Factors associated with spontaneous adverse drug reaction reporting among healthcare professionals in Vietnam

Abstract

What is known and objective: Under-reporting is a major drawback of a voluntary adverse drug reaction reporting system in pharmacovigilance. However, little is known about facilitators and barriers to ADR reporting by healthcare professionals (HCPs) in developing countries. To investigate factors associated with adverse drug reaction (ADR) reporting among HCPs in Vietnam. Methods: A cross-sectional survey of 2091 HCPs was conducted in 2015 at 10 hospitals throughout Vietnam. The binary outcome was ever reporting ADRs. Healthcare professionals knowledge, attitude and practice about ADR reporting were measured. Multiple logistic regression analyses examined factors significantly associated with ever ADR reporting. Results: Overall, 29.3%, 2.2% and 68.4% of the sample were doctors, pharmacists and nurses, respectively. More than half (59.3%) had ever reported any ADR. Facilitators for ADR reporting were educational training (OR = 1.77, 95%CI = 1.42-2.22) and having better knowledge, such as awareness of ADR reporting regulation (OR = 1.63, 95%CI = 1.19-2.21), of reporting time (OR = 1.76, 95%CI = 1.35-2.29) and of necessary information in reporting form (OR = 1.94, 95%CI = 1.53-2.45).Conversely, barriers to non-reporting were unknown of reporting procedure (OR = 0.27, 95%CI = 0.22-0.35), unavailability of reporting form (OR = 0.54, 95%CI = 0.42-0.68) and lack of time (OR = 0.59, 95%CI = 0.46-0.74). What is new and conclusion: Given the low ADR reporting rate among HCPs, educational interventions to improve their knowledge and attitude should be prioritized in Vietnam. Additional interventions addressing obstacles (i.e. availability and complexity of reporting form, lack of time) should be considered to improve both the quantity and quality of ADR reporting.

An Exploration of Knowledge, Attitude, and Practices of Physicians toward Pharmacovigilance at Tertiary Care Hospitals in Khyber-Pakhtunkhwa Province, Pakistan

“…6 Spontaneous ADR reporting is an effective way of generating ADR signals, and physicians play a crucial role in spontaneous ADR reporting. 7,8 Physicians observe ADRs in their daily practice, yet the percentage of ADRs reported is significantly low. 9 Previous studies have documented numerous factors, including physicians' knowledge and attitude, that could cause underreporting of ADRs by physicians and contribute to the public health catastrophe.…”

Knowledge, attitudes and practices of health care professionals towards adverse drug reaction reporting in public sector primary health care facilities in a South African district

“…Health care professionals (HCPs), especially in LMICs, should work together to remove barriers to ADR reporting across sectors and establish effective pharmacovigilance systems [15,17,[19][20][21][22][23][24]. This includes physicians, pharmacists and nurses in ambulatory care in LMICs including South Africa [25][26][27][28][29].…”

“…Many factors are associated with ADR under-reporting among HCPs, referred to as 'the seven deadly sins' of pharmacovigilance [38]. These include a lack of knowledge about the necessary forms, ignorance of the rules and procedures and type of events that must be reported and lack of time and inertia, as well as lack of education among all key stakeholder groups [12,16,17,19,21,23,24,[37][38][39][40]. In addition, currently only a limited number of African countries have formal ADR reporting systems.…”

Barriers of healthcare professionals in utilizing the service of drugs and poison information Centre: A cross-sectional study

“…17 Community-based DIC tries to modify patient behaviour through medication therapy, resulting in improved patient adherence and thereby improving health care quality. 18 …”