Factors associated with the death of patients infected with the human immunodeficiency virus hospitalized in the gastroenterology department of the Campus Teaching Hospital of Lomé, Togo

Lawson-Ananissoh, Laté Mawuli; Bouglouga, O.; Bagny, A.; Yakoubou, Rafiou El-Hadji; Sewu, K.E.; Kaaga, L.; Rédah, D.

doi:10.1684/mst.2018.0817

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“…1 ). Only 9 studies [ 10 , 17 – 24 ] reporting OC in general HIV populations were included in the quantitative synthesis and 4 studies [ 25 – 28 ] in specific HIV populations were excluded from the meta-analyses. Overall, 9,150 patients were diagnosed with OC of the 113,272 HIV patients in SSA who were assessed between 1989 and 2014.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis

et al. 2020

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Background Esophageal candidiasis (OC) is a common AIDS-defining opportunistic infection. Antiretroviral therapy (ART) reduces the occurrence of OC and other opportunistic infections among persons living with HIV (PLHIV). We sought to determine and compare the prevalence of OC in the ART and pre-ART era among PLHIV in sub-Saharan Africa (SSA). Methods We searched PubMed, Embase, Web of Science, and the African Journals Online databases to select studies in English and French reporting the prevalence of HIV-associated OC in SSA from January 1980 to June 2020. Reviews, single-case reports, and case series reporting < 10 patients were excluded. A random-effect cumulative meta-analysis was performed using STATA 16.0, and trend analysis performed using GraphPad Prism 8.0. Results Thirteen eligible studies from 9 SSA countries including a total of 113,272 patients were qualitatively synthesized, and 9 studies were included in the meta-analysis. Overall pooled prevalence of HIV-associated OC was 12% (95% confidence interval (CI): 8 to 15%, I2 = 98.61%, p <. 001). The prevalence was higher in the pre-ART era compared to the ART era, but not to statistical significance (34.1% vs. 8.7%, p = 0.095). In those diagnosed by endoscopy, the prevalence was higher compared to patients diagnosed by non-endoscopic approaches, but not to statistical significance (35.1% vs. 8.4%, p = .071). The prevalence of OC significantly decreased over the study period (24 to 16%, p < .025). Conclusion The prevalence of OC among PLHIV in the ART era in SSA is decreasing. However, OC remains a common problem. Active endoscopic surveillance of symptomatic patients and further empirical studies into the microbiology, optimal antifungal treatment, and impact of OC on quality of life of PLHIV in SSA are recommended.

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Section: Resultsmentioning

confidence: 99%

“…The prevalence ranged from 1 to 52% across individual studies. Only two studies [ 17 , 18 ] were within the funnel plot, Fig. 3 .…”

Section: Resultsmentioning

confidence: 99%

Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

Factors associated with the death of patients infected with the human immunodeficiency virus hospitalized in the gastroenterology department of the Campus Teaching Hospital of Lomé, Togo

Cited by 1 publication

References 0 publications

Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis

Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis

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