Factors contributing to infectious diarrhea-associated pancreatic enzyme alterations

Reimund, Jean‐Marie; Muller, Christian D.; Finck, G.; Escalin, G.; Duclos, Bernard; Baumann, René

doi:10.1016/s0399-8320(05)80757-2

Cited by 8 publications

(2 citation statements)

References 63 publications

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“…Most patients had alternative possible explanations for the pancreatitis, including concomitant medications or relevant medical history. Thus, it is unclear whether the combination of oxaliplatin and irinotecan on this schedule caused pancreatitis directly or whether elevated serum amylase and lipase were the result of severe diarrhea, as described in patients with infectious diarrhea 57…”

Section: Discussionmentioning

confidence: 99%

A functional polymorphism in the catechol‐O‐methyltransferase gene is associated with osteoarthritis‐related pain

Meurs¹,

Uitterlinden²,

Stolk³

et al. 2009

Arthritis & Rheumatism

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The separability between overall and internal motions is evaluated over multiple folding trajectories of the villin headpiece subdomain. The analysis, which relies on the Prompers‐Brüschweiler separability index, offers a potentially useful perspective on protein folding. The protein is considered folded in this study, not when it reaches some static target, but rather when it tumbles as a dynamically constrained object. The analysis also demonstrates how the separability index, when applied to protein folding simulations, can facilitate the analysis of NMR relaxation data. Proteins 2012;. © 2012 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

A functional polymorphism in the catechol‐O‐methyltransferase gene is associated with osteoarthritis‐related pain

Meurs¹,

Uitterlinden²,

Stolk³

et al. 2009

Arthritis & Rheumatism

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“…In human medicine, various infectious agents that cause enteritis have been associated with AP based on increased serum amylase and/or lipase activities . In some instances, morphologic abnormalities of the pancreas have been demonstrated by abdominal ultrasonography or computed tomography …”

Section: Introductionmentioning

confidence: 99%

Prevalence of increased canine pancreas‐specific lipase concentrations in young dogs with parvovirus enteritis

Kalli

Adαmama-Moraitou

Patsika

et al. 2017

Veterinary Clinical Pathol

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Phase 1 study of oxaliplatin and irinotecan in pediatric patients with refractory solid tumors

McGregor

Spunt

Furman

et al. 2009

Cancer

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BACKGROUND:For this report, the authors estimated the maximum tolerated dose (MTD) and investigated the toxicities of oxaliplatin combined with irinotecan in children with refractory solid tumors.METHODS:Oxaliplatin was administered on Days 1 and 8 in combination with irinotecan on Days 1 through 5 and Days 8 through 12 of a 21‐day cycle. An oral cephalosporin was administered daily to ameliorate irinotecan‐associated diarrhea. Pharmacokinetic studies of oxaliplatin and uridine diphosphate glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) genotyping were performed.RESULTS:Thirteen patients were enrolled. Dose‐limiting diarrhea (n = 3), serum lipase elevation (n = 3), serum amylase elevation (n = 2), colitis, abdominal pain, and headache (n = 1 each) occurred at the first dose level (oxaliplatin at a dose of 60 mg/m2; irinotecan at a dose of 20 mg/m2). Only 1 of 7 patients who received reduced doses of both agents (40 mg/m2/dose oxaliplatin; 15 mg/m2/dose irinotecan) experienced a dose‐limiting toxicity (DLT): diarrhea. When the oxaliplatin dose was re‐escalated (60 mg/m2) with irinotecan at a dose of 15 mg/m2, 2 of 3 patients had a DLT (1 episode of diarrhea, 1 episode of hypokalemia). Myelosuppression was minimal. One patient had a complete response, and another patient had stable disease for 6 cycles of therapy. The median oxaliplatin area under the concentration versus time curve (AUC0→∞) was 5.9 μg · hour/mL (range, 1.8‐7.6 μg · hour/mL). The frequency of the 6/6, 6/7, and 7/7 UGT1A1 promoter genotypes was 5 of 10, 4 of 10, and 1 of 10, respectively.CONCLUSIONS:The oxaliplatin MTD was 40 mg/m2 per dose on Days 1 and 8 in combination with irinotecan 15 mg/m2 per dose on Days 1‐5 and Days 8‐12. There was some evidence of antitumor activity; however, severe toxicity, both expected (diarrhea) and unexpected (elevation in pancreatic enzymes), was observed. Cancer 2009. © 2009 American Cancer Society.

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Factors contributing to infectious diarrhea-associated pancreatic enzyme alterations

Cited by 8 publications

References 63 publications

A functional polymorphism in the catechol‐O‐methyltransferase gene is associated with osteoarthritis‐related pain

A functional polymorphism in the catechol‐O‐methyltransferase gene is associated with osteoarthritis‐related pain

Prevalence of increased canine pancreas‐specific lipase concentrations in young dogs with parvovirus enteritis

Phase 1 study of oxaliplatin and irinotecan in pediatric patients with refractory solid tumors

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