Factors connected with anxiety and other neuropsychiatric symptoms in advanced gastric cancer

Bryniarski, Paweł; Bryniarska, Magdalena; Jezioro, Maciej; Andrysiak, Daniel; Filipczak-Bryniarska, Iwona

doi:10.1017/neu.2021.27

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Page 6/11 [17] . Moreover, FKBP5 polymorphism is associated with anxiety and depression in patients with advanced gastric cancer [18] .…”

Section: Discussionmentioning

confidence: 99%

Impact of Negative Emotions on Upper Gastrointestinal Diseases: A Mendel Randomization Study

Gao

Yang

et al. 2023

Preprint

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Previous observational studies have reported a relationship between negative emotions and upper gastrointestinal disease. However, whether this relationship is causal remains unclear. We aimed to evaluate the causal relationship between negative emotions and upper gastrointestinal diseases using two-sample Mendelian randomization (MR). Three sets of genetic instruments from the database were obtained for analysis, including 12 anxiety-related single nucleotide polymorphisms (SNPs), 46 depression-related SNPs, and 58 nervous-related SNPs. SNPs were filtered using the Phenoscanner website, and the inverse variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum, and outlier test were used for analysis. In inverse variance weighted analysis, anxiety and depression had an effect on gastroduodenal ulcer (p = 2.849 × 10-3, β = 4.908, 95% CI = 1.684–8.132; and p = 6.457 × 10-4, β = 1.767, 95% CI = 0.752–2.782, respectively). Additionally, depression had an effect on diseases of the esophagus, stomach, and duodenum (p = 3.498 × 10-5，β = 0.926，95% CI = 0.487–1.364). Cochran’s Q-derived p-values were 0.457, 0.603, and 0.643, and MR-Egger intercept-derived p-values were 0.697, 0.294, and 0.362, respectively. Here, we show that anxiety and depression have a causal relationship with gastroduodenal ulcers, and depression has a causal relationship with diseases of the esophagus, stomach, and duodenum.

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“…Page 6/11 [17] . Moreover, FKBP5 polymorphism is associated with anxiety and depression in patients with advanced gastric cancer [18] .…”

Section: Discussionmentioning

confidence: 99%

Impact of Negative Emotions on Upper Gastrointestinal Diseases: A Mendel Randomization Study

Gao

Yang

et al. 2023

Preprint

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“…However, after adjustment of multivariate analysis, age may not have been related to negative emotions in our study. Other studies have pointed out that women are more likely to experience negative emotions ( 29 ). Some studies have improved a series of nursing measures to improve the psychological status of GC patients, so as to improve the prognosis of patients ( 4 , 5 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of negative emotions on patients with advanced gastric cancer receiving systemic chemotherapy: a prospective study

Tao¹,

Gong²,

Qian³

2023

J Gastrointest Oncol

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Background Most patients with advanced gastric cancer (GC) are treated with systemic chemotherapy and many factors have remarkable impacts on their prognosis. However, the importance of psychological status in the prognosis of advanced GC patients is still unclear. This prospective study was performed to analyze the impact of negative emotions on GC patients treated with systemic chemotherapy. Methods Advanced GC patients admitted to our hospital between January 2017 and March 2019 were prospectively enrolled. Demographic and clinical data were collected, as were any adverse events (AEs) related to systemic chemotherapy. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess negative emotions. The primary outcome was progression-free survival (PFS) and overall survival (OS), and the secondary outcome was the quality of life which was assessed by The European Organization for Research and Treatment of Quality of Life Questionnaire-Core 30. Cox proportional hazards models were used to analyze the effects of negative emotions on prognosis, and logistic regression models were used to analyze the risk factors related to negative emotions. Results A total of 178 advanced GC patients were enrolled in this study. A total of 83 patients were divided into a negative emotion group and 95 patients were divided into normal emotion group. 72 patients experienced AEs during treatment. Many more patients experienced AEs in the negative emotion group than in the normal emotion group (62.7% vs. 21.1%, P<0.001). Enrolled patients were followed up for at least 3 years. It was found both PFS and OS were much lower in the negative emotion group than in the normal emotion group (P=0.0186 and 0.0387, respectively). Participants in negative emotion group had lower health status and more severe symptoms. Negative emotions, lower body mass index (BMI), and IV tumor stage were identified as risk factors. In addition, higher BMI and marital status were identified as protective factors of negative emotions. Conclusions Negative emotions have a significant adverse effect on the prognosis of GC patients. The main risk factor of negative emotions is AEs during treatment. It is necessary to closely monitor the treatment process and improve the psychological status of patients.

