Factors associated with recovery of haemoglobin levels after whole‐blood donation in the French West Indies in 2015

Malard, Lucile; Richard, Pascale; Maire, F.; Djoudi, Rachid; Gross, Sylvie; Fillet, Anne‐Marie

doi:10.1111/tme.12563

Cited by 4 publications

(5 citation statements)

References 10 publications

(16 reference statements)

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“…This non‐increasing risk of ID for donors of Afro‐Caribbean origin, either from our study in French West‐Indies or from African‐American donors, in comparison with Caucasian‐non‐Hispanic donors, is a very interesting new information and could be analysed with recent REDS‐III RBC‐Omics study results showing that African–American background was associated with resistance to osmotic haemolysis compared with other ethnic groups [20]. Indeed, the mean level of haemoglobin is lower in donors of Afro‐Caribbean origin, either from our previous study of WB donors in 2015 in French West‐Indies (12·9 g/dl for women, 14·7 g/dl for men) [6] or from US American African donors (12·9 g/dl for women and 14·4 g/dl for men), than in Caucasian‐non‐Hispanic donors (13·4 g/dl for women, 15·1 g/dl for men) [21]. In donors of Afro‐Caribbean origin, the mean low level of haemoglobin is very probably not linked with prevalence of ID which is usual.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, haemoglobin thresholds in France are 0Á5 g/dl under the European threshold (that is 13 g/dl for men donors and 12 g/dl for women donors). This adapted threshold was a specific request of France to take into account the donors of Afro-Caribbean origin from overseas departments and territories, who have an average haemoglobin level lower than metropolitan donors [6] and then to preserve self-sufficiency in those areas. Donor monitoring has been reinforced by performing a systematic blood count for all donations.…”

Section: Introductionmentioning

confidence: 99%

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Iron deficiency among French whole‐blood donors: first assessment and identification of predictive factors

et al. 2020

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Background The objectives of this study are to estimate the prevalence of iron deficiency (ID) among French whole‐blood (WB) donors to identify factors associated with ID and to generate decision trees. Study design and methods A prospective National multicentre study was performed on WB donors from March 11, to April 5th, 2019. Samples were selected randomly to perform serum ferritin. ID was defined as ferritin value under 26 ng/ml. All results were stratified by sex. Factors associated with ID were analysed using multivariate logistic regression model. CART algorithm was used for decision trees. Results Eleven thousand two hundred fifty eight WB donors were included. ID was more frequent in women (39·5%) than in men (18·0%). Among 7200 repeated donors, women below 50 yo had a higher risk (OR = 2·37; [1·97–2·85] IC95) than those above 50 yo. Factors associated with ID were: haemoglobin level under the threshold at donation n‐1 except for women and n‐2 donation; a low mean corpuscular haemoglobin at n‐1 and n‐2 donations; a shorter interval since n‐1 donation and between n‐1 and n‐2 donations except for women; and women who had given three or four times in the last year. CART algorithm defined high risk of ID subgroups within three populations of donors, new female donors, repeated male donors and repeated female donors. In these identified subgroups, prevalence of ID was up to 72·1%. Conclusions Our study showed the high prevalence of ID among French WB donors, identified well‐known and new factors associated with ID and defined algorithms predicting ID in three populations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Iron deficiency among French whole‐blood donors: first assessment and identification of predictive factors

et al. 2020

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“…Meta-analysis of 13 studies which reported LHD rates found no difference in the risk of LHD between new and repeat donors (OR 0.80, 95%CI 0.58-1.10) ( Figure 6). In addition, a study from Thailand [47] reported only deferral percentages for repeat and new donors and found a higher percentage of LHDs for regular donors than new donors, whereas a study from the Caribbean [49] observed the opposite effect. The risk of LHD in new and repeat donors is likely to be confounded by the number and intensity of donations in individual studies which may contribute to the high heterogeneity observed across…”

