Factors Associated with the Occurrence of Metastatic Dissemination in Rectal Cancer

Abstract

Despite the development of preoperative neoadjuvant treatment, preoperative chemoradiotherapy in rectal cancer, metastases pose a challenge in the proper management of the disease, especially as they significantly reduce the 5-years survival rate [1,2]. The occurrence of metastases in rectal cancer disease is an additional important worrying factor not only in the patient but also in the surgeon due to their often-fatal outcome. The fact that up to 20% of patients with rectal cancer have metastatic disease at the stage of detection of the primary disease is challenging and should be taken with great concern [3,4].The latest research on the spread of metastases focuses on their development at the cellular and molecular level. Unfortunately, the epidemiological knowledge is still insufficient due to the fact that the registers for cancerous diseases do not always include the data for the Crimson PublishersWings to the Research