Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis

Cho, Soo-Kyoung; Kim, Dam; Won, Soyoung; Lee, Ji-Young; Choi, Chan-Bum; Choe, Jung‐Yoon; Hong, Seung‐Jae; Jun, Jae‐Bum; Kim, Tae‐Hwan; Koh, Eun‐Mi; Lee, Hye‐Soon; Lee, Sang Hoon; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang Cheol; Sung, Yoon‐Kyoung

doi:10.3904/kjim.2017.113

Cited by 25 publications

(21 citation statements)

References 16 publications

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“…Delayed diagnosis was usually found in RA patients with lower income. Higher education and higher income were factors associated with early diagnosis of RA [ 26 ]. Anti-CCP antibody positivity and low income represent severe risks for increasing time to diagnosis [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Socioeconomic Status in the Patients with Rheumatoid Arthritis

Yang

Huang

Chiou

et al. 2018

IJERPH

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Rheumatoid arthritis (RA) is a systemic inflammatory disease with different etiologies in different areas. Our study focused on the prevalence of RA in Taiwan from 2001 to 2011. This study contained longitudinal enrollment files, claims data, catastrophic illness files, and treatment registries from Taiwan Longitudinal Health Insurance Research Database. We identified RA patients by ICD-9-CM code 714.0. The demographical variables including age, sex, income and area of registration were evaluated. The multivariate Poisson regression was applied to calculate relative risk for developing RA. In Taiwan, the ratio of female to male was about 5:1. From 2001 to 2011, significant increasing prevalence of RA, from 0.07% to 0.14%, was found in women. The prevalence of RA was increasing 6% per year in both sex groups. The annual incidence rate (per 10,000 person years) ranged from 1.62 to 2.02 (female: 2.30–3.14; male: 0.71–1.17) from 2003 to 2011. City area had lowest incidence rate of RA compared with suburban or rural area. Higher incidence of RA was observed among lower socioeconomic status. The prevalence of RA was rising from 0.07% in 2001 to 0.14% in 2011. Incidence was about 2/10,000 person-years and female to male ratio was 5:1. Lower socioeconomic status and living rural region might be a risk factor for developing RA.

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Section: Discussionmentioning

confidence: 99%

Analysis of Socioeconomic Status in the Patients with Rheumatoid Arthritis

Yang

Huang

Chiou

et al. 2018

IJERPH

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“…Anti-citrullinated protein/peptide antibodies (ACPA) are the most specific biological markers with predictive and prognostic value in RA patients: they increase in 67% of patient sera five to ten years prior to diagnosis of RA [ 70 ]. Early diagnosis is considered a key factor for the most desired outcomes but until now it remains challenging because early symptoms and signs imitate those of several other diseases [ 71 , 72 ].…”

Section: Role Of Ncrnas In Rheumatoid Arthritismentioning

confidence: 99%

Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases

et al. 2020

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Immune responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled, autoimmune diseases can occur. Autoimmune diseases (ADs) are a family of disorders characterized by the body’s immune response being directed against its own tissues, with consequent chronic inflammation and tissue damage. Despite enormous efforts to identify new drug targets and develop new therapies to prevent and ameliorate AD symptoms, no definitive solutions are available today. Additionally, while substantial progress has been made in drug development for some ADs, most treatments only ameliorate symptoms and, in general, ADs are still incurable. Hundreds of genetic loci have been identified and associated with ADs by genome-wide association studies. However, the whole list of molecular factors that contribute to AD pathogenesis is still unknown. Noncoding (nc)RNAs, such as microRNAs, circular (circ)RNAs, and long noncoding (lnc)RNAs, regulate gene expression at different levels in various diseases, including ADs, and serve as potential drug targets as well as biomarkers for disease progression and response to therapy. In this review, we will focus on the potential roles and genetic regulation of ncRNA in four autoimmune diseases—systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, and type 1 diabetes mellitus.

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“…Due to strenuous pain and disability, RA can make patients withdraw from social life, opt for isolation, become dependent on other people, and become depressed. However, individual RA patients react differently to the limitations arising from their chronic disease and disability [7,8].…”

Section: Introductionmentioning

confidence: 99%

Adjustment in women treated for rheumatoid arthritis

Janiszewska¹,

Drop²,

Drop³

et al. 2021

Ann Agric Environ Med.

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Introduction. The favourable or unfavourable process of a patient's adaptation to a challenging medical condition may indicate that certain adjustment reactions, which can be either constructive or undesirable, tend to prevail. Objective. The aim of the study was to examine the adjustment reactions of patients, and to define the correlation between the reactions and socio-demographic factors, health self-assessment, satisfaction with medical care, duration of treatment, and limitations in women treated for rheumatoid arthritis. Materials and method. The study was conducted at the Department of Rheumatology and Connective Tissue Diseases and the Specialist Outpatient Clinic of the Independent Public Teaching Hospital No. 4 in Lublin, Poland. The Polish adaptation of the Reactions to Impairment and Disability Inventory RIDI (H. Livneh, R. Antonak, 1990) was used in the study, together with an Original Questionnaire. A p-value of <0.05 was set to define statistical differences. Analysis was performed using commercial SPSS Statistics software (IBM Corp., Armonk, NY). Results. Adjustment reactions, adaptive reactions, i.e. adjustment (3±0.5) and acknowledgement (2.6±0.4) were found to markedly prevail, while the lowest mean value was observed for denial (1.9±0.4), which was considered a negative reaction. Longer duration of the disease was associated with a lower level of external hostility. Low health self-assessment and significant limitations impairing everyday activities, caused by pain, deformity and impaired joint mobility, were mostly related to unfavourable early and intermediate non-adaptive reactions. Conclusions. Knowledge of the adjustment reactions and their moderating factors appears to be crucial in the planning of measures aimed at the rehabilitation of RA patients.

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Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis

Cited by 25 publications

References 16 publications

Analysis of Socioeconomic Status in the Patients with Rheumatoid Arthritis

Analysis of Socioeconomic Status in the Patients with Rheumatoid Arthritis

Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases

Adjustment in women treated for rheumatoid arthritis

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