone, with an receiver operating characteristics curve of 0.802 (95% CI: 0.72 – 0.89; p-value 0.003).
Conclusions:
Novel biomarkers add significant predictive value when assessing the likelihood of unplanned readmission or mortality after pediatric congenital heart surgery. Further exploration of the utility of these novel biomarkers during the peri- or post-operative period to identify early risk of mortality or readmission will aid in determining the clinical utility and application of these biomarkers into routine risk assessment.