Factors associated with sedative use and misuse among heroin users

Moses, Tabitha E.H.; Lundahl, Leslie H.; Greenwald, Mark K.

doi:10.1016/j.drugalcdep.2017.11.035

Cited by 15 publications

(13 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overdose Individuals with opioid use, prescription drug misuse, or injection drug use Benzodiazepine misuse was retrospectively associated with non-fatal overdose (Bennett and Higgins, 1999;Dietze et al, 2005;Galea et al, 2006;Hakansson et al, 2008;Kerr et al, 2007;Kinner et al, 2012;Maloney et al, 2009;Mateu-Gelabert et al, 2017;Moses et al, 2018;Neale and Robertson, 2005;Rossow and Lauritzen, 1999;Silva et al, 2013b;Stein et al, 2017b;Wines et al, 2007) Benzodiazepine misuse was not retrospectively associated with overdose (Bouvier et al, 2018;Darke et al, 1996;Havens et al, 2011;Sherman et al, 2007) Benzodiazepine misuse was associated with overdose in unadjusted but not adjusted analyses (Calvo et al, 2017;Jenkins et al, 2011;Mcgregor et al, 1998;…”

Section: Referencesmentioning

confidence: 99%

“…Benzodiazepine misuse was associated with poorer selfreported quality of life Individuals with opioid use, illicit/prescription drug misuse, or injection drug use Benzodiazepine misuse was associated with poorer selfreported quality of life (Becker et al, 2007;Darke et al, 1993;Deacon et al, 2016;Lavie et al, 2009;Lugoboni et al, 2014;Millson et al, 2006) Ongoing benzodiazepine misuse during treatment was associated with poorer physical health (Darke et al, 2010;Eiroa-Orosa et al, 2010) Benzodiazepine misuse was associated with greater pain severity (Anagnostopoulos et al, 2018;Moses et al, 2018) Benzodiazepine misuse was associated with greater sleep dysfunction (Blanco et al, 2013;Manconi et al, 2017;Mazza et al, 2014;Peles et al, 2009) Other subgroups (e.g., healthcare workers, adolescents in the emergency department)…”

Section: Quality Of Life and Physical Healthmentioning

confidence: 99%

See 1 more Smart Citation

The epidemiology of benzodiazepine misuse: A systematic review

Votaw

Geyer

Rieselbach

et al. 2019

Drug and Alcohol Dependence

303

214

View full text Add to dashboard Cite

Background: Benzodiazepine misuse is a growing public health problem, with increases in benzodiazepine-related overdose deaths and emergency room visits in recent years. However, relatively little attention has been paid to this emergent problem. We systematically reviewed epidemiological studies on benzodiazepine misuse to identify key findings, limitations, and future directions for research. Methods: PubMed and PsychINFO databases were searched through February 2019 for peerreviewed publications on benzodiazepine misuse (e.g., use without a prescription; at a higher frequency or dose than prescribed). Eligibility criteria included human studies that focused on the prevalence, trends, correlates, motives, patterns, sources, and consequences of benzodiazepine misuse. Results: The search identified 1,970 publications, and 351 articles were eligible for data extraction and inclusion. In 2017, benzodiazepines and other tranquilizers were the third most commonly used illicit or prescription drug in the U.S. (approximately 2.2% of the population). Worldwide rates of misuse appear to be similar to those reported in the U.S. Factors associated with misuse include other substance use, receipt of a benzodiazepine prescription, and psychiatric symptoms and disorders. Benzodiazepine misuse encompasses heterogeneous presentations of motives, patterns, and sources. Moreover, misuse is associated with myriad poor outcomes, including mortality, HIV/HCV risk behaviors, poor self-reported quality of life, criminality, and continued substance use during treatment.

show abstract

Section: Referencesmentioning

confidence: 99%

Section: Quality Of Life and Physical Healthmentioning

confidence: 99%

The epidemiology of benzodiazepine misuse: A systematic review

Votaw

Geyer

Rieselbach

et al. 2019

Drug and Alcohol Dependence

303

214

View full text Add to dashboard Cite

show abstract

“…Benzodiazepines, whether used concurrently or simultaneously with opioids, increase the risk of respiratory depression leading to death [10]. Additionally, the use of opioids and benzodiazepines (O/BZD) is a well-documented high-risk behaviour pattern that also increases risks of other adverse consequences [11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

