Factors connected with the female sex seem to play an important role in differentiated thyroid cancer

Przybylik-Mazurek, Elwira; Hubalewska‐Dydejczyk, Alicja; Fedorowicz, Anna; Pach, Dorota

doi:10.3109/09513590.2011.563909

Cited by 18 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All 9 included studies provided sufficient information for the association between ever vs. never breastfeeding and thyroid cancer risk [10–13, 15–19]. The pooled analysis revealed a significant inverse association (RR=0.91, 95% CI 0.83–0.99), with little heterogeneity (I 2 =10.1%) (Table 3; Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Overall, 9 reports were included in the current meta-analysis [10–13, 15–19]. The detailed characteristics of these studies were demonstrated in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Besides, the highest category vs. the lowest category of duration of breastfeeding was suggested to be significantly associated with thyroid cancer risk in several cohort studies and case-control studies [10, 11]. On the other hand, some other epidemiological studies did not suggest a clear relationship between breastfeeding and thyroid cancer risk [12–19]. Considering that for each individual study the detected effect size may be limited by the relevant sample size, a summary of available evidence will be needed to clarify whether breastfeeding is significantly associated with thyroid cancer risk.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies

Zhu

et al. 2016

Clinical Nutrition

View full text Add to dashboard Cite

Background & Aims The association between breastfeeding and thyroid cancer risk is not consistent from epidemiological studies. To better clarify the association including assessing a potential dose-response relationship, we conducted a comprehensive meta-analysis. Methods We searched PubMed (MEDLINE) up to November 2015 for prospective studies or case-control studies that evaluated the association between breastfeeding and risk of thyroid cancer. Effect estimates were pooled using a fixed-effects model. Results Nine reports (2 prospective studies, 6 case-control studies and 1 pooled analysis of 14 case-control studies) involving 2423 cases and 350081 non-cases were identified. After pooling relevant studies, there was a significant inverse association between ever breastfeeding and risk of thyroid cancer (RR=0.91, 95% CI 0.83–0.99), with minor heterogeneity (I2=10.1%). The dose-response analysis revealed a significant linear relationship between the duration of breastfeeding and risk of thyroid cancer. The summary RR for an increment of 1 month of breastfeeding with risk of thyroid cancer was 0.983 (95% CI 0.98–0.99). When focusing on cohort studies, a more prominent linear dose-response relationship was detected, with the combined RR for every increment of 1 month of breastfeeding to be 0.965 (95% CI 0.96–0.97). Conclusions This meta-analysis suggests that breastfeeding is potentially inversely associated with thyroid cancer risk. Also longer duration of breastfeeding may further decreases thyroid cancer risk. If validated in large-scale prospective studies, our findings may have implications for impacting women’s decision in breastfeeding.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Overall, 9 reports were included in the current meta-analysis [10–13, 15–19]. The detailed characteristics of these studies were demonstrated in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies

Zhu

et al. 2016

Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…The detailed steps of the literature search were shown in Figure . After excluding 34 studies during the assessment of whole contents of 50 potential articles due to various reasons (the list of the 34 studies is available upon request), a total of 23 reports met the inclusion criteria and were included in this study . Since one study reported the risk estimates separately according to the age category (<45 years old or ≥45 years old) and the combined effect size was unable to determine based on available data, we treated the two estimates as from two separate studies and incorporated both in the pooled analysis.…”

Section: Resultsmentioning

confidence: 99%

Parity and thyroid cancer risk: a meta‐analysis of epidemiological studies

Zhu

et al. 2015

Cancer Medicine

View full text Add to dashboard Cite

Although observational studies have assessed the relationship between parity and thyroid cancer risk, the findings are inconsistent. To quantitatively assess the association, we conducted a systematic review and meta‐analysis. PubMed and Embase were searched up to January 2015. Prospective or case–control studies that evaluated the association between parity and thyroid cancer risk were included. We used the fixed‐effects model to pool risk estimates. After literature search, 10 prospective studies, 12 case‐control studies and 1 pooled analysis of 14 case‐control studies including 8860 patients were identified. The studies had fair methodological quality. Pooled analysis suggested that there was a significant association between parity and risk of thyroid cancer (RR for parous versus nulliparous: 1.09, 95% CI 1.03‐1.15; I2=33.4%). The positive association persisted in almost all strata of subgroup analyses based on study design, location, study quality, type of controls, and confounder adjustment, although in some strata statistical significance was not detected. By evaluating the number of parity, we identified that both parity number of 2 versus nulliparous and parity number of 3 versus nulliparous demonstrated significant positive associations (RR=1.11, 95% CI 1.01‐1.22; I2=31.1% and RR=1.16, 95% CI 1.01‐1.33; I2=19.6% respectively). The dose‐response analysis suggested neither a non‐linear nor linear relationship between the number of parity and thyroid cancer risk. In conclusion, this meta‐analysis suggests a potential association between parity and risk of thyroid cancer in females. However, the lack of detection of a dose‐response relationship suggests that further studies are needed to better understand the relationship.

show abstract

“…Hormonal exposure is a risk factor for thyroid cancer in women of <35 years of age [12]. The peak in thyroid cancer incidence seen in women during their reproductive years identifies hormonal changes related to irregular menstrual cycle [13], abortion [14], oral contraceptives [15], hormone replacement therapy [16] and fertility drugs [17] as relevant etiological factors.…”

Section: Introductionmentioning

confidence: 99%

Androgen receptor expression in human thyroid cancer tissues: A potential mechanism underlying the gender bias in the incidence of thyroid cancers

Stanley

Aruldhas

Chandrasekaran

et al. 2012

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

Factors connected with the female sex seem to play an important role in differentiated thyroid cancer

Abstract: The results of these studies imply that estrogens may at least modify the proliferation of thyroid cancer cells. The sex hormones probably intensify the actions of other carcinogens as well.

Cited by 18 publications

References 22 publications

Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies

Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies

Parity and thyroid cancer risk: a meta‐analysis of epidemiological studies

Androgen receptor expression in human thyroid cancer tissues: A potential mechanism underlying the gender bias in the incidence of thyroid cancers

Contact Info

Product

Resources

About