Factors correlated with targeted prevention for prediabetes classified by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c: A population-based longitudinal study

Abstract

BackgroundThere is still controversy surrounding the precise characterization of prediabetic population. We aim to identify and examine factors of demographic, behavioral, clinical, and biochemical characteristics, and obesity indicators (anthropometric characteristics and anthropometric prediction equation) for prediabetes according to different definition criteria of the American Diabetes Association (ADA) in the Chinese population.MethodsA longitudinal study consisted of baseline survey and two follow-ups was conducted, and a pooled data were analyzed. Prediabetes was defined as either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or elevated glycosylated hemoglobin (HbA1c) according to the ADA criteria. Robust generalized estimating equation models were used.ResultsA total of 5,713 (58.42%) observations were prediabetes (IGT, 38.07%; IGT, 26.51%; elevated HbA1c, 23.45%); 9.66% prediabetes fulfilled all the three ADA criteria. Among demographic characteristics, higher age was more evident in elevated HbA1c [adjusted OR (aOR)=2.85]. Female individuals were less likely to have IFG (aOR=0.70) and more likely to suffer from IGT than male individuals (aOR=1.41). Several inconsistency correlations of biochemical characteristics and obesity indicators were detected by prediabetes criteria. Body adiposity estimator exhibited strong association with prediabetes (D10: aOR=4.05). For IFG and elevated HbA1c, the odds of predicted lean body mass exceed other indicators (D10: aOR=3.34; aOR=3.64). For IGT, predicted percent fat presented the highest odds (D10: aOR=6.58).ConclusionSome correlated factors of prediabetes under different criteria differed, and obesity indicators were easily measured for target identification. Our findings could be used for targeted intervention to optimize preventions to mitigate the obviously increased prevalence of diabetes.

Global research trends in prediabetes over the past decade: Bibliometric and visualized analysis

“…Zhu found differences in prediabetes by different criteria in a longitudinal study and stated that targeted prevention should be categorized by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c. [40] Patients with prediabetes are at high risk of developing diabetes and have high prevalence of dyslipidemia, high levels of atherogenic lipids, and increased risk of atherosclerotic cardiovascular disease. For patients with elevated IGT and/or 7-hour plasma glucose, the same intensive treatment of dyslipidemia as recommended for diabetes should be considered.…”

Diagnostic Accuracy of Anthropometric Markers of Obesity for Prediabetes: A Systematic Review and Meta-Analysis

“…In many studies, it has been found that anthropometric measures of obesity, such as waist circumference (WC) [11,12] or waist-to-height ratio (WHtR) [13,14] and body mass index (BMI) [9,10] play an important role as risk factors in the manifestation of prediabetes. These measures, derived from simple and accessible indicators, are crucial for identifying patients at risk; this allows for the implementation of strategies to preventively intervene to significantly halt the onset of diabetes.…”

Momordica balsamina improves glucose handling in a diet-induced prediabetic rat model

“…Prediabetes is a prominent risk factor for the onset of type 2 diabetes [ 1 ]. Prediabetes is a metabolic complication that is characterized by impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and elevated glycated hemoglobin (HbA1c) [ 2 ]. Literatures have shown that impaired glucose homeostasis is a result of resistance of insulin receptor substrate 1 (IRS-1) to insulin in targeted tissues [ 3 ].…”