US national treatment admissions with opioids and benzodiazepines

Arfken

Owens

Greenwald

2020

Drug and Alcohol Review

Self Cite

View full text Add to dashboard Cite

Introduction and Aims. Opioids and benzodiazepines (O/BZD) are increasingly involved in drug overdose deaths in the USA. Expanding treatment capacity may reduce these deaths. Knowledge about co-occurring O/BZD admissions compared to opioid admissions (opioid) is needed to plan this expansion. Design and Methods. US treatment admissions to specialty facilities for 2011-2017 were analysed for trends and 2017 for group differences. Due to 1.9 million admissions in 2017, comparisons between O/BZD and opioid admissions were summarised as effect sizes. Additional analysis compared the administratively pre-coded category 'other opiates and synthetics' to other opiates and synthetics/benzodiazepines admissions to control for possible similarity in drug source. Differences within O/BZD admissions by primary drug were explored. Results. Although opioid admissions showed a steady increase over time (25.9% to 38.2%), O/BZD admissions showed increases until decline in 2017 (3.2% to 4.0%). In 2017 no factor reached moderate effect size (≥0.2) in group comparisons or within the O/BZD admissions. Heroin was self-reported in 70% of both O/BZD and opioid admissions. Discussion and Conclusions. No meaningful US national differences on data routinely collected were found for O/BZD compared to opioid admissions including the subgroup with other opiates and synthetics only. Efforts to expand existing opioid treatment in specialty treatments may help reduce opioid and O/BZD deaths. However, the analysis could not address whether changes in treatment would improve outcomes.

show abstract

“…Furthermore, amongst heroin abusers, there is a trend of concurrent addiction and abuse of multiple substances, especially cannabis, cocaine, benzodiazepines and alcohol [5]. These factors have significantly worsened their mental health and increased the number of emergency visits and drug overdoses amongst this population [6].…”

Section: Introductionmentioning

confidence: 99%

Heroin Overdose-Related Child and Adolescent Hospitalizations: Insight on Comorbid Psychiatric and Substance Use Disorders

Queeneth

Bhimanadham

Mainali

et al. 2019

Behavioral Sciences

View full text Add to dashboard Cite

Objective: To evaluate the association between psychiatric comorbidities, substance use disorders and heroin overdose-related hospitalizations (HOD). Next, to understand the demographic trend of HOD hospitalizations and comorbidities. Methods: Using the Nationwide Inpatient Sample (NIS), we included 27,442,808 child and adolescent hospitalizations, and 1432 inpatients (0.005%) were managed primarily for HOD. The odds ratio (OR) of the association of variables in HOD inpatients were measured using a logistic regression model. Results: Adolescents had 56 times higher odds (95% CI 43.36–73.30) for HOD-related hospitalizations compared to 4.6% children under 11 years. About three-fifth of the HOD inpatients were male, and they had 1.5-fold higher odds (95% CI 1.30–1.64) compared to 43% females in the study population. Whites were considerably higher in proportion (81%) than other race/ethnicities. A greater portion of HOD inpatients (40%) were from high-income families. Most common comorbid psychiatric disorders were mood (43.8%) and anxiety (20.4%). The prevalent comorbid substance use disorders were opioid (62.4%), tobacco (36.8%) and cannabis (28.5%) use disorders. Conclusion: HOD-related hospitalizations were predominant in males, White and older adolescents (12–18 years). Prescription opioids are the bridge to heroin abuse, thereby increasing the vulnerability to other substance abuse. This requires more surveillance and should be explored to help reduce the heroin epidemic in children.

show abstract

Factors associated with sedative use and misuse among heroin users

Cited by 15 publications

References 36 publications

The epidemiology of benzodiazepine misuse: A systematic review

The epidemiology of benzodiazepine misuse: A systematic review

US national treatment admissions with opioids and benzodiazepines

Heroin Overdose-Related Child and Adolescent Hospitalizations: Insight on Comorbid Psychiatric and Substance Use Disorders

Contact Info

Product

Resources

About