Factors associated with readmission to the hospital within 30 days in patients with inflammatory bowel disease

Micic, Dejan; Gaetano, John N.; Rubin, Jonah; Cohen, Russell D.; Sakuraba, Atsushi; Rubin, David T.; Pekow, Joel

doi:10.1371/journal.pone.0182900

Cited by 45 publications

(52 citation statements)

References 30 publications

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“…The same criteria for Ulcerative Colitis disease cohort have been used in prior studies, albeit with different clinical outcomes. [12] Cannabis use was defined by ICD-9-CM codes 304.3, 304.3x, and 305.2x: as either mild (nondependent use) or moderate/severe (dependent use), which has also been used in previous studies. [13] To minimize potential confounders, we excluded patients with a diagnosis of abuse of other substances including opioid, amphetamine, psychostimulants, cocaine, sedative, antidepressant, and hallucinogens while retaining patients that use tobacco and alcohol.…”

Section: Methodsmentioning

confidence: 99%

Association between cannabis use and complications related to ulcerative colitis in hospitalized patients

et al. 2019

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Ulcerative colitis (UC) is a chronic inflammatory process that is occasionally associated with complications that cause significant morbidity and mortality. Studies in experimental animal models have demonstrated a beneficial effect of cannabis on intestinal inflammation. It is however unknown if this corresponds to fewer complications for patients with Ulcerative Colitis. We aimed to compare the prevalence of UC related complications and certain key clinical endpoints among cannabis users and nonusers hospitalized with a primary diagnosis of UC, or primary diagnosis of a UC-related complication with a secondary diagnosis of UC. Using data from the Healthcare Cost and Utilization Project-National Inpatient Sample (NIS) during 2010–2014, a total of 298 cannabis users with UC were compared to a propensity score matched group of nonusers with UC. We evaluated several UC-related complications and clinical endpoints. Within our matched cohort, prevalence of partial or total colectomy was lower in cannabis users compared to nonusers (4.4% vs 9.7%, P = .010) and there was a trend toward a lower prevalence of bowel obstruction (6.4% vs 10.7%, P = .057). Cannabis users had shorter hospital length-of-stay (4.5 vs 5.7 days P < .007) compared to their nonuser counterparts. Cannabis use may mitigate some of the well described complications of UC among hospitalized patients. Our findings need further evaluation, ideally through more rigorous clinical trials.

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Section: Methodsmentioning

confidence: 99%

Association between cannabis use and complications related to ulcerative colitis in hospitalized patients

et al. 2019

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“…18,20–24,26–31,33–42 The median follow-up time was 12 months [IQR 10–22.9], and follow-up data were extracted from medical records or insurance data in 38.6% of associations, 16,17,19,25,27,32,42 assessed during hospital visits in 33.1% 18,21,23,24,27,29–31,33,34,36–38 and self-reported in 28.6%. 20,22,25,26,28,35,39–41 Twelve [44.4%] studies included both CD and UC, 16,17,19,20,22,28,32–35,40,41 and two of these included IBD-U or IC as well. 33,40 Ten studies included only CD patients, 18,23–27,31,36,38,42 and five studies only UC.…”

Section: Resultsmentioning

confidence: 99%

“…An ‘association’ therefore implies an investigated, but not necessarily a statistically significant, relationship. Somatic and functional assessment were measured in 39 associations [23.1%], 27,32,42 mental in 117 associations [69.2%], 16–22,24–26,28–41 and social in 13 associations [7.7%]. 16,20,22,23,36 None of the studies used a measurement of functional performance, cognitive status, or frailty [Figure 2].…”

Section: Resultsmentioning

confidence: 99%

Systematic Review: Components of a Comprehensive Geriatric Assessment in Inflammatory Bowel Disease—A Potentially Promising but Often Neglected Risk Stratification

