Background: Women empowerment has been viewed as a good strategy in the reduction of global maternal morbidity and mortality. Most of the recent studies in Uganda have focused on ANC frequency and the associated factors with no focus on the effect of women empowerment. Our study aims at examining the prevalence of optimal access to ANC by considering timing of initiation, type of ANC provider and ANC frequency and their association with women empowerment.Methods: We used Uganda Demographic and Health Survey (UDHS) 2016 data of 9957 women aged 15 to 49 years. Multistage stratified sampling was used to select study participants and we conducted multivariable logistic regression to establish the association between women empowerment and access to ANC using SPSS version 25. Results: Out of 9,957 women, 2,953 (29.7%: 95% CI: 28.5.0-30.2) had initiated ANC in first trimester, 6,080 (61.1%: 95% CI: 60.4-62.3) had 4 or more ANC contacts, and 9,880 (99.2%: 95% CI: 99.0-99.3) had received ANC from a skilled provider. Overall, 2,399 (24.1%: 95% CI: 23.0-24.6) had optimal access to ANC. Economic empowerment and exposure to media were the only women empowerment indices that were positively associated with optimal access to ANC. Other factors that were significant include; region, wealth index, age, level of education and working status. Women in younger age groups, those with higher wealth quintiles and those from the Northern and Western regions were also more likely to have optimal access to ANC compared to their older, poorest quintile and Eastern region counterparts respectively.Conclusion: To ensure increased access to ANC, policy-makers and other stakeholders should prioritize use of mass media in maternal health programs, equitable allocation of the limited financial resources with a focus on older, poor and uneducated women.