Factors Contributing to the Low Survival Among Women With a Diagnosis of Invasive Cervical Cancer in Ghana

Nartey, Yvonne; Hill, Philip C.; Amo‐Antwi, Kwabena; Nyarko, Kofi Mensah; Yarney, Joel; Cox, Brian

doi:10.1097/igc.0000000000001088

Cited by 18 publications

(23 citation statements)

References 26 publications

(14 reference statements)

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“…The chances of a cervical cancer patient to survive one year after diagnosis is 62%; three years after diagnosis, 29%; and 5 years after diagnosis, 30%. 10 Studies showed that several factors significantly correlate with cervical cancer. These are early sexual intercourse (engaged before 20 years), parity (more than three live births), and the use of hormonal contraceptives (exceeding five years).…”

Section: Introductionmentioning

confidence: 99%

Duration of Hormonal Contraception and Risk of Cervical Cancer

Kusmiyati

Prasistyami

Wahyuningsih

et al. 2019

Kesmas: National Public Health Journal

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The use of long hormonal contraceptives can disrupt the balance of estrogen in the body, resulting in abnormal cell changes. This study aimed to determine a correlation between the duration of hormonal contraception and risk of cervical cancer. This study used a case-control design. The population were patients who had examined at a cancer installation and obstetrics-gynecology polyclinic Dr. Sardjito Hospital in 2018. Case samples were 95 women have cervical cancer diagnosis and control were 95 women with a negative pap smear. Sampling with random sampling. Dependent variable cervical cancer and independent variable the duration of hormonal contraception are obtained from medical records. Cervical cancer is assessed by doctor’s diagnosis. Data analysis used logistic regression. Results showed that 44.7% of samples used long-term hormonal contraception (over 5 years). Length of use of hormonal contraception had a significant correlation with the incidence of cervical cancer (p-value < 0.01). Hormonal contraceptive use more than 5 years have a risk 4.2 times (95% CI 1.01-5.69) of cervical cancer than using less than 5 years after being controlled with the first marriage age and parity

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Section: Introductionmentioning

confidence: 99%

Duration of Hormonal Contraception and Risk of Cervical Cancer

Kusmiyati

Prasistyami

Wahyuningsih

et al. 2019

Kesmas: National Public Health Journal

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“…2,3 At three years from diagnosis, overall disease-specific survival was 39%. 5 Stage at presentation (Hazard ratio (HR) for stage IV compared with stage I was 7.8; 95% CI: 4.1-14.8) and histological type (HR for other histological types compared with squamous cell carcinoma was 1.4; 95% CI: 0.4-5.9, not statistically significant) were strong predictors of cervical cancer survival. Some forms of treatment were also associated with better survival than others.…”

Section: Introductionmentioning

confidence: 99%

“…2,3,5 Structured telephone interviews were also conducted for patients and relatives to gather further information on the outcome of the disease. The second study assessed the risk factors for cervical cancer in Ghana, using a hospital-based case-control study.…”

Section: Introductionmentioning

confidence: 99%

Recommendations for cervical cancer prevention and control in Ghana: public education and human papillomavirus vaccination

Nartey¹,

Hill²,

Amo‐Antwi³

et al. 2018

Ghana Medical Journal

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SUMMARYGlobally, cervical cancer is a major public health issue causing increasing morbidity and mortality especially in lowand middle-income countries where preventive and control measures are lacking. In Ghana, it is the most common cancer among women. Approaches to reduce the incidence and mortality of the disease in Ghana have had little success due to lack of accurate data on the disease among other factors, to inform policies on prevention, early detection, diagnosis and treatment. Additionally, the lack of clear commitment, policy direction and resources has hindered the scale-up of some of the initiatives implemented to curb the cervical cancer situation in Ghana. In this paper, we make recommendations on cervical cancer education and human papillomavirus vaccination. A collaborative approach is needed involving both private and government organizations, health professionals and the general public. Public education on cervical cancer and HPV vaccination needs to be delivered through a mixture of systems including both healthcare facilities and outreach programs, involving teachers, youth groups, community members and professional bodies. The vaccination of adolescents aged 10-14 years using the nonavalent HPV vaccine will be important in reducing the incidence and mortality of cervical cancer in Ghana. The integration of public education on cervical cancer prevention, HPV vaccination and screening programs into both medical and public health services is critical in achieving high coverage of these programs. Funding: None

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“…In LMICs lacking well-resourced treatment centers with geographic and financial barriers, treatment outcomes have been less than desired. 3 …”

Section: Introductionmentioning

confidence: 99%

Comparison of Definitive Cervical Cancer Management With Chemotherapy and Radiation Between Two Centers With Variable Resources and Opportunities for Improved Treatment

Asamoah

Yarney

Scott

et al. 2020

JCO Global Oncology

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PURPOSE Cervical cancer remains a major health challenge in low- to middle-income countries. We present the experiences of two centers practicing in variable resource environments to determine predictors of improved radiochemotherapy treatment. METHODS AND MATERIALS This comparative review describes cervical cancer presentation and treatment with concurrent chemoradiotherapy with high-dose-rate brachytherapy between 2014 and 2017 at the National Radiotherapy Oncology and Nuclear Medicine Center (NRONMC) in Korle-Bu Teaching Hospital, Accra, Ghana, and Moffitt Cancer Center (MCC), Tampa, FL. RESULTS Median follow-up for this study was 16.9 months. NRONMC patients presented with predominantly stage III disease (42% v 16%; P = .002). MCC patients received para-aortic node irradiation (16%) and interstitial brachytherapy implants (19%). Median treatment duration was longer for NRONMC patients compared with MCC patients (59 v 52 days; P < .0001), and treatment duration ≥ 55 days predicted worse survival on multivariable analysis (MVA; P = .02). Stage ≥ III disease predicted poorer local control on MVA. There was a difference in local control among patients with stage III disease (58% v 91%; P = .03) but not in survival between MCC and NRONMC. No significant difference in local control was observed for stage IB, IIA, and IIB disease. CONCLUSION Although there were significant differences in disease presentation between the two centers, treatment outcomes were similar for patients with early-stage disease. Longer treatment duration and stage ≥ III disease predicted poor outcomes.

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Factors Contributing to the Low Survival Among Women With a Diagnosis of Invasive Cervical Cancer in Ghana

Cited by 18 publications

References 26 publications

Duration of Hormonal Contraception and Risk of Cervical Cancer

Duration of Hormonal Contraception and Risk of Cervical Cancer

Recommendations for cervical cancer prevention and control in Ghana: public education and human papillomavirus vaccination

Comparison of Definitive Cervical Cancer Management With Chemotherapy and Radiation Between Two Centers With Variable Resources and Opportunities for Improved Treatment

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