Factors Associated With Risk of Postdischarge Thrombosis in Patients With COVID-19

Пин, Ли; Zhao, Wei; Kaatz, Scott; Latack, Katie; Schultz, Lonni; Poisson, Laila

doi:10.1001/jamanetworkopen.2021.35397

Cited by 51 publications

(44 citation statements)

References 27 publications

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“…The relationship between a history of VTE and thrombosis in COVID-19 patients has been previously described [16]; thus, one of the factors that may have played a significant role in the association between Spanish and thrombosis was that seven of the eight subjects with a previous VTE were from Spain. Interestingly, the odds of thrombosis were 4.7 times higher in current smokers compared with former and non-smokers, coinciding with previous reports that indicate that, despite controversial findings, current, former, and heavy smokers have an elevated risk for thrombotic events [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 83%

Thromboembolic Events in a Socio-Economically Disadvantaged Population with COVID-19 Admitted to a Medicalized Hotel in Madrid

Ramírez-Cervantes

Huerta-Álvarez

Quintana-Díaz

2022

IJERPH

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The social determinants of health (SDOH) of patients with COVID-19-related thrombosis have been scarcely explored. Our objective was to investigate the cases of thrombosis in a group of socially disadvantaged populations with COVID-19. Methods: We investigated the thrombotic events that occurred in a cohort of migrant and Spanish patients with COVID-19 that were admitted to a medicalized hotel in Madrid. Demographic data, past medical history, and socio-economic backgrounds, such as monthly household income, level of education, and living conditions, were explored to determine the factors related to thrombosis. Results: A cohort of 383 subjects (mean age 55.4 ± 14.6 years old, 69% male), of which 58% were migrants, was studied. Fourteen (3.6%) cases of thrombosis were reported. Thrombosis was more frequent in Spanish than in migrant individuals (OR 5.3, 95%CI 1.4–19.5, p = 0.005). Neither a low monthly household income nor a low education level showed a statistical association with thrombosis (p ≥ 0.05). History of venous thromboembolism (OR 8.1, 95%CI 2.2–28.6) and being a current smoker (OR 4.7, 95%CI 1.3–16.0) were factors associated with thrombosis. Conclusions: The SDOH studied were not associated with thrombosis; however, further investigation must be performed to investigate the socio-economic conditions of subjects with COVID-19 with adverse outcomes such as thrombotic events.

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Section: Discussionmentioning

confidence: 83%

Thromboembolic Events in a Socio-Economically Disadvantaged Population with COVID-19 Admitted to a Medicalized Hotel in Madrid

Ramírez-Cervantes

Huerta-Álvarez

Quintana-Díaz

2022

IJERPH

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“…Fourth, the immune response against SARS-CoV-2 led to hypercoagulability or dysfunctional thrombocytes and thus to intra-atrial or intra-arterial thrombus formation. Arguments in favor of this hypothesis are that thrombus formation is a well-known complication of SARS-CoV-2 infections [ 5 - 6 ] and that embolic stroke has been repeatedly reported in association with SARS-CoV-2 infection [ 1 - 2 ]. Fifth, the infection with SARS-CoV-2 caused cerebral vasculitis, endothelialitis, or endothelial dysfunction, which are suspected to contribute to the pathophysiology of ischemic stroke in COVID-19 patients [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Ischemic Stroke in a SARS-CoV-2-Positive Octagenarian Without Cardiovascular Risk Factors: A Case Report

Finsterer¹

2022

Cureus

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Ischemic and hemorrhagic strokes are increasingly recognized as complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The absence of cardiovascular risk factors in SARS-CoV-2-infected patients who suffer a stroke supports a causal relationship as shown in the following report. The patient is an 86-year-old female who developed a mild, brachio-facial, right-sided hemi-symptomatic during a mild infection with SARS-CoV-2. Cerebral magnetic resonance imaging (MRI) showed a corresponding, small, subacute, ischemic lesion in the left periventricular white matter and a microbleed in the left thalamus. Under dual platelet aggregation inhibitor therapy, the neurological deficits regressed almost completely within three weeks. If one considers that classic cardiovascular risk factors were missing, a causal link between the SARS-CoV-2 infection and the stroke becomes likely. Vasculopathy, coagulopathy, and cardiac disease caused by the virus or the immune response against it serve as pathophysiological explanations for the cerebral lesions. It is concluded that ischemic stroke can occur during infection with SARS-CoV-2. There are more arguments for than against a causal relationship between the viral infection and ischemic stroke.

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“…Hence, thrombosis prophylaxis regimen has been recommended in moderate and severe cases 21 . In outpatient settings, thrombosis prophylaxis has been even suggested for high‐risk individuals 22 . Overall, several mechanisms have been speculated for thrombus formation in COVID‐19 patients including endothelial dysfunction, intercellular junction abnormalities, formation of microthrombi, coagulopathies, immune‐induced thrombosis, cytokine storm, and inflammation 21,23 …”

Section: Discussionmentioning

confidence: 99%

Left ventricular thrombosis and endogenous endophthalmitis in the setting of COVID‐19: A case report

Zibaeenezhad

Moaref

Abtahi

et al. 2022

Clinical Case Reports

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Factors Associated With Risk of Postdischarge Thrombosis in Patients With COVID-19

Cited by 51 publications

References 27 publications

Thromboembolic Events in a Socio-Economically Disadvantaged Population with COVID-19 Admitted to a Medicalized Hotel in Madrid

Thromboembolic Events in a Socio-Economically Disadvantaged Population with COVID-19 Admitted to a Medicalized Hotel in Madrid

Ischemic Stroke in a SARS-CoV-2-Positive Octagenarian Without Cardiovascular Risk Factors: A Case Report

Left ventricular thrombosis and endogenous endophthalmitis in the setting of COVID‐19: A case report

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