Factors associated with severity of occupational asthma with a latency period at diagnosis

Descatha, Alexis; Leproust, H.; Choudat, D.; Garnier, R.; Pairon, Jean‐Claude; Ameille, J.

doi:10.1111/j.1398-9995.2007.01424.x

Cited by 28 publications

(20 citation statements)

References 38 publications

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“…Such selection is likely to occur in our study based on a population of late‐career nurses. Indeed, occupational asthma typically occurs after a latency period which can last from a few weeks to a few years, with an average of ~8 to 10 years . In addition, susceptibility (disease risk) to occupational exposure is known to vary between individuals; for instance, gene‐environment interactions have been reported in adult‐onset asthma related to occupational exposure to chemicals/irritants .…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study

Dumas

Boggs

Quinot

et al. 2019

American J Industrial Med

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Background: Exposure to disinfectants among healthcare workers has been associated with respiratory health effects, in particular, asthma. However, most studies are cross-sectional and the role of disinfectant exposures in asthma development requires longitudinal studies. We investigated the association between occupational exposure to disinfectants and incident asthma in a large cohort of U.S. female nurses. Methods: The Nurses' Health Study II is a prospective cohort of 116 429 female nurses enrolled in 1989. Analyses included 61 539 participants who were still in a nursing job and with no history of asthma in 2009 (baseline; mean age: 55 years). During 277 744 person-years of follow-up (2009-2015), 370 nurses reported incident physician-diagnosed asthma. Occupational exposure was evaluated by questionnaire and a Job-Task-Exposure Matrix (JTEM). We examined the association between disinfectant exposure and subsequent asthma development, adjusted for age, race, ethnicity, smoking status, and body mass index.Results: Weekly use of disinfectants to clean surfaces only (23% exposed) or to clean medical instruments (19% exposed) was not associated with incident asthma (adjusted hazard ratio [95% confidence interval] for surfaces, 1.12 [0.87-1.43]; for instruments, 1.13 [0.87-1.48]). No association was observed between high-level exposure to specific disinfectants/cleaning products evaluated by the JTEM (formaldehyde, glutaraldehyde, bleach, hydrogen peroxide, alcohol quats, or enzymatic cleaners) and asthma incidence. Conclusions:In a population of late career nurses, we observed no significant association between exposure to disinfectants and asthma incidence. A potential role of disinfectant exposures in asthma development warrants further study among healthcare workers at earlier career stage to limit the healthy worker effect. K E Y W O R D Sasthma, cleaning products, disinfection, healthcare workers, occupational asthma

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study

Dumas

Boggs

Quinot

et al. 2019

American J Industrial Med

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“…There is evidence form earlier studies that there are differences between OA caused by HMW and LMW agents in terms of clinical characteristics . A few studies investigated OA due to these two types of agents in terms of the baseline sputum inflammatory profile or the pattern of bronchial response and the changes in nonspecific bronchial hyperresponsiveness (BHR) and markers of airway inflammation induced by challenge exposures.…”

Section: Introductionmentioning

confidence: 99%

Are high‐ and low‐molecular‐weight sensitizing agents associated with different clinical phenotypes of occupational asthma?

Vandenplas

Godet²,

Hurdubaea

et al. 2018

Allergy

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“…Regardless of the prevalence of OA, little is known about its outcome and factors affecting it. The outcome can be evaluated by different measures, which include persistence of symptoms, employment rate, non‐specific bronchial hyperresponsiveness and lung function (4). The prognostic determinants that have been studied are, e.g.…”

Section: Introductionmentioning

confidence: 99%

Short-term prognosis of occupational asthma in a Finnish population

Kauppi

Hannu

Helaskoski

et al. 2010

The Clinical Respiratory Journal

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Background: Causative agents of occupational asthma (OA) are well described in literature but far less is known about factors affecting the outcome of OA. Short duration of exposure, early diagnosis when symptoms appear and further avoidance of exposure have been suggested as good prognostic factors. This study was designed to investigate a short-term outcome of OA. Methods: The medical records of 47 Caucasian patients from a Finnish population diagnosed with OA in year 2003 were reviewed retrospectively. Employment status at 6-month follow-up of all patients was determined. We assessed the following potential predictors of unemployment at follow-up: the causative agents of OA, asthma medication, spirometry results, smoking status, gender, age, occupation, atopy status, bronchial hyperresponsiveness and time to diagnosis. We calculated odd ratios (ORs) to predict employment status at follow-up. Results: At the follow-up examination, 23 persons (49%) were not working. At the time of follow-up there were no significant differences in pulmonary function between those employed and those who discontinued to work. Atopy at baseline predicted diminished lung function at the 6-month follow-up. In addition, atopy was the only prognostic factor and was inversely related to the work discontinuation at the follow-up [OR 0.18, 95% confidence interval (CI) 0.04-0.79]. Work continuation as an OA outcome at 6 months could not be predicted by gender, age, occupational status, exposure antigen, smoking habits or duration of symptoms before diagnosis. Conclusions: The socio-economic short-term prognosis of OA was relatively poor since half of the patients were not at work at the 6 months follow-up.Please cite this paper as: Kauppi P, Hannu T, Helaskoski E, Toivio P and Sauni R. Short-term prognosis of occupational asthma in a Finnish population. Clin Respir J 2011; 5: 143-149.

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Factors associated with severity of occupational asthma with a latency period at diagnosis

Abstract: Severity of occupational asthma with a latency period at diagnosis was associated with duration of symptoms before diagnosis, but not with the type of causal agent. This finding emphasizes the need for early diagnosis and avoidance of exposure.

Cited by 28 publications

References 38 publications

Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study

Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study

Are high‐ and low‐molecular‐weight sensitizing agents associated with different clinical phenotypes of occupational asthma?

Short-term prognosis of occupational asthma in a Finnish population

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