Factors Associated With Tuberculin Reactivity in Two General Hospitals in Mexico

García-García, María de Lourdes; Jiménez-Corona, Aída; Jiménez-Corona, María Eugenia; Ferreyra-Reyes, Leticia; Martínez, Kenneth; Rivera-Chavira, Blanca Estela; Martínez-Tapia, María Elena; Valenzuela-Miramontes, Emilio; Palacios-Martínez, Manuel; Juárez-Sandino, Luis; Valdespino-Gómez, José Luis

doi:10.1086/501869

Cited by 25 publications

(26 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increasing age and duration of employment in the health-care facility (indicating longer cumulative exposure), were associated with higher prevalence of LTBI in most studies (Table 2). The prevalence of LTBI in HCWs increased by 1.04 times (95% CI 1.02 to 1.07) with each additional year of increase in age [26,31], and by 1.5 (95% CI 1.0 to 2.2) [23] to 2.4 (95% CI 1.1 to 5.0) [31] times with employment duration of more than 1 y. The prevalence of LTBI was 3-fold higher [28] with ≥10 y of employment.…”

Section: Resultsmentioning

confidence: 99%

“…As seen in Table 3, the prevalence of LTBI among nurses ranged from 43% to 87%. It was reported in eight studies that the prevalence of LTBI in nurses was higher than that in other HCWs (ranging from being 1.3% higher [22] to 35.6% higher [31]. One study, however [32], reported a lower prevalence in nurses, compared to other HCWs).…”

Section: Resultsmentioning

confidence: 99%

“…One study determined that administrative measures had little impact on the development of TB disease, but the study considered a period of only 1 y—a relatively short interval to detect changes in this outcome [44]. Two studies that measured the incidence of TB infection detected significant reduction within 1 y following the introduction of multiple infection-control measures [22,31]. In one of these studies [22], the incidence of active disease in HCWs actually increased over the study period, but this could have been due to an increasing HIV prevalence in HCWs, which was not measured.…”

Section: Discussionmentioning

confidence: 99%

“…In one of these studies [22], the incidence of active disease in HCWs actually increased over the study period, but this could have been due to an increasing HIV prevalence in HCWs, which was not measured. The other study [31] compared TB incidence rates in hospitals with different infection-control policies, and other differences identified between the hospitals could have confounded the estimates. Taken together, the limited available evidence suggests that a reduction in the risk of TB infection is possible with simple administrative controls, but this needs to be evaluated in larger, better-controlled studies.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review

et al. 2006

View full text Add to dashboard Cite

BackgroundThe risk of transmission of Mycobacterium tuberculosis from patients to health-care workers (HCWs) is a neglected problem in many low- and middle-income countries (LMICs). Most health-care facilities in these countries lack resources to prevent nosocomial transmission of tuberculosis (TB).Methods and FindingsWe conducted a systematic review to summarize the evidence on the incidence and prevalence of latent TB infection (LTBI) and disease among HCWs in LMICs, and to evaluate the impact of various preventive strategies that have been attempted. To identify relevant studies, we searched electronic databases and journals, and contacted experts in the field. We identified 42 articles, consisting of 51 studies, and extracted data on incidence, prevalence, and risk factors for LTBI and disease among HCWs. The prevalence of LTBI among HCWs was, on average, 54% (range 33% to 79%). Estimates of the annual risk of LTBI ranged from 0.5% to 14.3%, and the annual incidence of TB disease in HCWs ranged from 69 to 5,780 per 100,000. The attributable risk for TB disease in HCWs, compared to the risk in the general population, ranged from 25 to 5,361 per 100,000 per year. A higher risk of acquiring TB disease was associated with certain work locations (inpatient TB facility, laboratory, internal medicine, and emergency facilities) and occupational categories (radiology technicians, patient attendants, nurses, ward attendants, paramedics, and clinical officers).ConclusionsIn summary, our review demonstrates that TB is a significant occupational problem among HCWs in LMICs. Available evidence reinforces the need to design and implement simple, effective, and affordable TB infection-control programs in health-care facilities in these countries.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Other studies investigating the risk of physicians did not indicate an increased infection risk for physicians (Schablon et al, 2009).Other researchers reported a prevalence of LTBI in nurses; a subgroup with high level of patient contact, and thus potential exposure to TB cases (Joshi et al, 2006;Yanai et al, 2003;Garcia-Garcia et al, 2001). …”

Section: Discussionmentioning

confidence: 97%

Role of QuantiFERON-TB Gold In-Tube test in detection of latent tuberculosis infection in health care contacts in Alexandria, Egypt

Abdel¹,

Aziz²,

Hefnawy³

et al. 2014

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

Tuberculosis infection represents a global health problem and a great risk to health care workers. The detection and treatment of latent tuberculosis infection is a key strategy in the control of tuberculosis. The aim of this study was to estimate the usefulness of QuantiFERON-TB Gold In-Tube test which is an interferon-gamma release assay for the detection of latent tuberculosis infection, in a group of Egyptian Health Care Workers in comparison to the tuberculin skin test. A total of 100 Health Care Workers were enrolled. Subjects diagnosed as latent tuberculosis infection by tuberculin were 88% as compared to 36% by quantiferon. Higher tuberculin positive results were associated with direct contact to tuberculosis patients and job categories as physicians and nurses, while higher quantiferon positive results were associated with longer duration of employment and absence of BCG vaccination. The overall agreement between the two tests was poor (k=0.109). The negative discordant results (quantiferon negative/tuberculin positive) were 53% and were found among both contacts and non contact group, which could reflect high number of false positive tuberculin skin test. These data suggest that using IFN-γ method to screen new entrant health care workers for latent tuberculosis infection in our population could be more helpful because it is more specific for detecting latent tuberculosis infection compared to tuberculin skin test.

show abstract

Tuberculosis risk among nursing professionals from Central Brazil

Lopes¹,

Teles²,

Souza³

et al. 2008

American Journal of Infection Control

View full text Add to dashboard Cite

Factors Associated With Tuberculin Reactivity in Two General Hospitals in Mexico

Abstract: Although the studied population has a high baseline prevalence of tuberculosis infection and high coverage of BCG vaccination, nosocomial risk factors associated with PPD reactivity were identified as professional risks; strict early preventive measures must be implemented accordingly.

Cited by 25 publications

References 21 publications

Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review

Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review

Role of QuantiFERON-TB Gold In-Tube test in detection of latent tuberculosis infection in health care contacts in Alexandria, Egypt

Tuberculosis risk among nursing professionals from Central Brazil

Contact Info

Product

Resources

About