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“…Concerning another retrospective clinical study conducted on 34 terminal gastric cancer patients admitted to a palliative care unit, evidence was presented supporting that patients with anxiety exhibited a higher probability of emergency admission, an elevated Numerical Rating Scale result, occurrence of cachexia and neuropsychiatric symptoms, a longer duration of treatment, increased albumin levels and increased glucose amounts [59]. Individuals with neuropsychiatric symptomatology also exhibited a higher probability of emergency admission, better performance status scale, occurrence of dyselectrolytemia and decreased albumin levels.…”

Section: Discussionmentioning

confidence: 99%

“…Individuals with neuropsychiatric symptomatology also exhibited a higher probability of emergency admission, better performance status scale, occurrence of dyselectrolytemia and decreased albumin levels. Notably, patients presenting those symptoms exhibited more than seven times a higher risk of death [59]. Another study, including 80 newly diagnosed gastric cancer patients and 80 healthy controls, assessed their anxiety and depression symptoms utilizing the HADS [60].…”

Section: Discussionmentioning

confidence: 99%

Association of Mediterranean Diet Adherence with Disease Progression Characteristics, Lifestyle Factors and Overall Survival in Gastric Cancer Patients

Pavlidou,

Papadopoulou,

Tolia

et al. 2023

Medical Sciences

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Background: The Mediterranean diet (MD) exerts a protective effect against cancer development and progression; however, the evaluation of its impact on gastric cancer still remains quite scarce. The present study aims to evaluate the association of MD adherence during the lifespan with disease progression characteristics, lifestyle factors and overall survival in gastric carcinoma patients. Methods: This is an observational, cross-sectional study conducted on 186 gastric cancer patients followed up for a median time interval of 57 months or until death due to cancer disease. Tumor histopathological characteristics were retrieved from patients’ medical records, while validated questionnaires assessing, immediately after the time of diagnosis, health-related quality of life, physical activity levels, sleep quality, depression, anxiety and MD adherence during the lifespan were used. Results: Higher MD adherence during the lifespan was significantly associated with younger patients (p = 0.0106), regular smoking (p < 0.0001), abnormal BMI status (p < 0.0001), intestinal-type gastric carcinoma (p = 0.0111), high tumor histopathological grade (p < 0.0001) and earlier disease stage (p < 0.0001). Moreover, patients with elevated MD adherence during their lifespan showed significantly better health-related quality of life (p < 0.0001), higher physical activity levels (p < 0.0001), more adequate sleep quality (p < 0.0001) and lower prevalence of depression (p = 0.0003) and anxiety (p = 0.0006) compared to those with reduced MD adherence. In multiple regression analysis, elevated MD compliance during the lifespan was independently correlated with longer overall patient survival after adjustment for several confounders (Cox regression analysis, p = 0.0001). Conclusions: Higher MD adherence during the lifespan was associated with less advanced tumor histopathology characteristics and favorable mental and physical lifestyle factors. Moreover, higher MD adherence during the lifespan was also independently correlated with longer overall survival in gastric carcinoma patients. Thus, adopting a healthy dietary pattern like the MD during the lifespan may act as a preventive agent in combination with a healthy lifestyle against gastric cancer development and progression.

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Factors connected with anxiety and other neuropsychiatric symptoms in advanced gastric cancer

Cited by 10 publications

References 20 publications

Impact of Negative Emotions on Upper Gastrointestinal Diseases: A Mendel Randomization Study

Impact of Negative Emotions on Upper Gastrointestinal Diseases: A Mendel Randomization Study

Effect of negative emotions on patients with advanced gastric cancer receiving systemic chemotherapy: a prospective study

Association of Mediterranean Diet Adherence with Disease Progression Characteristics, Lifestyle Factors and Overall Survival in Gastric Cancer Patients

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