Asscher

Lee-Kong

Kort

et al. 2019

Journal of Crohn's and Colitis

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BackgroundThe population of older patients with inflammatory bowel disease [IBD] is increasing. Patient age does not fully account for poor outcomes and its clinical utility for risk stratification is limited. Comprehensive geriatric assessment [CGA], comprising a somatic, functional, mental, and social assessment or frailty, could be a predictor tool.AimsTo systematically review literature on the kind of components of a CGA being used in adult IBD patients and the association of these components with adverse health outcomes.MethodsAn electronic literature search was performed on January 16, 2018, using PubMed, Embase, Web of Science, the Cochrane Library, CENTRAL, Emcare, and PsycINFO. Longitudinal studies relating somatic, functional, mental, and social assessment or frailty to adverse health outcomes during follow-up in IBD patients were included. The Newcastle-Ottawa scale was used to assess individual study quality.ResultsOf 4080 identified citations, 27 studies were included, reporting 169 associations. Median sample size was 108 patients (interquartile range [IQR] 60–704). No studies performed subgroup analyses on older patients, and the highest mean age reported was 52.7 years. Somatic and functional assessments were used in three studies, mental in 24, and social in five. No study assessed cognitive status, functional performance, or frailty. In 62 associations [36.7%], components of a CGA were significantly associated with adverse health outcome measurements.ConclusionsComponents of a CGA were associated with adverse health outcomes in IBD patients, but older patients were under-represented. More studies among older patients with IBD are warranted to further establish the clinical impact of a CGA.

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“…The results showed that current smokers were more likely to be readmitted within 30 days and one year of discharge compared to never smokers ( Table 2 , Table 3 ). Researchers studying 30-day readmission of patients with inflammatory bowel disease also found smoking as one of the comorbidities associated with increased risk of readmissions within 30 days ( Micic et al, 2017 ). Other studies in the general population observed that smoking was a risk factor for hospitalization and readmission with some research reporting that patients who received tobacco dependence treatment had lower odds of readmission at 30 days postdischarge ( Cartmell et al, 2018 ; El Solh, Brewer, Okada, Bashir, & Gough, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Association between smoking, and hospital readmission among inpatients with psychiatric illness at an academic inpatient psychiatric facility, 2000–2015

Kagabo

Kim

Zubieta

et al. 2019

Addictive Behaviors Reports

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Introduction Smoking rates are up to 2–4 times higher among individuals with mental illness. Hospital readmissions for patients with psychiatric illness within a year of discharge are also high, and there is limited evidence of associations between smoking and these readmissions. Methods This study was a secondary data analysis using clinical data of psychiatric inpatients with initial admissions between the years 2000 and 2015. Following a descriptive analysis, logistic regression models were fitted to explore relationships between smoking and psychiatric hospital readmission within 30 days and a year of discharge. Results A total of 5439 patients with average age of 30.18 ± 15.97 were identified. Of this number, 47.0% were current smokers and 53.0% were never smokers. Within 30 days of discharge, 11% of the current smokers were readmitted compared to 9% of never smokers. The primary diagnoses with highest proportion of smokers were, opioid or substance use disorders (80.0%), schizophrenia (70.7%), alcohol dependence (68.2%), and bipolar disorders (50.8%). About 31% of current smokers were readmitted within one year of discharge compared to 26% of never smokers. Adjusted odds ratios for readmission within 1-year of discharge were, bipolar disorders (1.41, p = 0.01), schizophrenia (2.33, p < 0.001), and opioid/substance dependence (1.55, p = 0.01). Conclusion Significant relationships exist between smoking and readmission for patients with psychiatric illness. Smokers are more likely to be readmitted within 30 days or one year after discharge. Interaction of smoking and certain specific diagnoses significantly increases readmission.

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Factors associated with readmission to the hospital within 30 days in patients with inflammatory bowel disease

Cited by 45 publications

References 30 publications

Association between cannabis use and complications related to ulcerative colitis in hospitalized patients

Association between cannabis use and complications related to ulcerative colitis in hospitalized patients

Systematic Review: Components of a Comprehensive Geriatric Assessment in Inflammatory Bowel Disease—A Potentially Promising but Often Neglected Risk Stratification

Association between smoking, and hospital readmission among inpatients with psychiatric illness at an academic inpatient psychiatric facility, 2000–2015

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