Factors associated with sexual dysfunction in Jordanian women and their sexual attitudes

Ali, Ruba M. Abu; Hajeri, Rabaa M. Al; Khader, Yousef; Ajlouni, Kamel

doi:10.4103/0256-4947.55312

Cited by 16 publications

(8 citation statements)

References 9 publications

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“…Regardless of whether it is developed from scratch or translated from other languages, the ideal instrument should be psychometrically tested for reliability and validity. Arabic translations of the FSFI have been used before to assess the female sexual function in the Arabic‐speaking populations; however, those translations were not validated [21–23]. The present study is the first study to validate an Arabic version of the FSFI.…”

Section: Discussionmentioning

confidence: 92%

Arabic Translation of Female Sexual Function Index and Validation in an Egyptian Population

Anis

Gheit

Saied

et al. 2011

The Journal of Sexual Medicine

166

128

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Introduction Female sexual dysfunction (FSD) is a prevalent health problem thathas been inadequately investigated in the Arab world. An Arabic assessment instrument for FSD is urgently needed. Aim To validate the Arabic version of the Female Sexual Function Index (ArFSFI). Methods This is a cross-sectional study conducted between January and April 2010. Eight hundred and fifty-five women (16–60 years old) participated in the study. Validation was carried out on aspects of face, content, discriminant, and criterion (concurrent) validity. Construct validity was evaluated using principal component analysis. Reliability studies on test–retest and on internal consistency were conducted with Pearson correlation and Cronbach’s alpha, respectively. The best cutoff point for the ArFSFI to differentiate cases and noncases was determined using a receiver operating characteristic (ROC) curve. Main Outcome Measure Parameters of validity and reliability of the ArFSFI and its domains. Results ArFSFI total score and scores of various domains showed high test–retest reliability (r from 0.92 to 0.98). ArFSFI domains showed high internal consistency (α from 0.85 to 0.94). Six hundred and forty-four women (75.32%) met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for diagnosis of sexual dysfunction while 211 women (24.68%) showed normal function. The ArFSFI was found to have good discriminant validity. There were significant differences between the mean scores of women with sexual dysfunction and those of women without sexual dysfunction. A total score of 28.1 was taken as the cutoff point for the ArFSFI to distinguish between women with FSD and women with normal function (sensitivity 96.7%, specificity 93.2%). The ArFSFI showed an excellent overall performance (area under the curve [AUC] = 0.985, 95% confidence interval 0.978–0.992). Conclusion The ArFSFI is a validated, reliable, and locally accepted tool for use in the assessment of FSD in the Egyptian population.

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Section: Discussionmentioning

confidence: 92%

Arabic Translation of Female Sexual Function Index and Validation in an Egyptian Population

Anis

Gheit

Saied

et al. 2011

The Journal of Sexual Medicine

166

128

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“…Female sexual dysfunction (FSD) and the associated risk factors are less studied in the Middle East. [ 1 2 3 4 5 6 ]…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated risk factors of female sexual dysfunction among Jordanian women

Maaita

Khreisat

Tasso

et al. 2018

J Family Med Prim Care

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Background:Female sexual dysfunction (FSD) and the associated risk factors are less studied in the Middle East. This study is designed to determine the prevalence of FSD and its associated risk factors in Jordan.Materials and Methods:A group of women were interviewed using detailed questionnaire on several aspects of FSD including desire, arousal, lubrication, orgasm, satisfaction, and pain disorders. They underwent sociodemographic investigation. Prevalence and risk factors of FSD are calculated in different age groups.Results:A total of 470 women aged 32.6 ± 9.6 years are included in this study. Desire problems were detected in 49.4% (232/470) of the studied women, while an arousal problem in 31.9% (150/470) and lubrication problem in 39.2% (184/470). An orgasm problem was detected in 39.57% (186/470) of the studied women, while satisfaction problem was detected in 43.82% (206/470) and pain problem during sexual relation in 19.2% (90/470). There was positive significant correlation between each domain of the FSD and the studied women's age except pain. FSD was found to be significant in women with more than four children (83.3%, P < 0.02), those who had been married for more than 10 years (76.7%, P < 0.02), in women with chronic medical diseases (76.7%, P < 0.02), in unemployed women (76.7%, P < 0.02), and in women not using contraception (75.2%, P < 0.005). There was no significant correlation with the level of education (P < 0.34) and monthly income (P < 0.24).Conclusion:The prevalence of FSD in Jordan is about 64.7%, the desire disorders are the most prevalent domain of FSD, and age is the most significant risk factor for FSD. Further research is needed with larger and more comprehensive sample to estimate the magnitude of FSD and to confirm its relationship with different risk factors.

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“…Met is known to be HIF1α regulated and is a key contributor to the invasive phenotype of NSCLC (35). Therefore, we treated H23 cells with VEGF alone or in combination with the c-Met inhibitor EMD1214063 and evaluated the effect on tumor cell migration.…”

Section: Resultsmentioning

confidence: 99%

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

Nilsson

Giri

Gudikote

et al. 2016

Clinical Cancer Research

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Purpose VEGF pathway inhibitors have been investigated as therapeutic agents in the treatment of non–small cell lung cancer (NSCLC) because of its central role in angiogenesis. These agents have improved survival in patients with advanced NSCLC, but the effects have been modest. Although VEGFR2/KDR is typically localized to the vasculature, amplification of KDR has reported to occur in 9% to 30% of the DNA from different lung cancers. We investigated the signaling pathways activated downstream of KDR and whether KDR amplification is associated with benefit in patients with NSCLC treated with the VEGFR inhibitor vandetanib. Methods NSCLC cell lines with or without KDR amplification were studied for the effects of VEGFR tyrosine kinase inhibitors (TKI) on cell viability and migration. Archival tumor samples collected from patients with platinum-refractory NSCLC in the phase III ZODIAC study of vandetanib plus docetaxel or placebo plus docetaxel (N = 294) were screened for KDR amplification by FISH. Results KDR amplification was associated with VEGF-induced activation of mTOR, p38, and invasiveness in NSCLC cell lines. However, VEGFR TKIs did not inhibit proliferation of NSCLC cell lines with KDR amplification. VEGFR inhibition decreased cell motility as well as expression of HIF1α in KDR-amplified NSCLC cells. In the ZODIAC study, KDR amplification was observed in 15% of patients and was not associated with improved progression-free survival, overall survival, or objective response rate for the vandetanib arm. Conclusions Preclinical studies suggest KDR activates invasion but not survival pathways in KDR-amplified NSCLC models. Patients with NSCLC whose tumor had KDR amplification were not associated with clinical benefit for vandetanib in combination with docetaxel.

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Factors associated with sexual dysfunction in Jordanian women and their sexual attitudes

Cited by 16 publications

References 9 publications

Arabic Translation of Female Sexual Function Index and Validation in an Egyptian Population

Arabic Translation of Female Sexual Function Index and Validation in an Egyptian Population

Prevalence and associated risk factors of female sexual dysfunction among Jordanian women

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

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