In this paper, we present a comparative Gap Frame analysis, assessing the sustainability and development challenges of Nigeria and Ghana across waste management, social integration, peace and cooperation, and education. The Gap Frame, aligned with the Sustainable Development Goals (SDGs), provides a detailed examination of each country's performance, highlighting both unique and shared obstacles. The analysis reveals Nigeria's pronounced challenges across all dimensions. In waste management, both countries face severe deficiencies, necessitating systemic improvements. Social integration issues are particularly acute in Nigeria, with significant concerns over tolerance and minority rights. Peace and cooperation analyses underscore Nigeria's struggles with legal rights and a high terrorism threat, while Ghana displays relatively better conditions. Education is a critical concern, with Nigeria's low enrolment rates and quality of education demanding urgent reform, and Ghana also facing substantial challenges despite better indicators. Targeted recommendations include enhancing waste treatment, enforcing antidiscrimination laws, strengthening legal systems, and investing in education. These strategies are vital for overcoming challenges and progressing towards sustainable development. The paper advocates for a multifaceted approach involving policy reform, community engagement, and international cooperation. This study provides insights into the broader African and global context for sustainability and development, emphasizing the urgency for collaborative action. It underscores the potential for significant strides towards a sustainable and prosperous future with sustained commitment and strategic efforts. The findings aim to inspire continued efforts towards the SDGs and enhancing citizen well-being in Nigeria and Ghana.