Factors Determining the Post-Operative Hypo-Albuminaemia in Cancer Patients-Stepwise Regression Analysis

Abstract

Postoperative albuminaemia is positively correlated with pre-operative albuminaemia and male gender and negatively correlated with the duration of surgery, pre-operative proteinaemia and postoperative Ig administration.

Risk and predictive factors of hypoalbuminemia in cancer patients following extensive abdominal surgery despite total parenteral nutritional support

“…Moreover, postoperative hypoalbuminemia was deterred by elevated preoperative SA levels. These observations partly concord with previous reports in cancer patients following thoracic or abdominal surgery (Duda et al 2003).…”

“…Moreover, the potential mediating effects of cancer cachexia and/or the presence of distal hepatic metastases upon postoperative SA levels was not assessed due to the study design applied. Finally, the postoperative administration of TPN, including FFP and HAS, in patients following EAS was similar to previous reports (Fiorica et al 1991;Duda et al 2003) in order to enhance vital functions and clinical outcome (Vincent et al 2004;Dubois et al 2006). Deprivation of such adjuvant support for study purposes would have notably compromised bioethical standards.…”

“…The occurrence of postoperative hypoalbuminemia among the study population was greatest on POD 2. Similar reports have indicated that the nadir of postoperative hypoalbuminemia occurs on POD 3 (Duda et al 2003). The observed discrepancy may be attributed to the beneficial effects of daily postoperative TPN administration in EAS patients of the present study.…”

“…Furthermore, the extent of surgical intervention often required for radical tumour resection encompasses substantial trauma (Duda et al 2003;Hildebrandt et al 2003;Ló pez Hellín et al 2008), the magnitude of which is proximally correlated with the degree of total serum protein depletion (Tashiro et al 1996;Gibbs et al 1999;Pessaux et al 2003). In addition, intra-operative blood volume loss may compound SA level reduction (Sun et al 2009).…”

“…To deter the development of postoperative hypoalbuminemia and consequent adverse clinical outcomes (Longo et al 2000), total parenteral nutritional support (TPN), including fresh frozen plasma (FFP) and human albumin solution (HAS), is often required to replete the side effects of operative blood volume losses and sustain optimal serum protein levels (Duda et al 2003;Kudsk et al 2003;Ryan et al 2007). However, to date, prospective studies aimed at assessing the risk and predictive factors of postoperative hypoalbuminemia in cancer patients following EAS, despite TPN support, are limited (Orr et al 1983;Fiorica et al 1991;Kudsk et al 2003).…”