Section: Donation Characteristicsmentioning

confidence: 99%

Donor Deferral Due to Low Hemoglobin—An Updated Systematic Review

Browne

Fisher

Masconi

et al. 2020

Transfusion Medicine Reviews

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Background/Objectives: Blood donors attending a donation session may be deferred from donating blood due to a failure to meet low hemoglobin (Hb) thresholds. This costs the blood donor service, and donors, valuable time and resources. In addition, donors who are deferred may have more symptoms and as a direct and/or indirect effect of their experience return rates of donors deferred for low Hb are reduced, even in repeat donors. It is therefore vital that low Hb deferral (LHD) is minimized. The aim of this updated systematic review is to expand the evidence base for factors which affect a donor's risk of deferral due to low Hb. Materials/Methods: Studies were identified by searching MEDLINE, Embase, The Cochrane Library and the WHO International Clinical Trials Registry to March 2019. Demographic data, donor history, hematological/biological factors and the primary outcome of deferral due to low Hb were extracted. Our primary outcome was deferral due to low Hb. Analyses were descriptive and quantitative; pooled odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by meta-analysis using random effects models. Results: A total of 116 studies met the inclusion criteria. Meta-analysis showed a significantly greater risk of LHD in females compared with males in studies applying universal Hb thresholds for males and females (OR 14.62 95%CI 12.43-17.19) and in those which used sex-specific thresholds (OR 5.73, 95%CI 4.36-7.53). Higher rates of LHD were also associated with increasing age in men, low body weight, shorter inter-donation interval, donors of Hispanic or African descent, higher ambient temperature, donors with low ferritin levels and donation in a fixed donor center. There was conflicting evidence on the effect of new and repeat donor status, and blood group. Conclusion: This work has strengthened the evidence of the previous review in identifying factors that should be considered in studies of donor deferral and highlighting areas in need of further study, including ABO and Rh blood groups, previous platelet donation, diet, smoking, time of day, and genetic data. These factors may lead to individually tailored donation criteria for safe and efficient donation in the future.

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“…Below a Hb threshold of 13 g/dl for males and 12 g/dl for females, defining anaemia, donors are deferred for 6 months. These thresholds are 0.5 g/dl below the European thresholds considering French West Indies donors whose Hb values are lower than those of the Caucasian populations [2].…”

Section: Introductionmentioning

confidence: 99%

Impact of donor ferritin testing on iron deficiency prevention and blood availability in France: A cohort simulation study

et al. 2022

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Background and Objectives Implementing a ferritin testing policy for whole blood (WB) donors may prevent iron deficiency (ID, ferritin <26 ng/mL) and anaemia, but may induce donation losses. As part of a national prevention plan in France, we aimed to estimate its impact on ID, anaemias and WB donations among donors at high risk of ID. Materials and Methods A micro‐simulation model was developed to evaluate different scenarios compared to the current situation without ferritin testing as a reference scenario. The following scenarios were simulated: a minimum scenario with a 6‐month deferral for donors with absent iron store (AIS, ferritinemia <15 ng/ml), a main scenario with additional delayed invitations for donors with ferritinemia 15–25 ng/ml and a supplementation scenario with additional iron supplementation for 50% of the donors with AIS. Results In the main scenario, 52,699 WB donations per year were estimated to be lost after 1 year (−8%), falling to 27,687 (−4.7%) after 5 years. IDs and anaemias were reduced by 13.6% and 29.3%, respectively, after 1 year. The supplementation scenario increased the number of prevented IDs and anaemias to 24.1% and 35.4%, respectively, after 1 year, and halved the number of anaemias at 5 years. The latter scenario also had the least impact on the number of donations (−3.2% after 5 years). Conclusion A ferritin testing policy resulting in delayed donations for ID donors is effective in reducing IDs and anaemias, but significantly impacts the number of donations, thereby posing a self‐sufficiency challenge.

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Factors associated with recovery of haemoglobin levels after whole‐blood donation in the French West Indies in 2015

Cited by 4 publications

References 10 publications

Iron deficiency among French whole‐blood donors: first assessment and identification of predictive factors

Iron deficiency among French whole‐blood donors: first assessment and identification of predictive factors

Donor Deferral Due to Low Hemoglobin—An Updated Systematic Review

Impact of donor ferritin testing on iron deficiency prevention and blood availability in France: A cohort simulation study

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