Factors Determining the Sex Differences in Pituitary and Serum FSH-Contents After Gonadectomy

Gans, Eugene H.; Jongh, S. E. de

doi:10.1530/acta.0.0430323

Cited by 12 publications

(7 citation statements)

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“…The increase in pituitary FSH after bilateral ovariectomy in the hamster parallels the findings in other species (Cozens & Nelson, 1961 ;Gans & de Jongh, 1963) except that the increase in the hamster occurs more rapidly, within 4 days. Until day 4, the FSH pattern of the unilaterally and bilaterally ovariectomized hamsters is similar except that the increase is somewhat greater in the latter group.…”

Section: Discussionsupporting

confidence: 81%

Studies on Interactions Between the Ovary and Pituitary Follicle-Stimulating Hormone in the Golden Hamster

Grady¹,

Greenwald²

1968

Journal of Endocrinology

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During the first 3 days of the oestrous cycle of the hamster, pituitary follicle-stimulating hormone (FSH) is relatively constant. However, a decrease in concentration occurred between days 3 and 4. The drop in pituitary FSH\p=m-\whichwas not statistically significant\p=m-\coincided with a period of follicular atresia.After unilateral ovariectomy on day 1, the remaining ovary ovulates twice the normal number of ova. After semi-spaying, pituitary FSH increased over control values on days 2 and 3 and then decreased sharply by day 4. This suggests that the release of FSH between days 3 and 4 prevents atresia and is therefore responsible for compensatory ovulation. Bilateral ovariectomy on day 1 resulted on days 2 and 3 in pituitary FSH concentrations comparable to those in the unilaterally ovariectomized group. However, pituitary FSH increased markedly on day 4 in the bilaterally ovariectomized hamster.Superovulation of approximately 70 eggs occurs after the administration of 60 i.u. pregnant mare serum (PMS) on day 1. A drastic decrease in pituitary FSH took place on days 3 and 4, indicating reduced synthesis of the hormone. The decrease in pituitary FSH between days 2 and 3 is due to ovarian stimulation by PMS inasmuch as the decrease did not occur in animals bilaterally ovariectomized and injected with PMS. The existence of a 'short feedback loop' for FSH is demonstrated by the finding that the increase in pituitary FSH between days 3 and 4 was much greater in bilaterally ovariectomized females than in castrated animals injected with PMS.

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Section: Discussionsupporting

confidence: 81%

Studies on Interactions Between the Ovary and Pituitary Follicle-Stimulating Hormone in the Golden Hamster

Grady¹,

Greenwald²

1968

Journal of Endocrinology

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“…Johnson (1967) also showed a significantly greater amount of circulating fsh in intact males when measured by the method of parabiosis. In gonadectomized animals, there is an increase in plasma fsh content and higher levels were found in castrated males than in spayed females (Gans, 1959;Gans & de Jongh, 1963). Parlow (1964), on the contrary, did not observe any sex difference using the Steelman and Poley method.…”

Section: Discussionmentioning

confidence: 74%

“…No difference was reported in the plasma fsh content of intact male and female rats, as measured by the increase in testicular weight in hypophysectomized hemicastrated animals (Gans & de Jongh, 1963). However, using the augmentation test of testis weight in hypophysectomized immature rats, the serum of intact male rats was found to be more active than that of females (Gans & van Rees, 1966).…”

Section: Discussionmentioning

confidence: 85%

“…Johnson & Witschi (1963a,b) observed, by the parabiotic tech¬ nique, that the removal of the ovaries from androgenized female rats resulted in an increase of circulating fsh but the levels were probably subnormal. Gans & de Jongh (1963), on the other hand, reported that the higher levels of fsh in castrated males, as compared to spayed females, were maintained even if gonadectomy was carried out on the 1st day of life.…”

Section: Discussionmentioning

confidence: 98%

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Positive Feed-Back Effect of Progesterone on the Release of FSH and the Influence of Sex in Rats

Taleisnik¹,

Caligaris²,

Astrada³

1970

Reproduction

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Plasma fsh activity (as measured by the ovarian augmentation test in mice) was increased in gonadectomized male and female rats. A single injection of 20 \g=m\g oestradiol benzoate (OB) or one or two doses of 2\m=.\5 mg testosterone propionate (TP) 3 days later reduced the raised values significantly. Progesterone injected into spayed rats, primed 3 days before with OB or TP, induced, a few hours later, a significant increase in plasma fsh. By contrast, in male rats progesterone failed to exert a positive feed-back effect on the release of fsh. This sex difference was suppressed by the injection of testosterone into female rats on the 4th day of life. In male rats castrated soon after birth, progesterone showed a tendency to increase the activity of fsh in plasma in animals primed either with OB or TP, but the difference of the values as compared to the controls did not reach the level of significance. It is concluded that the sex difference of the positive feed-back effect of progesterone on the release of fsh could be due to a post-natal differentiation of a neural mechanism.

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“…Although many reports are available on the concentrations of pituitary gonado¬ trophins in ovariectomized rats (Parlow, 1959, 19646;Gans & de Jongh, 1963), there are few reports on mice. Hypersécrétion of gonadotrophins after ovariectomy in the mouse has been reported in parabiotic animals by Miyake (1961) Parlow (1964 a).…”

Section: Discussionmentioning

confidence: 99%

Follicle-Stimulating Hormone Content of the Pituitary Glands of Intact and Ovariectomized Mice of Different Strains

Karande¹,

Sheth²,

Ranadive³

1970

Journal of Endocrinology

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The follicle-stimulating hormone (FSH) content of the pituitaries of intact and ovariectomized mice of the strains C3H/Jax and ICRC, which differ in their adrenocortical responses to ovariectomy was measured at different ages. It was always higher in intact ICRC than that in intact C3H mice, particularly in younger age groups. Ovariectomy caused a fivefold increase in the FSH content in C3H mice after 1 month which was maintained up to 6 months. Thereafter there was a gradual decrease up to 12 months. The increase in pituitary FSH content in ICRC mice after ovariectomy was much less and occurred at a later age. These results agree with cytological observations on the pituitaries of these two strains.

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Factors Determining the Sex Differences in Pituitary and Serum FSH-Contents After Gonadectomy

Cited by 12 publications

References 0 publications

Studies on Interactions Between the Ovary and Pituitary Follicle-Stimulating Hormone in the Golden Hamster

Studies on Interactions Between the Ovary and Pituitary Follicle-Stimulating Hormone in the Golden Hamster

Positive Feed-Back Effect of Progesterone on the Release of FSH and the Influence of Sex in Rats

Follicle-Stimulating Hormone Content of the Pituitary Glands of Intact and Ovariectomized Mice of Different Strains

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