Factors Associated with Recurrence of Intracranial Meningiomas After Surgical Resection: A Retrospective Single-Center Study

Yang, Chao‐Hsun; Tsai, Cheng-Chia; Chen, Shiu‐Jau; Chiang, Ming-Fu; Lin, Jiunn-Yuan; Hu, C. K.; Chan, Yun-Kai; Lin, Hsin‐Yao; Cheng, Shih‐Jung

doi:10.1016/j.ijge.2017.02.002

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…We also found that sex and age at diagnosis were not associated with tumor recurrence in patients of meningioma with preoperative PTE, which is consistent with previously published ndings [35]. Besides, we believed that brain invasion and edema index were not signi cant predictors of recurrence in patients with preoperative PTE of meningioma.…”

Section: Discussionsupporting

confidence: 92%

“…Although their study was based on the comparison between patients with preoperative PTE and patients without preoperative PTE which is different from our research, we can infer that postoperative PTE means brain invasion and the invaded brain tissue may be also be the sources of residual cells leading to tumor recurrence after resection. Most of the previous studies suggest that generation of preoperative PTE is more related to WHO grades and extent of resection (EOR)[16,35]. Meanwhile, we found high WHO grades is one of the risk factors of tumor recurrence in patients of meningioma with preoperative PTE.…”

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confidence: 49%

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Postoperative peritumoral edema can predict the prognosis in intracranial meningioma with preoperative peritumoral edema

Ying

Dong

et al. 2023

Preprint

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Purpose Peritumoral edema (PTE) in intracranial meningiomas correlates to surgical outcomes. But only depending on preoperative PTE in meningioma does not accurately predict the prognosis after resection. We aimed to investigate whether postoperative PTE could improve the prognosis prediction of meningioma patients with preoperative PTE. Methods We retrospectively reviewed postoperative MRI scans in 3 months after operation of 371 patients with preoperative PTE of meningioma that underwent surgery between 2015 and 2017. All the patients were classified into two different groups according to whether had postoperative PTE fadeaway within 3 months after operation. Clinical manifestations, histopathology characteristics, radiology data and follow-up outcomes were noted. T-tests and chi-square tests were used to compare clinical characteristics. Univariate and multivariate Cox analysis and Kaplan‒Meier method were utilized to screen for clinical prognostic factors. Result Kaplan-Meier model showed that the progression-free survival of patients with postoperative PTE are shorter than who with postoperative PTE fadeaway in 3 months after operation (HR = 3.30 ,P = 0.006). Multivariate Cox analyses showed that the predictors for recurrence of meningioma with preoperative: high WHO grades (HR = 4.989, P＜0.001), superior sagittal sinus invasion (HR = 2.290, P = 0.047), postoperative PTE in 3 months after operation (HR = 1.804, P = 0.044) and subtotal resection (HR = 3.940, P = 0.003). Conclusion According to our research, we found that postoperative PTE in 3 months after operation can predict the outcomes of patients of meningioma with preoperative PTE. Besides, we demonstrated that there were also some predictors for recurrence: male, high WHO grades, superior sagittal sinus invasion and subtotal resection.

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Section: Discussionsupporting

confidence: 92%

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confidence: 49%

Postoperative peritumoral edema can predict the prognosis in intracranial meningioma with preoperative peritumoral edema

Ying

Dong

et al. 2023

Preprint

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“…7 12 Dari semua studi meningioma yang telah terpublikasi, semua kasus meningioma menunjukkan mayoritas adalah grade I disusul oleh grade II dan grade III sebagai kasus yang paling sedikit. 13 Sama halnya yang terjadi pada penelitian ini, sebesar 82,6% terdiri dari meningioma grade I, 15,3% untuk grade II, dan 1,3% untuk grade III.…”

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Perbedaan ekspresi Vascular Endothelial Growth Factor (VEGF) pada meningioma risiko rendah dan risiko tinggi di RSUP Sanglah, Bali, Indonesia

Sitanggang¹,

Sriwidyani²,

Sumadi³

et al. 2021

Intisari Sains Medis

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“…The majority of meningiomas (70-80%) are surgically resected [10]. However, the extent of the resection remains an essential factor of tumor recurrence [11,12]. Surgically unreachable meningiomas are more prone to inadequate and partial resection and/or may display malignant behavior (WHO grade II and III).…”

Section: Introductionmentioning

confidence: 99%

Meningioma genomics: a therapeutic challenge for clinicians

Moussalem¹,

Massaad²,

Minassian³

et al. 2021

J. Integr. Neurosci.

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Meningiomas are amongst the most commonly encountered intracranial tumors. The majority of these tumors arise intracranially, and the remaining incidents occur along the spinal cord. Meningiomas tend to grow gradually, with many tumors arising in inaccessible locations. Such sporadic behavior poses a therapeutic challenge to clinicians, causing incomplete tumor resections that often lead to recurrence. Therefore, ongoing research seeks to find alternative systematic treatments for meningiomas, with gene-based therapeutics of high interest. Subsequently, genetic studies characterized frequent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA. These genes are communally exhibited in 80% of sporadic meningiomas. In addition, other genes such as the DUSP family, the NR4 family, CMKOR, and FOSL2, have been identified as key players in spinal meningiomas. In this perspective, we aim to investigate current genetic-based studies, with the ongoing research mainly focused on the above NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA genes and their involved pathways. In addition, this perspective can serve as a potential cornerstone for future genetic analyses of meningioma cases.

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Factors Associated with Recurrence of Intracranial Meningiomas After Surgical Resection: A Retrospective Single-Center Study

Cited by 11 publications

References 36 publications

Postoperative peritumoral edema can predict the prognosis in intracranial meningioma with preoperative peritumoral edema

Postoperative peritumoral edema can predict the prognosis in intracranial meningioma with preoperative peritumoral edema

Perbedaan ekspresi Vascular Endothelial Growth Factor (VEGF) pada meningioma risiko rendah dan risiko tinggi di RSUP Sanglah, Bali, Indonesia

Meningioma genomics: a therapeutic challenge for clinicians

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