Factors associated with the risk of gingival disease in patients with rheumatoid arthritis

Huang, L.; Chen, Gin; Chen, Der‐Yuan; Chen, Hsin‐Hua

doi:10.1371/journal.pone.0186346

Cited by 8 publications

(5 citation statements)

References 45 publications

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“…Among the inflammatory diseases, periodontitis is one of the most common oral conditions with an inflammatory profile. 1,2 This disease is an inflammatory impairment that may mildly affect gingiva, resulting in bleeding, halitosis, and edema, or result in severe damage of dental supporting tissues, promoting damage of the gingiva, periodontal ligament, loss of attachment of alveolar bone and tooth loss. 3,4 The pathogenesis of periodontitis is a result of complex interactions between the periodontal pathogens and immune response.…”

Section: Introductionmentioning

confidence: 99%

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Ferreira

Silva

Magno

et al. 2019

Therapeutic Advances in Musculoskeletal

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Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis ( n = 1177) than controls ( n = 254) (OR 1.97; CI 1.68–2.31; p < 0.00001). However, considerable heterogeneity among studies was verified (I2 = 96%, p < 0.00001). Periodontitis may represent a risk factor for RA by heredity, bacterial infection, and the pro-inflammatory profile shared between both diseases. Although most of the elective studies report an association between periodontitis and RA, the quantitative analysis showed a high heterogeneity, leading to the need for further studies.

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Section: Introductionmentioning

confidence: 99%

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Ferreira

Silva

Magno

et al. 2019

Therapeutic Advances in Musculoskeletal

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“…Some single-center studies from China have reported the incidence of postoperative complications of CD to be 5.92-32.3%, among which the incidence of enterocutaneous stula accounted for 8.3-58.6% of the total complication rate. 4 Previous international studies have reported the incidence of postoperative complications of CD to be 5.0-40.9%, with the incidence of enterocutaneous stula accounting for 6.0-76.4% of the total complication rate. 5,6 Postoperative intestinal stula can cause changes such as abdominal infection, malnutrition, and multiorgan failure.…”

Section: Discussionmentioning

confidence: 98%

Postoperative intestinal fistula in Chinese patients with Crohn’s disease: a multicenter case-control study

Liu

Yang

et al. 2023

Preprint

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Background This study aimed to 1) assess the independent factors affecting patients with postoperative intestinal fistula from Crohn’s disease by analyzing preoperative clinical data, 2) establish a nomogram prediction model for this condition based on these factors, and 3) validate this model and evaluate its accuracy.Methods In this retrospective multicenter case-control study, the clinical data of 240 patients with Crohn’s disease admitted for surgical treatment between September 2017 and September 2019 at three centers were collected. Patients were randomly divided into a training set (168 patients) and a validation set (72 patients). Univariate analysis was performed for relevant factors, and statistically significant factors were then analyzed by multivariate logistic regression to determine the independent influencing factors. A nomogram model for predicting postoperative intestinal fistula in patients with Crohn’s disease was constructed and its accuracy of the model evaluated using calibration curves.Results Univariate analysis showed that disease behavior, abdominal abscess, intestinal perforation, neutrophil-to-lymphocyte ratio, systemic immunoinflammatory index, and prognostic nutrition index were factors affecting postoperative intestinal fistula in patients with Crohn’s disease. Multivariate logistic regression analysis showed that neutrophil-to-lymphocyte ratio, prognostic nutrition index, disease behavior, and Crohn's disease activity index score were independent influencing factors. After assessing the validation set, the area under the curve was 0.899, indicating good predictive accuracy of the nomogram model.Conclusions The prediction model developed in this study can effectively predict the risk of postoperative intestinal fistula.

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“…Many studies showed an increased prevalence of RA in patients with PD [25,26]. Others demonstrated the presence of RF in the gingiva, saliva, and serum of patients having PD [27,28].…”

Section: Discussionmentioning

confidence: 99%

Periodontal microbiota in a cohort of Egyptian patients with rheumatoid arthritis and their relation to serum and gingival anticitrullinated peptide protein antibodies and different disease parameters

Soliman

Abdelati

Fahmy

et al. 2018

Egypt Rheumatol Rehabil

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The possibility of infectious trigger at the gingival site in rheumatoid arthritis (RA) was reported in previous studies. The aim of our study is to determine the organisms causing periodontitis (PD) in a cohort of Egyptian patients with RA and their relation to serum and gingival anticitrullinated peptide protein antibodies (ACPA) level and other disease parameters. Patients and methods A prospective cohort study was conducted on 100 consecutive Egyptian patients with RA. Disease activity was assessed by applying disease activity score-28, and functional status was measured using health assessment questionnaire. Dental examination, serum rheumatoid factor, ACPA in serum and gingival crevicular fluid (GCF), and radiograph of the hands were done for all patients. GCF culture was performed for all cases with PD for Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), and Prevotella intermedia (Pi). ResultsOf the 100 patients, 66 patients had PD; of them, GCF culture was performed, and Pg, Aa, and Pi were found in 60.6, 15.2, and 30.3% of patients with RA with PD, respectively. Gingival ACPA showed significant higher level with Pg than Pi cases (P=0.047). No statistically significant difference was detected on comparing Pg with Aa or Aa with Pi. Aa-positive cases were associated with significantly higher level of C-reactive protein than Pi-positive cases (P=0.029), whereas no statistical significant difference was detected between Pgand Aa-positive or Pi-positive cases. ConclusionOur findings support the relationship between PD and infectious trigger at the gingival site and RA. Pg is the most prevalent periodontal microbiota in our cohort of patients with RA with PD that is associated with significant higher level of gingival ACPA. None of the detected organisms correlated with the degree of RA activity or other disease parameters, apart from significantly higher C-reactive protein level with Aa.

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Factors associated with the risk of gingival disease in patients with rheumatoid arthritis

Cited by 8 publications

References 45 publications

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Postoperative intestinal fistula in Chinese patients with Crohn’s disease: a multicenter case-control study

Periodontal microbiota in a cohort of Egyptian patients with rheumatoid arthritis and their relation to serum and gingival anticitrullinated peptide protein antibodies and different disease parameters

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