Objective: To explore the psychological health status of middle school students in China during the recent epidemic outbreak of “Novel Coronavirus Pneumonia” (NCP) and its influencing factors, and to provide a basis and suggestions for the adjustment of mental health of middle school students during the epidemic. Methods: A total of 2,007 middle school students were randomly selected nationwide to fill out a questionnaire. The questionnaire included basic personal and family information, life status and family relations during the epidemic, attitudes and pressures in the face of the epidemic, created by Chinese professor Zung. The anxiety self-assessment scale (SAS) compiled by SPSS statistical analysis software was used for data analysis to explore the changes in mental health during the epidemic. Results: Of the 2,007 valid questionnaires, according to the data using the self-rating anxiety scale, 424 students had anxiety, accounting for 21.1% of the total number; anxiety level of boys was higher than that of girls, and the anxiety level increased as the grade level increased. The student's personality, grade level, problem-solving methods, awareness and attention to the epidemic, parents' educational background, marital status, and family economic status all had an impact on the student's psychological status during the epidemic.Conclusion: The Novel Coronavirus Pneumonia epidemic has a great impact on the mental health of some middle school students. Family, school and social departments should pay attention to this phenomenon, care for their mental health, and take reasonable measures to actively intervene.