2007
DOI: 10.1086/518619
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Factors Associated with the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study

Abstract: In addition to traditional risk factors, current treatment with protease inhibitor- and nucleoside reverse-transcriptase inhibitor-containing regimens was associated with the risk of developing type 2 diabetes mellitus. Our study did not find a significant association between viral hepatitis infection and risk of incident diabetes.

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Cited by 232 publications
(236 citation statements)
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“…5 Both HIV infection and use of antiretroviral medications to treat HIV may be risk factors for diabetes. [6][7][8] In the Multicenter AIDS Cohort Study, incidence of diabetes in HIV-infected men on antiretroviral therapy was more than four times greater than that of HIV-uninfected men, and both nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs) have been associated with incident diabetes among HIV-infected patients. [6][7][8] Overrepresentation of minorities in patients with HIV infection and diabetes may further contribute to the convergence of these two chronic diseases.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…5 Both HIV infection and use of antiretroviral medications to treat HIV may be risk factors for diabetes. [6][7][8] In the Multicenter AIDS Cohort Study, incidence of diabetes in HIV-infected men on antiretroviral therapy was more than four times greater than that of HIV-uninfected men, and both nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs) have been associated with incident diabetes among HIV-infected patients. [6][7][8] Overrepresentation of minorities in patients with HIV infection and diabetes may further contribute to the convergence of these two chronic diseases.…”
mentioning
confidence: 99%
“…Both NRTIs and PIs have been associated with insulin resistance and incident diabetes. [6][7][8]19 In addition to estimating the prevalence of inadequate glycemic control, the primary objective of this study was to assess possible risk factors for inadequate glycemic control in HIVinfected patients with diabetes receiving primary care in a large, urban, academic HIV clinic.…”
mentioning
confidence: 99%
“…Although insulin resistance was not reported in that study, 63% of HIV-infected subjects had co-infection with hepatitis C, which has been associated with increased risk of insulin resistance in some [24,25] but not all studies [26]. Injection drug users were excluded from the present study.…”
Section: Discussionmentioning
confidence: 88%
“…Isiolo County, a rural population in Northern Kenya reported prevalence of 16% [21]. The rising prevalence could partly be due to increased awareness about the disease, improved diagnosis [25] and prevalence of human immunodeficiency virus (HIV)/AIDS [26] which was 6.4% in women of western Kenya in 2007 [24]. HIV drugs have been associated with increased risk of DM2 [26] possibly due to associated obesity and cells developing insulin resistance [27].…”
Section: Prevalence Of Diabetes Mellitusmentioning
confidence: 99%
“…The rising prevalence could partly be due to increased awareness about the disease, improved diagnosis [25] and prevalence of human immunodeficiency virus (HIV)/AIDS [26] which was 6.4% in women of western Kenya in 2007 [24]. HIV drugs have been associated with increased risk of DM2 [26] possibly due to associated obesity and cells developing insulin resistance [27]. The women who participated in the focus group discussions (FGDs) also agreed that the prevalence of diabetes is rising.…”
Section: Prevalence Of Diabetes Mellitusmentioning
confidence: 99%